The evaluation of the changes in enzymatic antioxidant reserves and lipid peroxidation in chosen parts of the brain in an animal model of Parkinson disease

Romuk, Ewa; Szczurek, Wioletta; Oleś, Michał; Gabrysiak, Artur; Skowron, Marta; Nowak, Przemysław; Birkner, Ewa

doi:10.17219/acem/63999

Cited by 17 publications

(5 citation statements)

References 22 publications

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“…Anyway, studies in the animal models of PD showed different outcomes compared to the human sample analysis with a degree of controversy [182, 183] probably due to the temporal length of the experimental observation time.…”

Section: Parkinson's Diseasementioning

confidence: 99%

Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View

Cenini

Lloret

Cascella

2019

Oxidative Medicine and Cellular Longevity

363

220

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Age is the main risk factor for a number of human diseases, including neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, which increasing numbers of elderly individuals suffer. These pathological conditions are characterized by progressive loss of neuron cells, compromised motor or cognitive functions, and accumulation of abnormally aggregated proteins. Mitochondrial dysfunction is one of the main features of the aging process, particularly in organs requiring a high-energy source such as the heart, muscles, brain, or liver. Neurons rely almost exclusively on the mitochondria, which produce the energy required for most of the cellular processes, including synaptic plasticity and neurotransmitter synthesis. The brain is particularly vulnerable to oxidative stress and damage, because of its high oxygen consumption, low antioxidant defenses, and high content of polyunsaturated fats very prone to be oxidized. Thus, it is not surprising the importance of protecting systems, including antioxidant defenses, to maintain neuronal integrity and survival. Here, we review the role of mitochondrial oxidative stress in the aging process, with a specific focus on neurodegenerative diseases. Understanding the molecular mechanisms involving mitochondria and oxidative stress in the aging and neurodegeneration may help to identify new strategies for improving the health and extending lifespan.

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Section: Parkinson's Diseasementioning

confidence: 99%

Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View

Cenini

Lloret

Cascella

2019

Oxidative Medicine and Cellular Longevity

363

220

View full text Add to dashboard Cite

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“…Nonmotor symptoms in PD, however, constitute lack of attention, executive dysfunction, working memory issues, and visuo-spatial impairment . Notably, the hippocampus plays an important role in executive function and memory performance suggesting that the hippocampus has a role in PD …”

Section: Introductionmentioning

confidence: 99%

“…3 Notably, the hippocampus plays an important role in executive function and memory performance suggesting that the hippocampus has a role in PD. 20 Our objective is to make a comparative analysis of GSH levels in tandem with susceptibility (metal ions, e.g., iron, etc.) in the SN and hippocampus regions of the PD and agematched control subjects.…”

Section: ■ Introductionmentioning

confidence: 99%

Glutathione Depletion and Concomitant Elevation of Susceptibility in Patients with Parkinson’s Disease: State-of-the-Art MR Spectroscopy and Neuropsychological Study

Shukla,

Goel,

Mandal

et al. 2023

ACS Chem. Neurosci.

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“…Indeed, several studies on post-mortem PD patients’ brains pointed out the accumulation of 4-HNE-protein adducts in the nigrostriatal neurons and LBs [ 16 , 75 ]. Similarly, rat models of PD injected with 6-OHDA displayed significantly increased MDA concentration and acrolein-bound proteins, specifically in the striatum [ 76 , 77 ]. Also, the 4-HNE and MDA content in plasma and cerebrospinal fluid of PD patients was found to be significantly higher compared to healthy subjects, thus hinting at their quantification as potential biomarkers for PD [ 16 , 78 - 80 ].…”

Section: Introductionmentioning

confidence: 99%

Patients Stratification Strategies to Optimize the Effectiveness of Scavenging Biogenic Aldehydes: Towards a Neuroprotective Approach for Parkinson's Disease

Masato

Sandre

Antonini

et al. 2021

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Parkinson’s disease (PD) is a clinically heterogeneous disorder with a multi-factorial pathology. Various molecular mechanisms are involved in the pathogenesis of PD, converging to oxidative stress and proteinopathy. The accumulation of reactive aldehydes (i.e., the dopamine metabolite DOPAL, lipid-peroxidation products, and advanced glycation end-products) has been reported in PD patients’ brains. Aldehydes easily react with primary amines such as lysine residues, which are involved in several regulatory processes in cells. Therefore, aldehyde adducts lead to severe consequences, including neuronal proteostasis, mitochondrial dysfunction, and cell death. In this review, we analyzed the scavenging role of amines toward toxic aldehydes in the brain. Interestingly, small molecules like metformin, rasagiline, hydralazine are already clinically available and used in the therapy for PD and other diseases. Hence, we propose to reevaluate this class of drugs as a disease-modifiers for PD, and we suggest that improved analysis of their pharmacology and bioavailability in the brain, together with a more precise patients stratification, should be considered before planning future clinical trials.

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The evaluation of the changes in enzymatic antioxidant reserves and lipid peroxidation in chosen parts of the brain in an animal model of Parkinson disease

Abstract: Background. Parkinson's disease is a progressive neurodegenerative disorder, characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. The causes of Parkinson's disease are not fully understood; however, increasing evidence implicates oxidative stress.

Cited by 17 publications

References 22 publications

Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View

Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View

Glutathione Depletion and Concomitant Elevation of Susceptibility in Patients with Parkinson’s Disease: State-of-the-Art MR Spectroscopy and Neuropsychological Study

Patients Stratification Strategies to Optimize the Effectiveness of Scavenging Biogenic Aldehydes: Towards a Neuroprotective Approach for Parkinson's Disease

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