Murine candidiasis: Cell‐mediated immune responses correlate directly with susceptibility and resistance to infection

Ashman, R. B.

doi:10.1038/icb.1990.2

Cited by 33 publications

(20 citation statements)

References 27 publications

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“…An important observation in this experimental system is that memory T cell responses, such as delayed-type hypersensitivity and Candida-specific lymphocyte proliferation, show a direct correlation with disease susceptibility (7). In contrast to the primary infection, the magnitude of memory T cell responses appears to be governed by non-MHC genes.…”

Section: Introductionmentioning

confidence: 99%

Murine candidiasis: Susceptibility is associated with the induction of T cell‐mediated, strain‐specific autoreactivity

Ashman¹

1990

Immunology & Cell Biology

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Summary Inbred mice can be classified as susceptible or resistant to systemic infection with the yeast Candida albicans by histopathological evaluation of tissue lesions. Candida-specific memory T cell responses generated by resistant BALB/c mice are vigorous and sustained, whereas those displayed by susceptible CBA/H mice are weak. When spleen cells from immune mice were activated by culture with Candida antigens in vitro, and injected into syngeneic and allogeneic recipients in the absence of further antigenic stimulation, cells from CBA/H mice induced a specific inflammatory response only in CBA/H recipients. In contrast, cells from immune BALB/c mice showed no specific activity. The effector cells were identified as T cells of the cytotoxic/suppressor subclass (CD4-, CD8+); and analysis in various Fl hybrid mice showed that reactivity was expressed only in animals carrying CBA/H genes. The data thus indicate that susceptibility to C albicans infection is associated with the induction of a T cell subpopulation that has the potential to react specifically against unmodified self antigens expressed by the susceptible strain.

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Section: Introductionmentioning

confidence: 99%

Murine candidiasis: Susceptibility is associated with the induction of T cell‐mediated, strain‐specific autoreactivity

Ashman¹

1990

Immunology & Cell Biology

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“…Por SU parte, las células efectoras fueron, probablemente, leucocitos polimorfonucleares (PMN), lo cual parece consistente con la demostración de una susceptibilidad aumentada a la candidiasis sistémica en ratones mutantes beige, los cuales tienen un defecto en la generación de PMN (66). Como se anotó anteriormente, es probable que la magnitud del daño tisular esté ligada a respuestas inflamatorias mediadas por el neutrófilo (53).…”

Section: (32)unclassified

Participación del polimorfonuclear neutrófilo en la respuesta inmune contra Paracoccidioides brasiliensis

González

Cano

2001

biomedica

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~o@oración para lnvestigaciones ~ibló~icas, Medellín, ~olombii. Vscuela de Bacteriología y Laboratorio Clínico, Universidad de Antioquia, Medellín, Colombia La paracoccidioidomicosis, micosis profunda de gran importancia en Latinoamérica, se caracteriza por presentar una respuesta inflamatoria aguda en el pulmón, órgano blanco del proceso infeccioso. En las etapas iniciales, esta respuesta se caracteriza principalmente por un infiltrado de polimorfonucleares neutrófilos (PMN), los que, de acuerdo con estudios histopatológicos y de lavados broncoalveolares, representan más del 85% de las células allí presentes. Las evidencias presentadas en esta revisión sugieren que el PMN participa activamente en la respuesta inflamatoria aguda inducida por Paracoccidioides brasiliensis, como lo demuestra la inhibición de su crecimiento después de su interacción con tales PMN. Igualmente, se conoce que algunas etapas del mecanismo fungicida exhibido por esta célula fagocítica están mediadas por los reactivos intermediarios del oxígeno, así como también por el efecto activador de algunas citocinas como IFN y, GM-CSF e IL-lb. En efecto, fracciones o componentes del hongo inducen la migración al sitio inflamatorio y la activación de los PMN, evidenciada por el aumento en los productos del estallido respiratorio.Palabras clave: polimorfonuclear neutrófilo, Paracoccidioides brasiliensis, paracoccidioidomicosis, estallido respiratorio, respuesta inflamatoria. Polymorphonuclear neutrophil participation in immune response t o Paraccocidioides brasiliensisParacoccidioidomycosis, a systemic mycosis of great importance in Latin America, is histologically characterized by an acute inflammatoty response in the lung target organ. During the early stages of infection, tissue response is mainly characterized by the presence of polymorphonuclear neutrophils (PMN) which represent over 85% of al1 cells (demonstrated by histopathology and bronchoalveolar lavage). Evidence is presented herein that PMNs actively participate during the acute inflammatory response induced by Paracoccidioides brasiliensis. This is shown by growth inhibition following the interaction of the fungus with these phagocytic cells. Certain of the killing mechanisms exhibited by this phagocytic cell are mediated by the reactive oxygen intermediates, as well as by the activating mechanisms exerted by certain cytokines (IFN-y, GM-CSF and IL-1 P). Furthermore, fungal fractions or components are capable of inducing both activation of PMN and migration to the inflammatory site as revealed by the increase of the products resulting from the respiratoty burst.

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“…The genetic background of the mice influences the nature and magnitude.of C*d'd1-specific memory responses ln systemlc infection, in that the susceptible CBAJCaH mice tend to show lower cell-mediated immune responses (Ashman, 1990)' but greater levels of antibody-mediated protection (Ashman and Papadimitriou, 1988) than the more resistant BALB/c strain' However, following oral infection, Candida-speclftc DTH responses developed in the relatively infection-proneDBN2, but not in the more resistant BALB/c mice (Chakir et al', 1994)' Humoral immune responses were detectable after infection had resolved (Elahi et al', 2000), but levels of serum IgG and salivary IgA antibodies were higher in BALB/c than in DBAJ2 mice. In neonatal micg primary infection of the GI tract primed them for enhanced DTH responses and conferred protection from systemic challenge as adults (Domer, 1988), whereas adult mice infected via the oral cavity, but not intravenously, were protected against a second oral infection (narah, unpublished data).…”

Section: Experimental Immunity and Protectionmentioning

confidence: 99%

Oral Candidiasis: Clinical Manifestations and Cellular Adaptive Host Responses

Ashman

Farah

2005

Fungal Immunology

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Murine candidiasis: Cell‐mediated immune responses correlate directly with susceptibility and resistance to infection

Cited by 33 publications

References 27 publications

Murine candidiasis: Susceptibility is associated with the induction of T cell‐mediated, strain‐specific autoreactivity

Murine candidiasis: Susceptibility is associated with the induction of T cell‐mediated, strain‐specific autoreactivity

Participación del polimorfonuclear neutrófilo en la respuesta inmune contra Paracoccidioides brasiliensis

Oral Candidiasis: Clinical Manifestations and Cellular Adaptive Host Responses

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