Chronic unpredictable stress impairs endogenous antioxidant defense in rat brain

Chronic restraint stress increases angiotensin II potency in the rat carotid: role of cyclooxygenases and reactive oxygen species

“…Acute or chronic restraint stress was previously described to reduce the liver catalase activity . The catalase activity was also lower in brain from rats exposed to stress . Taken together with our results, these findings suggest that the exposure to stress induces a depletion of catalase antioxidant activity, which contributes to increase the oxidative damage.…”

“…[17,53,54] The catalase activity was also lower in brain from rats exposed to stress. [55,56] Taken together with our results, these findings suggest that the exposure to stress induces a depletion of catalase antioxidant activity, which contributes to increase the oxidative damage. Our functional studies show a modulatory action of PI 3 K-Akt on AngII-induced contraction in rat carotid.…”

Baicalin Reverses Depressive‐Like Behaviours and Regulates Apoptotic Signalling Induced by Olfactory Bulbectomy

“…Redox state plays a vital role in maintaining homeostasis, and emerging evidence suggests that oxidative stress is highly relevant to the development of depression. The brain consumes more oxygen than nearly any other organ in the body; thus, abnormal oxidative damage increases the susceptibility of neurons to injury (Che et al, 2015). Several studies have shown that olfactory bulbectomy (OBX) markedly induces oxidative damage in the brain, as evidenced by increased levels of malondialdehyde (MDA) and decreased levels of antioxidant components such as superoxide dismutase (SOD) and glutathione peroxidase (GSH) (Song and Leonard, 2005).…”

The evaluation of the changes in enzymatic antioxidant reserves and lipid peroxidation in chosen parts of the brain in an animal model of Parkinson disease

“…Moreover, this study showed that reducing the antioxidant ability and induction of the lipid peroxidation in the cerebral cortex and hippocampus correlates positively with the severity of memory impairment, a decrease in learning abilities and the severity of depression. 26 Looking at this study, it appears likely that the overproduction of free radicals and the progressive nature of PD supports the possibly negative impact of ROS in many areas of the brain, which reflects the appearance of clinical symptoms independent from the deficiency of dopamine and dopaminergic neurons. It is suggested that the overproduction of ROS is associated with a decrease in the antioxidant defense system during aging or as a result of an ongoing disease, which leads to the failure of cell homeostasis.…”