Chronic systemic candidiasis

Bodey, Gerald P.; Anaissie, Elias

doi:10.1007/bf01963770

Cited by 60 publications

(40 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, risk factors for invasive fungal infections are not the same in all neutropenic patients (12). Second, chronic systemic candidiasis initiated by neutropenia may persist despite normal PMN counts and adequate antifungal therapy (13). Third, some patients, particularly transplant recipients who have adequate or even normal PMN counts, may be at high risk for invasive mycoses (14).…”

mentioning

confidence: 99%

CD80+Gr-1+ Myeloid Cells Inhibit Development of Antifungal Th1 Immunity in Mice with Candidiasis

Mencacci

Montagnoli

Bacci

et al. 2002

The Journal of Immunology

125

View full text Add to dashboard Cite

To find out whether polymorphonuclear neutrophils (PMN), abundantly recruited in disseminated Candida albicans infection, could directly affect the activation of Th cells we addressed the issues as to whether murine PMN, like their human counterparts, express costimulatory molecules and the functional consequence of this expression in terms of antifungal immune resistance. To this purpose, we assessed 1) the expression of CD80 (B7-1) and CD86 (B7-2) molecules on peripheral, splenic, and inflammatory murine Gr-1+ PMN; 2) its modulation upon interaction with C. albicans in vitro, in vivo, and in human PMN; 3) the effect of Candida exposure on the ability of murine PMN to affect CD4+ Th1 cell proliferation and cytokine production; and 4) the mechanism responsible for this effect. Murine PMN constitutively expressed CD80 molecules on both the surface and intracellularly; however, in both murine and human PMN, CD80 expression was differentially modulated upon interaction with Candida yeasts or hyphae in vitro as well as in infected mice. The expression of the CD86 molecule was neither constitutive nor inducible upon exposure to the fungus. In vitro, Gr-1+ PMN were found to inhibit the activation of IFN-γ-producing CD4+ T cells and to induce apoptosis through a CD80/CD28-dependent mechanism. A population of CD80+Gr-1+ myeloid cells was found to be expanded in conventional as well as in bone marrow-transplanted mice with disseminated candidiasis, but its depletion increased the IFN-γ-mediated antifungal resistance. These data indicate that alternatively activated PMN expressing CD80 may adversely affect Th1-dependent resistance in fungal infections.

show abstract

mentioning

confidence: 99%

CD80+Gr-1+ Myeloid Cells Inhibit Development of Antifungal Th1 Immunity in Mice with Candidiasis

Mencacci

Montagnoli

Bacci

et al. 2002

The Journal of Immunology

125

View full text Add to dashboard Cite

show abstract

“…However, changes in the host environment may lead to opportunistic infections caused by Candida particularly oral, genital and gastrointestinal infections (Bodey, 1993). Infection caused by C. albicans and C. tropicalis can be broadly divided into two categories: Superficial mucocutaneous infections (Ashman and Papadimitriou, 1990) and systematic infections involving the spread of C. albicans to the blood stream (candidemia) and to other major organs (Bodey and Anaissie, 1989). Superficial infections affect various mucous membranes such as in oral and vaginal thrush.…”

Section: Introductionmentioning

confidence: 99%

“…It is believed that the illness is due to minor changes in epithelial environment such as pH, altered glucose/glycogen concentration or changes in epithelial integrity. Candida tropicalis is considered to be one of the leading Candida species, next only to C. albicans, to cause fungemia in patients with cancer (Bodey and Anaissie, 1989;Wingard, 1995). During the 1970s and 1980s, several studies reported that C. tropicalis fungemia, was common in patients with leukemia and in those who had received bone marrow transplants (Abi-Said et al, 1997;Ashman and Papadimitriou, 1990).…”

Section: Introductionmentioning

confidence: 99%

Identification of Putative Therapeutic Targets in Candida tropicalis: An in silico Approach

Ravinaraya¹,

Coico²,

Sundar³

2015

Trends in Bioinformatics

View full text Add to dashboard Cite

The prolonged use of antibiotics results in drug resistance in pathogenic microorganisms. This necessitates the identification of novel drug targets that are useful for the development of effective antimicrobial drugs. In the post-genomic era, computational tools and methods have contributed immensely in identifying such novel targets, thereby accelerating the drug discovery process. In the present study, an extensive in silico analysis of the proteome of the pathogenic yeast, Candida tropicalis was performed to identify potential drug targets. The complete proteome of C. tropicalis retrieved from Uniprot was analysed using the CD-HIT algorithm followed by BLAST for eliminating proteins homologous to human proteome. The selected proteins were then analyzed using DEG database for identifying critical genes for the survival. The identified essential proteins were subjected to pathway analysis using KEGG to predict their involvement in metabolism. This approach resulted in the identification of 20 potential drug targets present in C. tropicalis.

show abstract

“…The yeast Candida albicans is a major opportunistic pathogen, the prevalance of which is increasing in virtually all groups of immunosuppressed or immunocompromised patients (1). Although clinical observations have consistently indicated that candidiasis occurs in association with defective cell-mediated immune responses, the relationship has been difficult to analyse either in human subjects or in experimental animals, and consequently is still rather contentious.…”

Section: Introducnonmentioning

confidence: 99%

Murine candidiasis: Cell‐mediated immune responses correlate directly with susceptibility and resistance to infection

Ashman

1990

Immunology & Cell Biology

View full text Add to dashboard Cite

Summary Cell-mediated immune responses were evaluated after immunization in two inbred mouse strains, CBA/H and BALB/c. that are respectively susceptible and resistant to infection with the yeast Candida atbicans. Local immune responses, as measured by leucocytic infiltration into the draining lymph node, were similar; however, both delayed-type hypersensitivity responses and candida-specific lymphocyte proliferation in vitro were significantly stronger in the resistant strain. The response was controlled by genes mapping outside the major histocompatibility complex. A possible explanation for the down regulation of the immune response in CBA/H mice is discussed.

show abstract

Chronic systemic candidiasis

Cited by 60 publications

References 18 publications

CD80+Gr-1+ Myeloid Cells Inhibit Development of Antifungal Th1 Immunity in Mice with Candidiasis

CD80+Gr-1+ Myeloid Cells Inhibit Development of Antifungal Th1 Immunity in Mice with Candidiasis

Identification of Putative Therapeutic Targets in Candida tropicalis: An in silico Approach

Murine candidiasis: Cell‐mediated immune responses correlate directly with susceptibility and resistance to infection

Contact Info

Product

Resources

About