Chronic Urticaria Associated With Coeliac Disease

Hautekeete, M. L.; Clerck, L. De; Stevens, W.J.

doi:10.1016/s0140-6736(87)91986-6

Cited by 27 publications

(19 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[15–17] Case reports are important for generating hypotheses but offer little evidence of a true association. Previous case-control studies[19, 23, 24] have been contradictory.…”

Section: Discussionmentioning

confidence: 99%

“…Over the past few years, a number of case reports have indicated a positive association between urticaria and CD,[15–18] but also with other autoimmune diseases[19]. Patients with CD also demonstrate an increased mucosal permeability and hypothetically an increased passage of antigens, and subsequently the formation of immune complex, may contribute to an excess risk of urticaria.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Does urticaria risk increase in patients with celiac disease? A large population-based cohort study

Ludvigsson¹,

Lindelöf²,

Rashtak³

et al. 2013

European Journal of Dermatology

View full text Add to dashboard Cite

Background Case reports and smaller case-control studies suggest an association between celiac disease (CD) and urticaria, but risk estimates have varied considerably across studies and as yet there are no studies on CD and the risk of future urticaria. Objective To examine the association between CD and urticaria. Methods We identified 28,900 patients with biopsy-verified CD (equal to Marsh stage 3) and compared them with 143,397 age- and sex-matched controls with regards to the risk of urticaria and chronic urticaria (duration ≥6 weeks). Hazard ratios (HRs) were estimated using a Cox regression model. Results During follow-up, 453 patients with CD and no previous diagnosis of urticaria developed urticaria (expected n=300) and 79 of these 453 had chronic urticaria (expected n=41). The corresponding HRs were 1.51 for any urticaria (95%CI=1.36–1.68) and 1.92 for chronic urticaria (95%CI=1.48–2.48). The absolute risk for urticaria in CD was 140/100,000 person-years (excess risk=47/100,000 person-years). Corresponding figures for chronic urticaria were 24/100,00 person-years and 12/100,000 person-years. Patients with CD were also at increased risk of having both urticaria (odds ratio, OR=1.31; 95%CI=1.12–1.52) and chronic urticaria (OR=1.54; 95%CI=1.08–2.18) prior to the CD diagnosis. Conclusion This study suggests that CD is associated with urticaria, especially chronic urticaria.

show abstract

“…[15–17] Case reports are important for generating hypotheses but offer little evidence of a true association. Previous case-control studies[19, 23, 24] have been contradictory.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Does urticaria risk increase in patients with celiac disease? A large population-based cohort study

Ludvigsson¹,

Lindelöf²,

Rashtak³

et al. 2013

European Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…Although there has been no systematic study of an association between CU and autoimmune diseases, there have been reports of CU patients with vitiligo, pernicious anaemia , rheumatoid arthritis , juvenile rheumatoid arthritis , type 1 diabetes mellitus , Grave's disease , coeliac disease and Raynaud's phenomenon with anticentromere autoantibodies . There have also been many studies describing a high prevalence of IgG antithyroid antibodies ranging from 15% to 30%, and in particular Hashimoto's thyroiditis, among patients with CU .…”

Section: Association With Other Autoimmune Diseasesmentioning

confidence: 99%

EAACI taskforce position paper: evidence for autoimmune urticaria and proposal for defining diagnostic criteria

Konstantinou

Asero

Ferrer

et al. 2012

Allergy

187

160

View full text Add to dashboard Cite

An autoimmune subset of chronic spontaneous urticaria is increasingly being recognized internationally, based on laboratory and clinical evidence that has accrued over the last 20 years. This evidence has been reviewed by a taskforce of the Dermatology section of the European Academy of Allergy and Clinical Immunology. Functional autoantibodies in chronic urticaria (CU) patient sera have been demonstrated against IgE and FceRIa by basophil and mast cell histamine release assays and by basophil activation assays. Antibody specificity has been confirmed by immunoassay, but there is a poor correlation between functionality and immunoreactivity. Approximately 25% of CU patients have a positive basophil histamine release assay and show autoreactivity (a positive autologous serum skin test), whereas 50% are negative regarding both. Functionality of CU sera appears to be complement dependent on mast cells but not exclusively on basophils. Basophil activation by CU sera is predominantly restricted to IgG1 and IgG3 subclasses. Circumstantial evidence for CU being an autoimmune disease comes from an observed association with other autoimmune diseases, a strong association between serum functionality and HLA-DR4 haplotype and the good response of CU patients to immunotherapies. It was proposed that a study should be undertaken to prospectively validate potentially relevant clinical criteria (from the history, examination and routinely available clinical investigations) against a new 'gold standard' for the diagnosis of ACU (positive autoreactivity, functional bioassay and immunoassay) to define preliminary criteria sets for the diagnosis of ACU based on clinical and laboratory features with highest individual sensitivity and specificity.

show abstract

“…10 Atopic disorders were more frequently found in children 11 and adult patients with celiac disease and their relatives than in normal control subjects, 12,13 and urticaria was associated with celiac diseases. [14][15][16] Celiac disease prevalence was found to be increased in a population of atopic patients. 17 On the contrary, one single case-control study in children with celiac disease denies the link between celiac disease and allergy.…”

mentioning

confidence: 96%

“…In fact, more recent studies encompass overt, subclinical, and silent forms of celiac disease, 19 whereas years ago patients were mostly affected by overt malabsorption. 9,[11][12][13]16 To our knowledge, the prevalence of allergy in a large series of adult patients with celiac disease has not been investigated so far.…”

mentioning

confidence: 99%