Estradiol replacement therapy regulates innate immune response in ovariectomized arthritic mice

Schneider, Ayda Henriques; Kanashiro, Alexandre; Dutra, Sabrina Graziani Veloso; Souza, Raquel do Nascimento de; Veras, Flávio P.; Cunha, Fernando; Ulloa, Luis; Mecawi, André Souza; Reis, L. C.; Malvar, David do Carmo

doi:10.1016/j.intimp.2019.04.048

Cited by 39 publications

(18 citation statements)

References 42 publications

(52 reference statements)

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“…Sex hormones could play an important role. Estradiol promotes innate immune signalling pathways and can enhance production of pro-inflammatory cytokines and chemokines in response to TLR (Toll-like receptor) ligand stimulation of dendritic cells and macrophages [38,39]. This could partly explain the more effective immune response among females.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection

2020

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Background: There is evidence that males have higher incidence rates (IR) of campylobacteriois than females. The objectives of this study were to determine whether these observations differ between age groups and are consistent over different countries and during different time periods. Methods: We obtained data on IRs of campylobacteriosis by sex and age group over a period of 11-26 years from seven countries. Male to female incidence rate ratios (IRR) were computed by age group, country and time period. For each age group, we used meta-analytic methods to combine the IRRs. Sensitivity analysis was used to test whether the results are robust to differences between countries and time periods. Meta-regression was conducted to estimate the different effects of age, country, and time period on the IRR.

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Section: Discussionmentioning

confidence: 99%

Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection

2020

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“…Sex hormones could play an important role. Estradiol promotes innate immune signalling pathways and can enhance production of proin ammatory cytokines and chemokines in response to TLR (Toll-like receptor) ligand stimulation of dendritic cells and macrophages (38,39). This could partly explain the more effective immune response among females.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection.

Green

Schwartz

Peer

2020

Preprint

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Background . There is evidence that males have higher incidence rates (IR) of campylobacteriosis than femlaes. The objectives of this study were to determine whether the sex differences differ between age groups and are consistent over different countries and over different time periods. Methods. We obtained data on incidence rates of campylobacteriosis by sex and age group over a period of 11-26 years from seven countries. Male to female incidence rate ratios (IRR) were computed by age group, country and time period. For each age group, we used meta-analytic methods to combine the IRRs. Sensitivity analysis was used to test whether the results are robust to differences between countries and time periods. Meta-regression was conducted to estimate the different effects of age, country, and time period on the IRR. Results . In the age groups <1, 1-4, 5-9, 10-14, 15-44, 45-64 and 65+ years old, the pooled IRRs (with 95% CI) were 1.31 (1.26-1.37), 1.34 (1.31-1.37), 1.35 (1.32-1.38), 1.73 (1.68-1.79), 1.10 (1.08-1.12), 1.19(1.17-1.21) and 1.27 (1.24-1.30), respectively. For each age group, the excess campylobacteriosis incidence rates in males differed at different age groups. However, despite some quantitative differences between countries, the excess was consistently present over long time-periods. In meta-regression analysis, age group was responsible for almost all the variation in the IRRs. Conclusions . The male predominance in campylobacteriosis incidence rates starts in infancy. This suggests that this is due, at least in part, to physiological or genetic differences and not just behavioural factors. These findings can provide clues to the mechanisms of the infection and could lead to more targeted treatments and vaccine development.

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“…and enhanced by T cells, but resolved by anti-inflammatory cytokines. Estrogen is known to impact on the cytokines in the immune response of innate immunity and anti-inflammatory cytokines (37). They could thus modify the response to infection and contribute to the sex differences in the incidence rates from campylobacteriosis.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection.

Green

Schwartz

Peer

2020

Preprint

View full text Add to dashboard Cite

Background. There is evidence of an excess of males in the incidence rates of campylobacteriois. The objectives of this study were to determine whether these observations differ between age groups and are consistent over different countries and during different time periods. Methods. We obtained data on incidence rates of campylobacteriosis by sex and age group over a period of 11-26 years from seven countries. Male to female incidence rate ratios (IRR) were computed by age group, country and time period. For each age group, we used meta-analytic methods to combine the IRRs. Sensitivity analysis was used to test whether the results are robust to differences between countries and time periods. Meta-regression was conducted to estimate the different effects of age, country, and time period on the IRR. Results. In the age groups <1, 1-4, 5-9, 10-14, 15-44, 45-64 and 65+ years old, the pooled IRRs (with 95% CI) were 1.31 (1.26-1.37), 1.34 (1.31-1.37), 1.35 (1.32-1.38), 1.73 (1.68-1.79), 1.10 (1.08-1.12), 1.19(1.17-1.21) and 1.27 (1.24-1.30), respectively. For each age group, the excess campylobacteriosis incidence rates in males differed at different age groups. However, despite some quantitative differences between countries, the excess was consistently present over long time-periods. In meta-regression analysis, age group was responsible for almost all the variation in the IRRs. Conclusions. The male predominance in campylobacteriosis incidence rates starts in infancy. This suggests that this is due, at least in part, to physiological or genetic differences and not just behavioural factors. These findings can provide clues to the mechanisms of the infection and could lead to more targeted treatments and vaccine development.

show abstract

Estradiol replacement therapy regulates innate immune response in ovariectomized arthritic mice

Cited by 39 publications

References 42 publications

Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection

Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection

Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection.

Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection.

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