Chronic Stress-Related Neural Activity Associates With Subclinical Cardiovascular Disease in Psoriasis

Goyal, Aditya; Dey, Amit; Chaturvedi, Abhishek; Elnabawi, Youssef; Aberra, Tsion; Chung, Jonathan; Belur, Agastya D.; Groenendyk, Jacob; Lerman, Joseph B; Rivers, Joshua; Rodante, Justin; Harrington, Charlotte; Varghese, Nevin; Sanda, Gregory E.; Baumer, Yvonne; Sorokin, Alexander V.; Teague, Heather; Genovese, Leonard; Natarajan, Balaji; Joshi, Aditya; Playford, Martin P.; Bluemke, David A.; Chen, Marcus Y; Alavi, Abass; Pitman, Roger K.; Powell‐Wiley, Tiffany M.; Tawakol, Ahmed; Gelfand, Joel M.; Mehta, Nehal N.

doi:10.1016/j.jcmg.2018.08.038

Cited by 60 publications

(54 citation statements)

References 41 publications

(70 reference statements)

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“…Moreover, individual differences in amygdala function have been associated with clinical cardiovascular endpoints, cardiometabolic outcomes that are conducive to atherosclerotic CVD and even surrogate markers of pre-clinical atherosclerosis that are all presaged by autonomic, immune and neuroendocrine dysregulation. Elevated resting metabolic activity of the amygdala, for example, confers risk for cardiovascular events ( Tawakol et al., 2017 ), incident diabetes ( Osborne et al., 2019 ), the progression of visceral adiposity ( Ishai et al., 2019 ) and non-calcified coronary plaque ( Goyal et al., 2018 ). The latter findings build on earlier cross-sectional evidence that pre-clinical atherosclerosis in the carotid arteries associates with elevated metabolic activity in the medial temporal lobe ( Sojkova et al., 2010 ) and—more specifically—with amygdala reactivity to facial expressions of fear and anger ( Gianaros et al., 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Affective brain patterns as multivariate neural correlates of cardiovascular disease risk

Gianaros

Kraynak

Kuan

et al. 2020

Social Cognitive and Affective Neuroscience

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Abstract This study tested whether brain activity patterns evoked by affective stimuli relate to individual differences in an indicator of pre-clinical atherosclerosis: carotid artery intima-media thickness (CA-IMT). Adults (aged 30–54 years) completed functional magnetic resonance imaging (fMRI) tasks that involved viewing three sets of affective stimuli. Two sets included facial expressions of emotion, and one set included neutral and unpleasant images from the International Affective Picture System (IAPS). Cross-validated, multivariate and machine learning models showed that individual differences in CA-IMT were partially predicted by brain activity patterns evoked by unpleasant IAPS images, even after accounting for age, sex and known cardiovascular disease risk factors. CA-IMT was also predicted by brain activity patterns evoked by angry and fearful faces from one of the two stimulus sets of facial expressions, but this predictive association did not persist after accounting for known cardiovascular risk factors. The reliability (internal consistency) of brain activity patterns evoked by affective stimuli may have constrained their prediction of CA-IMT. Distributed brain activity patterns could comprise affective neural correlates of pre-clinical atherosclerosis; however, the interpretation of such correlates may depend on their psychometric properties, as well as the influence of other cardiovascular risk factors and specific affective cues.

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Section: Introductionmentioning

confidence: 99%

Affective brain patterns as multivariate neural correlates of cardiovascular disease risk

Gianaros

Kraynak

Kuan

et al. 2020

Social Cognitive and Affective Neuroscience

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“…Indeed, psoriasis is associated with a variety of comorbidities including metabolic syndrome, cardiovascular diseases (CVDs), inflammatory bowel diseases, and various other systemic conditions. [2][3][4][5][6][7][8][9][10] C-reactive protein (CRP) is a polypeptide and acute-phase reactant synthesized mainly by the hepatocytes during inflammation in response to certain cytokines, such as interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α. [11][12][13][14] High-sensitivity CRP (hs-CRP) can show small changes in CRP levels during inflammation; therefore, it is a much more sensitive marker than CRP.…”

Section: Introductionmentioning

confidence: 99%

High‐sensitivity C‐reactive protein as a biomarker in detecting subclinical atherosclerosis in psoriasis

Niknezhad

Haghighatkhah

Zargari

et al. 2020

Dermatologic Therapy

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Psoriasis is known to be associated with increased risk of cardiovascular diseases. High‐sensitivity C‐reactive protein (hs‐CRP) is a marker of inflammation and an independent risk factor for atherosclerosis. We aimed to assess the correlation between hs‐CRP and subclinical atherosclerosis in psoriatic patients. In 60 patients with moderate to severe psoriasis and 60 age‐ and gender matched healthy controls, we evaluated the serum hs‐CRP level and mean intima‐media thickness of the common carotid artery (MIMT‐CCA). Psoriatic patients had higher levels of hs‐CRP (median, 2.25 mg/L; IQR, 0.98‐3.80; and range, 0.29‐11.60) than did those in the control group (median, 1.03 mg/L; IQR, 0.36‐2.15; and range, 0.10‐3.35). Psoriatic patients also had higher mean MIMT (0.74 ± 0.19 and 0.54 ± 0.12, respectively, and P < .0001) compared with healthy subjects. The serum level of hs‐CRP was significantly correlated with MIMT (P < .0001). Our results indicate that psoriatic patients have a higher risk of subclinical atherosclerosis and hs‐CRP may be a useful marker for future risk of cardiovascular diseases in these patients. So, not only does anti‐inflammatory drugs play a key role in the treatment of psoriasis, but also they may reduce the risk of cardiovascular diseases by decreasing level of inflammatory markers including hs‐CRP.

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“…Increased amygdalar metabolic activity induced through sympathetic nervous system pathways the activation of the bone marrow and thus boosted the release of inflammatory cells with the consequence of increased vascular inflammation [ 63 ]. The same pathways were elucidated in a sample of patients with psoriasis, a chronic inflammatory skin disease: Increased metabolic activity of the amygdala led to hematopoietic system activation with increased release of activated monocytes stimulating inflammation and atherosclerosis [ 11 ]. Other neuroimaging studies showed that amygdala activity was associated with baseline visceral adiposity as well as an increase in visceral adiposity [ 17 ], and the development of diabetes mellitus independent from adiposity [ 48 ].…”

Section: Amygdala Activation and Inflammationmentioning

confidence: 99%

The fear-defense system, emotions, and oxidative stress

Kerahrodi

Michal

2020

Redox Biology

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Psychosocial stress has a profound impact on well-being and health. The response to stress is associated mainly with the amygdala, a crucial structure of the fear-defense system, essential for social cognition and emotion regulation. Recent neuroimaging-studies demonstrated how an increased metabolic activity of the amygdala enhances inflammation, and leads to cardiometabolic disease. The development of therapeutic strategies depends on our understanding of both which factors activate the fear-defense system and the subsequent molecular mechanisms that translate emotional stress into cell damage. Fear of emotions as an aftermath of attachment trauma is the most important trigger of the maladaptive activation of the fear-defense system. The central molecular pathways are enhanced myelopoiesis and upregulated proinflammatory gene expression, glucocorticoid and insulin resistance, and oxidative stress. Therapeutic strategies may benefit from holistic approaches. Psychotherapy can reduce the maladaptively increased activation of the fear-defense system. Biological interventions can buffer the detrimental effects of oxidative stress in the organism.

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Chronic Stress-Related Neural Activity Associates With Subclinical Cardiovascular Disease in Psoriasis

Cited by 60 publications

References 41 publications

Affective brain patterns as multivariate neural correlates of cardiovascular disease risk

Affective brain patterns as multivariate neural correlates of cardiovascular disease risk

High‐sensitivity C‐reactive protein as a biomarker in detecting subclinical atherosclerosis in psoriasis

The fear-defense system, emotions, and oxidative stress

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