Chronic venous insufficiency and venous leg ulceration

Valencia, Isabel C.; Falabella, Anna; Kirsner, Robert S.; Eaglstein, William H.

doi:10.1067/mjd.2001.111633

Cited by 432 publications

(423 citation statements)

References 145 publications

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“…Venous leg ulcers are an important medical issue due to their high incidence in the elderly and the lack of a standard curative approach (1,2). Apart from surgical therapy, different medical treatments to effect ulcer wound repair and regeneration are currently being investigated (3,4).…”

Section: Introductionmentioning

confidence: 99%

Topical treatment of chronic venous ulcers with sucralfate: A placebo controlled randomized study

Tumino¹,

Masuelli²,

Bei³

et al. 2008

Int J Mol Med

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Abstract. Venous leg ulcers are an important medical issue due to their high incidence in the elderly and the lack of a standard curative approach. Apart from surgical therapy, different medical treatments to effect ulcer wound repair and regeneration are currently being investigated. Sucralfate is a cytoprotective agent employed to prevent or treat several gastrointestinal diseases such as gastroesophageal reflux, gastritis, peptic ulcer, stress ulcer and dyspepsia. In this study we evaluated the efficacy, safety and tolerability of topical sucralfate (SUC-LIS 95) on the healing of chronic venous leg ulcers in 50 patients by a double-blind, placebo-controlled, randomized study. Our results indicated that the daily application of SUC-LIS 95 to non-infected post-phlebitis/vascular ulcers, for a median period of 42.0 days, led to complete healing in 95.6% of patients, against only 10.9% of cases with a matched placebo. A significant improvement was obtained in the SUC-LIS 95-treated patient group with regard to local tissue inflammation as well as pain and burning, and consequently, in ulcer size and the evolution of granulation tissue. Our findings were corroborated for selected patients by the morphological analysis of biopsies obtained before and after treatment. Using ultrastructural analysis we demonstrated that the topical use of SUC-LIS 95 was able to affect neoangiogenesis, increase wound contraction, promote re-epithelialization of the wound area and diminish the inflammatory reaction. Overall, our results indicated that patients with chronic venous ulcers show improvement after the use of topical sucralfate.

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Section: Introductionmentioning

confidence: 99%

Topical treatment of chronic venous ulcers with sucralfate: A placebo controlled randomized study

Tumino¹,

Masuelli²,

Bei³

et al. 2008

Int J Mol Med

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show abstract

“…Severe complications include cellulitis, severe dermatitis, wound pain, osteomyelitis, and malignant change [8]. Although the overall prevalence is relatively low, the refractory nature of these ulcers increase the risk of morbidity and mortality, and have a significant impact on patient quality of life [5,7]. The financial burden of venous ulcers is estimated to be $2 billion per year in the United States [9].…”

Section: Introductionmentioning

confidence: 99%

“…The primary risk factors are older age, obesity, previous leg injuries, deep venous thrombosis, and phlebitis [6]. Venous ulcers usually recur and can persist from weeks to many years [7]. Severe complications include cellulitis, severe dermatitis, wound pain, osteomyelitis, and malignant change [8].…”

Section: Introductionmentioning

confidence: 99%

Improvement in Clinical Outcomes, Physical Function, and Bodily Pain Following a 12 Week Course of Intermittent Pneumatic Compression Therapy in Patients with Chronic Venous Ulcers: Results of an Observational Longitudinal Retrospective Study

Lullove¹,

Alvarez²

2014

Cureus

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“…2 Venous ulcers are the most common type and represent 80% of ulcers in lower limbs with an overall prevalence ranging between 0.06 and 3.6%. [3][4][5][6] The most common and important cause of ulcers in the lower limbs is chronic venous insufficiency, followed by arterial disease which represents 10 to 25% of all ulcers and may coexist with venous disease. [2][3][4] Most venous ulcers are treated with some type of compression (compressive bands/Unna boots); thus, if patients present any arterial insufficiency, this commonly used treatment will be of little benefit and may also delay the healing process of an ulcer and cause greater damage, such as more pronounced ischemia in the affected limb.…”

Section: Introductionmentioning

confidence: 99%

Avaliação da circulação arterial pela medida do índice tornozelo/braço em doentes de úlcera venosa crônica

Bergonse

Rivitti

2006

An. Bras. Dermatol.

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BACKGROUND -Chronic venous ulcers are extremely frequent and have a significant impact on quality of life and work productivity of individuals, in addition to high costs to public health. OBJECTIVES -Detection of arterial circulation alterations in chronic venous ulcer legs using a non-invasive method to discriminate patients not indicated to have compressive treatment. METHODS -Forty patients with chronic venous ulcers were investigated for the presence of peripheral arterial disease with measurement of the ankle/brachial index by Doppler ultrasound. RESULTS -The resting ankle/brachial pressure index was abnormal (lower than 1) in 9/22 (40.9%) patients with concomitant chronic venous ulcers and hypertension and only in one out of 13 (7.7%) patients with chronic venous ulcers and no hypertension. CONCLUSIONS -Patients with concomitant chronic venous ulcer and hypertension should be routinely evaluated with the ankle/brachial pressure index to detect a possible association with peripheral arterial disease. Keywords: Arterial occlusive diseases; Ultrasonography, doppler; Varicose ulcer Resumo: FUNDAMENTOS -As úlceras venosas dos membros inferiores são freqüentes e têm grande impacto na qualidade de vida e produtividade do indivíduo, além de alto custo para a saúde pública. OBJETIVOS -Detecção de alterações arteriais em pacientes de úlcera venosa crônica dos membros inferiores com emprego de método não invasivo, de modo a discriminar aqueles em que estaria contra-indicado o tratamento compressivo. MÉTODOS -Foram estudados

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Chronic venous insufficiency and venous leg ulceration

Cited by 432 publications

References 145 publications

Topical treatment of chronic venous ulcers with sucralfate: A placebo controlled randomized study

Topical treatment of chronic venous ulcers with sucralfate: A placebo controlled randomized study

Improvement in Clinical Outcomes, Physical Function, and Bodily Pain Following a 12 Week Course of Intermittent Pneumatic Compression Therapy in Patients with Chronic Venous Ulcers: Results of an Observational Longitudinal Retrospective Study

Avaliação da circulação arterial pela medida do índice tornozelo/braço em doentes de úlcera venosa crônica

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