Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study

Tharwat, Dahlia; Trousselard, Marion; Balès, M.; Sutter-Dallay, Anne-Laure; Fromage, Dominique; Spitz, Élisabeth; Dallay, D.; Harvey, Thierry; Welter, Eric; Coatleven, F.; Cherier, Lydie; Teissèdre, F.; Pouly, Jean-Luc; Dutheil, Frédéric; Duffaud, Anaïs

doi:10.1136/bmjopen-2017-018317

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…We showed no difference between the type of fluid and the analysis technique, which prompted us to prefer saliva sampling. Saliva sampling is very convenient in research because it is a noninvasive method (48)(49)(50)(51). Several studies have investigated the relationship between stress and dehydroepiandrosterone levels.…”

Section: Dhea Is a Biomarker Of Stressmentioning

confidence: 99%

DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis

et al. 2021

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Background: Psychosocial stress is a significant public health problem inducing consequences for quality of life. Results about the use of dehydroepiandrosterone (DHEA) as a biomarker of acute stress are conflicting. We conducted a systematic review and meta-analysis to demonstrate that DHEA levels could be a biomarker of stress.Methods: PubMed, Cochrane Library, Embase, and ScienceDirect databases were searched on March 19, 2021 using the keywords “acute stress” AND “DHEA” OR “Dehydroepiandrosterone.” Articles needed to describe our primary outcome, i.e., induction of acute stress and at least two measures of DHEA.Results: We included 14 studies, with a total of 631 participants, in our meta-analysis. The DHEA levels increased overtime after acute stress [standardized mean difference (SMD) = 1.56, 95%CI = 1.13–1.99]. Stratification by time showed a main peak at the end of stress (SMD = 2.43, 95%CI = 1.59–3.27), followed by a progressive decrease (coefficient = −0.11, 95%CI = −0.19 to −0.17, p = 0.020). There was no significant change 1 h after the end of acute stress. Metaregressions showed an impact of mental stress (SMD = 2.04, 95%CI = 1.43–2.65), sex (SMD = 0.02, 95%CI = 0.00–0.04), age (SMD = −0.12, 95%CI = −0.2 to −0.05), and obesity (SMD = 0.31, 95%CI = −0.00 to 0.63). There was no difference whatever the type of fluid (blood or saliva) and the measurement technique used.Conclusions: DHEA is a biomarker of acute stress, with a short-term increase (1 h). DHEA increases following acute mental stress, whatever the type and duration of mental stress. Women, young people, and obese individuals had a higher response. Blood and saliva measures were comparable.

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Section: Dhea Is a Biomarker Of Stressmentioning

confidence: 99%

DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis

et al. 2021

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The Impact of a Mindfulness App on Postnatal Distress

2022

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Objectives The present study investigated the effectiveness of an 8-week mindfulness mobile phone app on women’s depression, anxiety, stress and mindful attention/awareness in the postnatal period. Methods The study enrolled 99 mothers of a child under 1 year old, and randomly assigned them to intervention (n = 49, mean age = 31.11, SD = 4.30, years) and control (n = 50, mean age = 31.35, SD = 5.29, years) groups. Multiple regression examined intervention effects on depression, anxiety, stress and mindful attention/awareness measured post-intervention and at 4-week follow-up, controlling for the baseline and post-intervention measurement of the specific outcome, respectively. Results The intervention group showed significant decreases in depression, anxiety and stress levels and an increase of mindful attention/awareness post-intervention compared to the control group, with medium to large effect sizes after controlling for effects of corresponding variables at baseline. The intervention group showed further decrease in depression and stress levels and an increase in mindful attention/awareness at 4 weeks post-intervention compared to the control group, with small to medium effect sizes, after controlling for effects of corresponding variables at post-intervention. Conclusions The outcomes of the study suggest that delivery of mindfulness via smartphones could be a viable and affordable resource for reducing postnatal depression, anxiety and stress.

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Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study

Cited by 2 publications

References 33 publications

DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis

DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis

The Impact of a Mindfulness App on Postnatal Distress

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