Chronic Traumatic Encephalopathy Presenting as Alzheimer’s Disease in a Retired Soccer Player

Grinberg, Lea T.; Anghinah, Renato; Nascimento, Camila; Amaro, Edson; Leite, Renata; Martin, Maria da Graça Morais; Naslavsky, Michel Satya; Takada, Leonel Tadao; Pasqualucci, Carlos Augusto; Nitrini, Ricardo

doi:10.3233/jad-160312

Cited by 51 publications

(66 citation statements)

References 25 publications

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“…The data regarding CTE pathology in soccer are limited to a small number of case studies, or retrospective analyses of brain bank specimens. [96][97][98][99][100][101][102][103] A recent paper by Zuckerman et al has reviewed the data for CTE in contact (soccer, rugby, ice hockey) and collision (American football) sports. 104 Sulcal depth p-tau consistent with the solitary necessary and sufficient CTE criterion was described in about half of the subjects studied, all of whom had comorbid neurodegenerative diseases (eg, Alzheimer's disease, frontotemporal dementias, amyotrophic lateral sclerosis, etc), which makes it difficult to attribute disease onset and progression solely to CTE pathology.…”

Section: Neurodegenerative Disease and Chronic Traumatic Encephalopathymentioning

confidence: 99%

Head Injury in Soccer: From Science to the Field; summary of the head injury summit held in April 2017 in New York City, New York

et al. 2019

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There has been an increased focus and awareness of head injury and sport-related concussion (SRC) across all sports from the medical and scientific communities, sports organisations, legislators, the media and the general population. Soccer, in particular, has been a focus of attention due to the popularity of the game, the frequency of SRC and the hypothesised effects of repetitive heading of the ball. Major League Soccer, US Soccer and the National Women’s Soccer League jointly hosted a conference entitled, ‘Head Injury in Soccer: From Science to the Field’, on 21–22 April 2017 in New York City, New York. The mission of this conference was to identify, discuss and disseminate evidence-based science related to the findings and conclusions of the fifth International Conference on Concussion in Sport held by the Concussion in Sport Group and apply them to the sport of soccer. In addition, we reviewed information regarding the epidemiology and mechanism of head injuries in soccer at all levels of play, data regarding the biomechanics and effects of repetitive head impacts and other soccer-specific considerations. We discussed how to release the information raised during the summit to key stakeholders including athletes, parents, coaches and healthcare providers. We identified future areas for research and collaboration to enhance the health and safety of soccer (football) players.

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Section: Neurodegenerative Disease and Chronic Traumatic Encephalopathymentioning

confidence: 99%

Head Injury in Soccer: From Science to the Field; summary of the head injury summit held in April 2017 in New York City, New York

et al. 2019

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“…Main differential diagnoses for this clinical form encompass all neurodegenerative diseases that target the hippocampus early and preferentially. The long list of differential diagnoses includes cerebral age-related hippocampal sclerosis with TDP-43 (CARTS) 62,108 , primary agerelated tauopathy (PART) 45,109 , argyrophilic grain disease (AGD) 55,110 , atypical forms of frontotemporal lobar degeneration (FTLD) 18,111 including 17q21.31 duplications 112 , MAPT R406W mutations 113 , GRN mutations 114,115 , C9ORF72 hexanucleotide expansions 116 globular glial tauopathy 117 , atypical Lewy body disease 18,118,119 , atypical chronic traumatic encephalopathy 120,121 and PRNP mutation 122,123 (Figure 3). Biomarkers in these cases should help the clinician to address the correct AD diagnosis.…”

Section: -Iwg Typical and Atypical Ad Phenotypesmentioning

confidence: 99%

Alzheimer's Disease Including Focal Presentations

Villain

Dubois

2019

Semin Neurol

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Alzheimer's disease (AD) is the commonest neurodegenerative disease and the most frequent cause of dementia. It affects 30 million people worldwide. Current research criteria focus on biomarkers' status for amyloid and tau using positron emission tomography and cerebrospinal fluid analysis, independent of clinical status. Current epidemiological data, which mostly rely on biomarker-undetermined AD cases, have highlighted ApoE4 and age as the main risk factors. Rare autosomal dominant mutations also account for a small fraction of early-onset AD. The main clinical phenotype at presentation is the amnestic phenotype targeting episodic memory. This is followed by rarer phenotypes such as posterior cortical atrophy, logopenic variant of primary progressive aphasia, frontal variant AD, corticobasal syndrome, and other even rarer presentations mimicking language variants of frontotemporal dementia. Main differential diagnoses include hippocampal sclerosis with TDP-43, primary age-related tauopathy, argyrophilic grain disease, frontotemporal lobar degeneration, Lewy body disease, chronic traumatic encephalopathy as well as nondegenerative disorders such as cerebrovascular disease, chronic alcohol consumption, limbic encephalitis, medial temporal lobe epilepsy, and others. Co-occurrence of AD pathology with other neurodegenerative and vascular diseases is common and increases with age. This presents a challenge in current clinical practice due to a lack of reliable biomarkers for non-AD neurodegenerative diseases.

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“…Although there are unrefuted positive health effects of playing football,1 chronic traumatic encephalopathy (CTE) has been identified in three football players,2 including British player, Jeffrey Astle, causing concern about the long-term effects of repetitive heading. To prevent or mitigate the effects of repetitive football heading, I believe that we must understand the biomechanics and identify strategies for reducing head impact severity 3.…”

Section: Why Did I Do It?mentioning

confidence: 99%

Head accelerations across collegiate, high school and youth female and male soccer players

Caccese

2017

Br J Sports Med

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Chronic Traumatic Encephalopathy Presenting as Alzheimer’s Disease in a Retired Soccer Player

Cited by 51 publications

References 25 publications

Head Injury in Soccer: From Science to the Field; summary of the head injury summit held in April 2017 in New York City, New York

Head Injury in Soccer: From Science to the Field; summary of the head injury summit held in April 2017 in New York City, New York

Alzheimer's Disease Including Focal Presentations

Head accelerations across collegiate, high school and youth female and male soccer players

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