Chronic treatment with the new anticonvulsant drug lacosamide impairs learning and memory processes in rats: A possible role of BDNF/TrkB ligand receptor system

Shishmanova-Doseva, Michaela; Peychev, Lyudmil; Koeva, Yvetta; Terzieva, Dora; Georgieva, Katerina; Peychev, Zhivko

doi:10.1016/j.pbb.2018.03.009

Cited by 15 publications

(13 citation statements)

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“…Cognitive unwanted effects can reduce the correlation between QoL and BDNF, increase cellular neogenesis and different AEDs can lead to different cognitive disorders [ 46 ]. This may be explained by different mechanisms, such as the repressive effect of LCM on learning and memory via BDNF/TrkB inhibition [ 47 ], however, ZNS may affect BDNF by unwanted effects rather than hepatotoxicity [ 18 , 23 , 48 ]. The outcome may be due to drugs, such as CBZ and VPA, that elevate ALT.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Roles of New Antiepileptic Drugs and Serum BDNF Levels in Efficacy and Safety Monitoring and Quality of Life: A Clinical Research

Demir

Akarsu

Dede

et al. 2020

CCP

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Objective: We aimed to determine the therapeutic drug monitoring (TDM) features and the relation to Brain-Derived Neurotrophic Factor (BDNF) of frequently used new antiepileptic drugs (NADs) including lamotrigine (LTG), oxcarbazepine (OXC), zonisamide (ZNS) and lacosamide (LCM). Moreover, we investigated their effect on the quality of life (QoL). Methods: Eighty epileptic patients who had been using the NADs, and thirteen healthy participants were included in this cross-sectional study. The participants were randomized into groups. The QOLIE-31 test was used for the assessment of QoL. We also prepared and applied "Safety Test". HPLC method for TDM, and ELISA method for BDNF measurements were used consecutively. Results: In comparison to healthy participants, epileptic participants had lower marriage rate (p=0.049), education level (p˂0.001), alcohol use (p=0.002). BDNF levels were higher in patients with focal epilepsy (p=0.013) and in those with higher education level (p=0.016). There were negative correlations between serum BDNF levels and serum ZNS levels (p=0.042) with LTGpolytherapy, serum MHD levels (a 10-monohydroxy derivative of OXC, p=0.041) with OXCmonotherapy. There was no difference in BDNF according to monotherapy-polytherapy, drugresistant groups, regarding seizure frequency. There was a positive correlation between total health status and QoL (p˂0.001). QOLIE-31 overall score (OS) was higher in those with OXCmonotherapy (76.5±14.5). OS (p˂0.001), seizure worry (SW, p=0.004), cognition (C, p˂0.001), social function (SF, p˂0.001) were different in the main groups. Forgetfulness was the most common unwanted effect. Conclusion: While TDM helps the clinician to use more effective and safe NADs, BDNF may assist in TDM for reaching the therapeutic target in epilepsy.

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Section: Discussionmentioning

confidence: 99%

Investigation of the Roles of New Antiepileptic Drugs and Serum BDNF Levels in Efficacy and Safety Monitoring and Quality of Life: A Clinical Research

Demir

Akarsu

Dede

et al. 2020

CCP

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“…Thus, the action of valproic acid may depend on the extent of pathological changes at the time of treatment onset. Interestingly, a new anticonvulsant drug lacosamide, which has some mechanisms of action in common with valproic acid, induced dose-dependent reduction of the hippocampal expression of BDNF and its receptor (27).…”

Section: Discussionmentioning

confidence: 99%

Brain derived neurotrophic factor expression and DNA methylation in response to subchronic valproic acid and/or aldosterone treatment

et al. 2019

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Aim To test the hypothesis that valproic acid treatment positively affects brain-derived neurotrophic factor (BDNF) expression and DNA methylation in the hippocampus and brain cortex of rats simultaneously treated with aldosterone. Methods Male Sprague-Dawley rats (N = 40) were treated for two weeks with valproic acid (100 mg/1 kg body weight/day) in drinking water and aldosterone (2 μg/100 g body weight/day) or placebo via subcutaneous osmotic minipumps. Results Treatment with valproic acid did not modify BDNF gene expression in the hippocampus but reduced BDNF mRNA levels in the brain cortex. Valproic acid treatment marginally enhanced global DNA methylation in the frontal cortex. BDNF expression negatively correlated with DNA methylation in the hippocampus of valproic acid-treated rats. An unexpected finding was that aldosterone treatment significantly decreased global DNA methylation in the hippocampus. Conclusion The effect of valproic acid on BDNF expression in the brain may depend on the extent of pathological changes present at the time of treatment onset. The observed negative correlation between BDNF expression and DNA methylation in the hippocampus of valproic acid-treated rats encourages further studies.

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“…Although the mechanisms are not fully explained, it is believed that due to its neuroprotective effect, physical exercise successfully counteracts harmful factors, such as distress, intoxication, degenerative changes, and circulatory disturbance, Outdoor Recreation: Physiological Effects and Prevention of Socially Important Diseases DOI: http://dx.doi.org /10.5772/intechopen.93331 which can lead to seizures and impairment of cognitive functions in these patients [50]. Epilepsy itself and most of the antiepileptic medications impair the cognitive functions [51], which requires the search for methods that complement the basic therapy to reduce cognitive deficits. Our previous experimental studies have shown that the regular physical exercise reduces the cognitive deficit from the application of antiepileptic medications and suppresses depression and anxiety behavior in epilepsy [44,51,52].…”

Section: Mental Healthmentioning

confidence: 99%

“…Epilepsy itself and most of the antiepileptic medications impair the cognitive functions [51], which requires the search for methods that complement the basic therapy to reduce cognitive deficits. Our previous experimental studies have shown that the regular physical exercise reduces the cognitive deficit from the application of antiepileptic medications and suppresses depression and anxiety behavior in epilepsy [44,51,52].…”

Section: Mental Healthmentioning

confidence: 99%

Outdoor Recreation: Physiological Effects and Prevention of Socially Important Diseases

Boyadjiev¹,

Georgieva²,

Hristova³

2021

Outdoor Recreation - Physiological and Psychological Effects on Health

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Physical activity improves the condition of the cardiovascular system, respiration, muscles, and metabolism and increases physical working capacity. This review of physiological effects and adaptation mechanisms of the outdoor recreation and its health benefits provides accessible information from a scientific point of view and research practice. Increased frequency of many socially important diseases such as diabetes mellitus type 2, metabolic syndrome and obesity, cardiovascular diseases, and others is associated with dramatically decreased physical activity in the last decades. Outdoor recreation for children, adolescents, adults, and older population is important for the prevention of these conditions. In this chapter, the authors describe in detail the physiological effects of different kinds of outdoor recreation physical activity with different intensities (such as walking, cycling, skiing, rowing, climbing, practicing some outdoor sports, etc.) and assess their benefits in the prevention of socially important diseases.

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Chronic treatment with the new anticonvulsant drug lacosamide impairs learning and memory processes in rats: A possible role of BDNF/TrkB ligand receptor system

Cited by 15 publications

References 53 publications

Investigation of the Roles of New Antiepileptic Drugs and Serum BDNF Levels in Efficacy and Safety Monitoring and Quality of Life: A Clinical Research

Investigation of the Roles of New Antiepileptic Drugs and Serum BDNF Levels in Efficacy and Safety Monitoring and Quality of Life: A Clinical Research

Brain derived neurotrophic factor expression and DNA methylation in response to subchronic valproic acid and/or aldosterone treatment

Outdoor Recreation: Physiological Effects and Prevention of Socially Important Diseases

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