Chronic treatment with angiotensin-converting enzyme inhibitor increases cardiac fibrosis in young rats submitted to early ovarian failure

Dutra, Sabrina Graziani Veloso; Felix, Adriana Maria da Silva; Gastaldi, Ada Clarice; Facioli, Tábata de Paula; Vieira, Suenimeire; Souza, Hugo Celso Dutra de

doi:10.1016/j.autneu.2017.07.001

Cited by 6 publications

(6 citation statements)

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“…The causes of these observations are not yet established and suggest that these morphological and functional adaptations might be associated with the regulation of cardiac autonomic tone balance that favors the vagal autonomic component. Other possible explanations might be related to the reduction in peripheral resistance resulting from the improvement of endothelial function and inflammatory profile and attenuation of the renin-angiotensin-aldosterone system as suggested by some authors ( 8 , 39 , 40 ). However, it is important to note the effects of physical training on cardiac function.…”

Section: Discussionmentioning

confidence: 96%

“…However, little is known about the contribution of ovarian hormones to autonomic and morphofunctional cardiac protection due to SAH. This statement is based on experimental studies that show the importance of ovarian hormones in the regulation of the sympathetic autonomic drive and renin-angiotensin-aldosterone system activity in addition to their important role in endothelial function, fibrosis control, and adverse cardiac hypertrophy ( 5 , 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, regular physical exercise is a non-pharmacological tool in the prevention and control of chronic degenerative diseases including SAH ( 7 , 9 , 10 ). Specifically, the effects on the cardiovascular system of exercise, especially aerobic physical training, include a number of benefits such as reduced blood pressure, improved autonomic tonic balance over the heart, and beneficial cardiac morphological and functional adaptations in addition to the increase in myocardial angiogenesis and optimization of mitochondrial density and endothelial function ( 7 - 9 , 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

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Role of aerobic physical training on cardiac autonomic and morphophysiological dysfunction in hypertensive rats subjected to ovarian hormone deprivation

Rossi

Philbois

Maida

et al. 2022

Braz J Med Biol Res

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Here we investigated the effects of physical training on cardiovascular autonomic control and cardiac morphofunctional parameters in spontaneously hypertensive rats (SHRs) subjected to ovarian hormone deprivation. Forty-eight 10-week-old SHRs were divided into two groups: ovariectomized (OVX, n=24) and sham (SHAM, n=24). Half of each group (n=12) was trained by swimming for 12 weeks (OVX-T and SHAM-T). Cardiac morphology and functionality were assessed using echocardiography, and autonomic parameters were assessed using double pharmacological autonomic block, baroreflex sensitivity (BRS), and analyses of heart rate variability (HRV) and blood pressure variability (BPV). Ovariectomy did not influence the cardiac autonomic tonus balance unlike physical training, which favored greater participation of the vagal autonomic tonus. Ovariectomy and aerobic physical training did not modify HRV and BRS, unlike BPV, for which both methods reduced low-frequency oscillations, suggesting a reduction in sympathetic vascular modulation. Untrained ovariectomized animals showed a reduced relative wall thickness (RWT) and increased diastolic and systolic volumes and left ventricular diameters, resulting in increased stroke volume. Trained ovariectomized animals presented reduced posterior wall thickness and RWT as well as increased final diastolic diameter, left ventricular mass, and stroke volume. Ovarian hormone deprivation in SHRs promoted morphofunctional adaptations but did not alter the evaluation of cardiac autonomic parameters. In turn, aerobic physical training contributed to a more favorable cardiac autonomic balance to the vagal autonomic component and promoted morphological adaptations but had little effect on cardiac functionality.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of aerobic physical training on cardiac autonomic and morphophysiological dysfunction in hypertensive rats subjected to ovarian hormone deprivation

Rossi

Philbois

Maida

et al. 2022

Braz J Med Biol Res

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“…The muscle and skin walls were then sutured with silk thread. Sham mice underwent the same procedure except for the sectioning of the oviducts and the removal of the ovaries [14]. All animals received prophylactic veterinary pentabiotic (2000 U/mL, intramuscular) following the surgical procedures.…”

Section: Ovariectomymentioning

confidence: 99%

Estradiol replacement therapy regulates innate immune response in ovariectomized arthritic mice

Schneider

Kanashiro

Dutra

et al. 2019

International Immunopharmacology

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Neuroendocrine changes are essential factors contributing to the progression and development of rheumatoid arthritis. However, the role of estrogen in the innate immunity during arthritis development is still controversial. Here, we evaluated the effect of estrous cycle, ovariectomy, estradiol replacement therapy and treatment with estrogen receptor (ER)α and ERβ specific agonists on joint edema formation, neutrophil recruitment, and articular levels of cytokines/ chemokines in murine zymosan-induced arthritis. Our results showed that articular inflammation of proestus/estrus was similar to metaestus/diestrus animals indicating that the inflammatory response in acute arthritis is not affected by the estrous cycle. However, ovariectomy increased joint swelling, neutrophil migration, and TNF-α level. Treatment for six consecutive days with estradiol cypionate re-established the acute inflammation in ovariectomized arthritic mice to responses similar to those in SHAM-proestrus/estrus or naive mice. Moreover, treatment with propylpyrazoletriol and diarylpropionitrile, two ERα and ERβ selective agonists, respectively, inhibited both edema and neutrophil recruitment. Finally, the non-genomic properties of estradiol were analyzed with an acute treatment with β-estradiol-water soluble, which reduced the edema only. In the present study, estradiol replacement therapy improves the innate immune responses in ovariectomized arthritic mice by activating nuclear estrogen receptors. These results suggest that *

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“…Esses efeitos são coerentes com outros estudos que observaram prejuízos autonômicos decorrentes da falência ovariana, a exemplo da redução da VFC e da SBR (LIPSITZ et al, 1995;DAVY et al, 1998;HUIKURI et al, 1998;RIBEIRO et al, 2001;ROSA BRITO-ZURITA et al, 2003;NEVES et al, 2007;SUBHASHRI et al, 2020). Os mecanismos de ação envolvidos nesse processo ainda são discutidos, principalmente porque os estrogênios parecem influenciar os diferentes locais envolvidos na regulação autonômica cardíaca, interferindo até mesmo na expressão e/ou na responsividade dos receptores -adrenérgicos, e por fim, afetando a resposta contrátil cardíaca (THAWORNKAIWONG et al, 2003;KAM et al, 2004;SHERWOOD et al, 2010;FELIX et al, 2017).…”

Section: Hormônios Ovarianos E Sistema Cardiovascularunclassified

Estudo dos parâmetros cardiovasculares em mulheres hipertensas, antes e após a menopausa - efeitos da associação do treinamento físico aeróbio com Maleato de Enalapril e Losartan

Duarte¹

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Gostaria de agradecerMeus pais, Mônica e Fernando, pelo amor, apoio incondicional, paciência e por toda a estrutura que me proporcionaram e ainda proporcionam, vocês são meu exemplo de vida.Meu marido, Rudney, por ser meu parceiro e maior incentivador, por comemorar cada pequena conquista e por estar ao meu lado nessa nova jornada que teremos pela frente, como pais.Minha irmã e meu cunhado, Carolina e Daniel, por tudo o que já fizeram e ainda fazem por mim, e agora por me presentearem com um sobrinho que já amo muito, o Gabriel.Prof. Hugo, pela oportunidade de participar do seu laboratório, agradeço muito pela paciência, disponibilidade e dedicação à minha formação, pesquisa e aprimoramento profissional e pessoal. O senhor é uma pessoa que me inspira a ser uma profissional e uma pessoa melhor.Meus colegas e amigos do laboratório, vocês me ajudaram a crescer, me ajudaram durante todo o processo de coleta, além de tornarem meus dias mais divertidos e alegres, mesmo quando tudo estava difícil. Amigos/família que fiz em Ribeirão Preto, muita gratidão por serem minha segunda família, me ouvirem e por me apoiarem nessa jornada. Estão e sempre estarão em meu coração. RESUMO _______________________________________________PHILBOIS-DUARTE, S.V. Estudo dos parâmetros cardiovasculares em mulheres hipertensas, antes e após a menopausa -efeitos da associação do treinamento físico aeróbio com Maleato de Enalapril e Losartan. 104p. Tese

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Chronic treatment with angiotensin-converting enzyme inhibitor increases cardiac fibrosis in young rats submitted to early ovarian failure

Cited by 6 publications

References 64 publications

Role of aerobic physical training on cardiac autonomic and morphophysiological dysfunction in hypertensive rats subjected to ovarian hormone deprivation

Role of aerobic physical training on cardiac autonomic and morphophysiological dysfunction in hypertensive rats subjected to ovarian hormone deprivation

Estradiol replacement therapy regulates innate immune response in ovariectomized arthritic mice

Estudo dos parâmetros cardiovasculares em mulheres hipertensas, antes e após a menopausa - efeitos da associação do treinamento físico aeróbio com Maleato de Enalapril e Losartan

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