Chronic stress-induced elevation of IL-1β in the saliva and submandibular glands of mice

Paudel, Durga; Morikawa, Tetsuro; Yoshida, Koki; Uehara, Osamu; Giri, Sarita; Neopane, Puja; Khurelchuluun, Ariuntsetseg; Hiraki, Daichi; Sato, Jun

doi:10.1007/s00795-020-00250-w

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…Salivary proteins such as alpha-amylase, cortisol, dehydroepiandrosterone, IL-1β, IL-6, TNF-α, and IL-10 have been shown to alter during psychological stress conditions in humans [80] , [81] , [82] , [83] , [84] . Recently, we have demonstrated that chronic stress in mice models induces an increase in inflammatory cytokines such as IL-1β and IL-6 in the salivary gland and saliva [85] . The altered salivary proteins, mainly inflammatory cytokines may alter the oral microbiome.…”

Section: Psychological Stress and Oral Microbesmentioning

confidence: 99%

Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis

Paudel

Uehara²,

Giri³

et al. 2022

Japanese Dental Science Review

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Section: Psychological Stress and Oral Microbesmentioning

confidence: 99%

Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis

Paudel

Uehara²,

Giri³

et al. 2022

Japanese Dental Science Review

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“…Furthermore, Martínez et al 17 showed that fear and chronic stress were related to elevated levels of proinflammatory cytokines in healthy individuals. A study in mice also showed chronic stress‐induced elevation of IL‐1β in saliva 18 …”

Section: Introductionmentioning

confidence: 98%

Possible utilization of salivary IFN‐γ/IL‐4 ratio as a marker of chronic stress in healthy individuals

Takemori

Sasayama

Toida

et al. 2021

Neuropsychopharm Rep

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Introduction Several studies show that psychological stress reduces Th1/Th2 ratio in blood samples. However, evidence is scarce regarding the cytokine alterations during stress in saliva. We investigated the influence of chronic stress on Th1/Th2 ratio and cytokine profiles in the saliva of healthy individuals. Further, we examined the associations of the salivary cytokine levels with sleep and attention problems, which are closely related with psychological stress. Methods Salivary levels of 27 cytokines were measured by multiplex bead array assays in 31 healthy young individuals (health science students and hospital staff consisting of 11 men and 20 women, mean age [standard deviation] =21.5 [0.8] years). The Kessler Psychological Distress scale (K10) and Athens Insomnia Scale (AIS) were administered to assess subjective chronic psychological stress and sleep problems. Further, participants were asked to wear Actigraph GT3X accelerometers for 3 days to assess the total sleep time. Attention problems were assessed by administering the Integrated Visual and Auditory Continuous Performance Test (IVA‐CPT). Results Thirteen cytokines with >80% detectable results were included in the main analyses. The IFN‐γ/IL‐4 ratio, which is a commonly used index for Th1/Th2 ratio, showed significant negative correlations with the K10 and AIS scores. None of the cytokines were significantly associated with sex, body mass index, sleep index measured by Actigraph, or IVA‐CPT scores. Conclusion Chronic stress may be associated with alterations of the Th1/Th2 balance in salivary cytokine production. IFN‐γ/IL‐4 ratio in saliva may serve as a potential biomarker of chronic stress in healthy individuals.

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“…In the previous studies, objective methods using biomarkers and subjective methods using questionnaires were used to evaluate psychological stress. Measurement of cytokines in saliva has been shown to be useful as an objective method of assessing psychological stress [ 7 ]. The stress response is also associated with increased neural activity in the hypothalamus-pituitary-adrenal axis or the sympathetic-adrenal medulla axis, resulting in the release of cortisol from the adrenal cortex [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Psychological Stress Determined by Voice Analysis and Periodontal Status: A Cohort Study

Maruyama

Ekuni

Higuchi

et al. 2022

IJERPH

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In modern society, evaluation and management of psychological stress may be important for the prevention of periodontal disease. The purpose of this study was to examine the relationship between psychological stress (vitality and mental activity) evaluated by Mind Monitoring System (MIMOSYS) and periodontal status. Forty students of Okayama University underwent the oral examination and self-reported questionnaire on the first day (baseline) and the 14th day (follow-up). Voice recording was performed every day with the MIMOSYS app during the whole study period. The participants completed the Patient Health Questionnaire (PHQ)-9 and Beck Depression Inventory (BDI) at baseline and at follow-up. Spearman’s rank correlation coefficient was used to determine the significance of correlations among variables. The PHQ-9 and BDI scores were negatively correlated with vitality in the morning. Change in vitality in the morning was significantly correlated with changes in periodontal inflammation. Mental activity was significantly correlated with change in mean probing pocket depth. This result shows that measurement of psychological stress using a voice-based tool to assess mental health may contribute to the early detection of periodontal disease.

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Chronic stress-induced elevation of IL-1β in the saliva and submandibular glands of mice

Cited by 5 publications

References 21 publications

Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis

Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis

Possible utilization of salivary IFN‐γ/IL‐4 ratio as a marker of chronic stress in healthy individuals

Relationship between Psychological Stress Determined by Voice Analysis and Periodontal Status: A Cohort Study

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