Chronic supplementation of beta-hydroxy-beta methylbutyrate (HMβ) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in rats

Gerlinger-Romero, Frederico; Guimarães‐Ferreira, Lucas; Giannocco, Gisele; Nunes, Maria Tereza

doi:10.1016/j.ghir.2010.12.006

Cited by 72 publications

(84 citation statements)

References 45 publications

(56 reference statements)

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“…In the present study, HMB supplementation does not change muscle mass suggesting that the improvement on strength production was due to increased intrinsic capacity of single skeletal muscle fibers to generate force and not by change in muscle mass. The lack of effect of HMB supplementation on muscle mass in the present study is in accordance to previous reports (Gerlinger-Romero et al 2011). HMB supplementation does not change contraction time and relaxation time suggesting no effects on Ca 2?…”

Section: Discussionsupporting

confidence: 93%

“…We demonstrate previously that HMB supplementation at the same dose used in the present study increased the activity of GH/ IGF-1 axis demonstrating by increased the content of pituitary GH mRNA and GH protein, hepatic IGF-1 mRNA and serum IGF-1 concentration (Gerlinger-Romero et al 2011). IGF-1 stimulates glycogen synthesis in skeletal muscle by inactivation of glycogen synthase kinase-3 (GSK3) through phosphoinositide 3-kinase (PI3K) pathway (Cross et al 1994).…”

Section: Discussionsupporting

confidence: 51%

“…The more significant effect of HMB supplementation on oxidative muscle fibers can be due to increased lipid availability due to increased lipolysis. We reported previously (Gerlinger-Romero et al 2011) that HMB supplementation decreased the content of epididymal adipose tissue without change body mass gain in rats. An increase in plasma free fatty acid (FFA) concentration was c Specific muscle tetanic force normalized per muscle mass.…”

Section: Discussionmentioning

confidence: 92%

“…This dose of HMB increased survival time, induced important metabolic changes in cancer-bearing animals and is considered safe for rats (Baxter et al 2005). In addition, this dose does not change body weight gain in rats (Gerlinger-Romero et al 2011). After this period, placebo-treated (n = 6) and HMB-treated (n = 6) animals were subjected to analysis of maximum muscle strength (twitch and tetanic forces) production, contractile properties and resistance to acute muscle fatigue and the remainder (n = 6 for each group) were killed by decapitation and analysis of ATP and glycogen content and citrate synthase activity in red and white portions of gastrocnemius muscle.…”

Section: Hmb Supplementation Protocolmentioning

confidence: 86%

“…We used herein a HMB supplementation protocol that was previously described (Caperuto et al 2007;Gerlinger-Romero et al 2011). The dose of 320 mg/kg BW per day of HMB supplementation (calcium salt: Optimum Nutrition, Sunrise, FL, USA) was carried out by gavage in a volume of 1 ml saline for 4 weeks.…”

Section: Hmb Supplementation Protocolmentioning

confidence: 99%

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Metabolic and functional effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation in skeletal muscle

et al. 2011

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Beta-hydroxy-beta-methylbutyrate (HMB) is a metabolite derived from leucine. The anti-catabolic effect of HMB is well documented but its effect upon skeletal muscle strength and fatigue is still uncertain. In the present study, male Wistar rats were supplemented with HMB (320 mg/kg per day) for 4 weeks. Placebo group received saline solution only. Muscle strength (twitch and tetanic force) and resistance to acute muscle fatigue of the gastrocnemius muscle were evaluated by direct electrical stimulation of the sciatic nerve. The content of ATP and glycogen in red and white portions of gastrocnemius muscle were also evaluated. The effect of HMB on citrate synthase (CS) activity was also investigated. Muscle tetanic force was increased by HMB supplementation. No change was observed in time to peak of contraction and relaxation time. Resistance to acute muscle fatigue during intense contractile activity was also improved after HMB supplementation. Glycogen content was increased in both white (by fivefold) and red (by fourfold) portions of gastrocnemius muscle. HMB supplementation also increased the ATP content in red (by twofold) and white (1.2-fold) portions of gastrocnemius muscle. CS activity was increased by twofold in red portion of gastrocnemius muscle. These results support the proposition that HMB supplementation have marked change in oxidative metabolism improving muscle strength generation and performance during intense contractions.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 92%

Section: Hmb Supplementation Protocolmentioning

confidence: 86%

Section: Hmb Supplementation Protocolmentioning

confidence: 99%

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Metabolic and functional effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation in skeletal muscle

et al. 2011

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Nutraceuticals Approach as a Treatment for Cancer Cachexia

Chiocchetti¹,

Viana²,

Lopes‐Aguiar³

et al. 2022

Handbook of Nutraceuticals and Natural Products

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Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions

Holeček

2017

J cachexia sarcopenia muscle

190

154

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Beta‐hydroxy‐beta‐methylbutyrate (HMB) is a metabolite of the essential amino acid leucine that has been reported to have anabolic effects on protein metabolism. The aims of this article were to summarize the results of studies of the effects of HMB on skeletal muscle and to examine the evidence for the rationale to use HMB as a nutritional supplement to exert beneficial effects on muscle mass and function in various conditions of health and disease.The data presented here indicate that the beneficial effects of HMB have been well characterized in strength‐power and endurance exercise. HMB attenuates exercise‐induced muscle damage and enhances muscle hypertrophy and strength, aerobic performance, resistance to fatigue, and regenerative capacity. HMB is particularly effective in untrained individuals who are exposed to strenuous exercise and in trained individuals who are exposed to periods of high physical stress. The low effectiveness of HMB in strength‐trained athletes could be due to the suppression of the proteolysis that is induced by the adaptation to training, which may blunt the effects of HMB. Studies performed with older people have demonstrated that HMB can attenuate the development of sarcopenia in elderly subjects and that the optimal effects of HMB on muscle growth and strength occur when it is combined with exercise. Studies performed under in vitro conditions and in various animal models suggest that HMB may be effective in treatment of muscle wasting in various forms of cachexia. However, there are few clinical reports of the effects of HMB on muscle wasting in cachexia; in addition, most of these studies evaluated the therapeutic potential of combinations of various agents. Therefore, it has not been possible to determine whether HMB was effective or if there was a synergistic effect. Although most of the endogenous HMB is produced in the liver, there are no reports regarding the levels and the effects of HMB supplementation in subjects with liver disease. Several studies have suggested that anabolic effects of HMB supplementation on skeletal muscle do not occur in healthy, non‐exercising subjects.It is concluded that (i) HMB may be applied to enhance increases in the mass and strength of skeletal muscles in subjects who exercise and in the elderly and (ii) studies examining the effects of HMB administered alone are needed to obtain conclusions regarding the specific effectiveness in attenuating muscle wasting in various muscle‐wasting disorders.

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Chronic supplementation of beta-hydroxy-beta methylbutyrate (HMβ) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in rats

Cited by 72 publications

References 45 publications

Metabolic and functional effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation in skeletal muscle

Metabolic and functional effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation in skeletal muscle

Nutraceuticals Approach as a Treatment for Cancer Cachexia

Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions

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