Chronic toxicity of Dursban and its metabolite, 3,5,6-trichloro-2-pyridinol in chickens

Ecological Risk Assessment for Chlorpyrifos in Terrestrial and Aquatic Systems in the United States

“…The major transformation product of hydrolysis of CPY in alkaline soil is 3,5,6-trichloro-2-pyridinol (TCP) . TCP is non-toxic to birds at concentrations greater than what would be encountered in the environment (acute LD 50 >1,000 mg ai kg −1 bwt, chronic LC 50 s of 500-5,600 mg ai kg −1 in the diet) (Campbell et al 1990 ;Long et al 1990 ;Miyazaki and Hodgson 1972 ). Transformation products of TCP are also not toxic to birds at concentrations observed in the environment .…”

Critical Evaluation of Chlorpyrifos’ Breast Cancer Risk

“…Dogs and chickens fed chlorpyrifos or the metabolite TCP were reported to have increased liver weights. However, a histopathological examination into the cause of the liver weight gain was not performed (McCollister et al, 1974;Miyazaki and Hodgson, 1972). One study in cats did not observe any treatment-related lesions, but was of short duration and had a very small number of animals.…”

“…Groups of ten White Leghorn cockerels were fed gelatin capsules containing 1 mg/kg Dursban ® (chlorpyrifos) or 100 mg of the sodium salt of its metabolite TCP three times a week for 30 weeks (Miyazaki and Hodgson, 1972). The livers of the chickens treated with TCP were significantly heavier after 30 weeks of treatment.…”

An Assessment of the Health Risks of Seven Pesticides Used for Termite Control

“…The oral LD 5 0 s of this hydrolysis product are 794 mg/kg for rats and over 1,000 mg/kg for chickens, compared with oral LD 5 0 s of chlorpyrifos of 138-245 mg/kg for rats and 35 mg/kg for chickens (Miyazaki and Hodgson, 1972;WHO, …”

“…is 32-34.8 mg/kg (Gray, 1965;Miyazaki and Hodgson, 1972); for guinea pigs, 500 mg/kg (Gray, 1965); and for rabbits, 1,000-2,000 mg/kg (Gray, 1965). Information on the dermal effects of chlorpyrifos, although minimal, suggests that precautions should be taken to prevent skin contact.…”