Chronical cervical infections and dysplasia (CIN I, CIN II): Vaginal vitamin D (high dose) treatment

Abstract

In a small praxis/ambulance study we evaluated data of 200 women with chronical recurrent cervical infections and with a cervix dysplasia (CIN 1, CIN 2). who got after the primary therapy a treatment with vitamin D vaginal suppositories (12.500 IU, 3 nights a week, for 6 weeks). We found that - when compared with the lactobacillus vaginal suppositories - the high dose vitamin D vaginal treatment might be more effective. Vitamin D showed very good anti-inflammatory effects. In the survey after six weeks therapy 79% of the women had “less vaginal problems,” “less discharge” and “less problems with the sexual intercourse.” Objectively after six weeks therapy only 7% of the patients still had bacterial and/or fungal vaginal infections that required a treatment. We found that vitamin D is reabsorbed by the vaginal mucosa, but the reabsorption may be individually very different. In the CIN 1 group we found six weeks after treatment good antidysplastic effects, in the CIN 2 group we often found no or only temporary antidysplastic effects. So this vaginal vitamin D treatment method might be an option for the therapy and prevention of chronical cervical infections and maybe of a cervic dysplasia CIN 1 (good antiinflammatory effects, antidysplastic effects). This small study is not representative. We need much bigger studies with much more dates and with a longer follow up. Caution: At the moment we do not know, if the vaginal vitamin D treatment with 12500 IE is possible in pregnancy. We have no experience. Therefore we recommend an effective contraception during the application.

Lack of association between serum 25-hydroxyvitamin D levels and cervical human papillomavirus infection in systemic lupus erythematosus

“…Thus, at the moment vaginal vitamin D treatment method cannot be seen as an alternative to the HPV vaccination. 43 We found no significant difference in vitamin D levels in SLE women with and without cervical squamous intraepithelial lesions. Most studies that have found a relationship between cervical HPV infection and vitamin D deficiency have measured vitamin D intake.…”

“…Thus, at the moment vaginal vitamin D treatment method cannot be seen as an alternative to the HPV vaccination. 43…”

The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development

“…Regarding nutrients, different antioxidants may have differing abilities to intervene in the natural history of cervical diseases associated with HPV infection. The intake of vitamins A and D may inhibit early events of cervical cancer development (from HPV infection to CIN 1 development) [ 14 , 16 , 17 , 18 , 26 , 27 , 28 , 29 ]. In addition, the intake of carotenoids may also inhibit early events (HPV infection) [ 30 , 31 , 32 , 33 , 34 ].…”

“…After 6 months of vitamin D administration, more women in the vitamin D group had regressed CIN 1 in comparison to the non-vitamin D group (84.6% vs. 53.8%, p = 0.01), and the intake of vitamin D led to a significant reduction in serum insulin levels in comparison to the non-vitamin D group (−5.3 ± 7.3 vs. +2.4 ± 5.9 μIU/mL, p < 0.001). Schlte-Uebbing et al also reported that treatment with vitamin D vaginal suppositories (12,500 IU, three nights a week, for 6 weeks) resulted in antidysplastic effects in the CIN 1 group, but that it did not affect the CIN 2 group [ 27 ]. Ozgu et al showed that the 25-hydroxy vitamin D level in 22 HPV-positive patients was significantly lower than that in 62 HPV-negative patients (8.2891 vs. 11.4262 IU/mL, respectively) [ 28 ].…”

The Effects of the Dietary and Nutrient Intake on Gynecologic Cancers

“…Thus, they hypothesized that the anti-inflammatory and anti-oxidative effects of vitamin D actions may be useful for reducing the risk of CIN 1. The report of Schulte-Uebbing et al which showed that treatment with vitamin D vaginal suppositories (12,500 IU, three nights a week, for 6 weeks) resulted in antidysplastic effects in patients with CIN 1, but not those with CIN 2, supports this hypothesis [27].…”