Chronic spontaneous urticaria is not an allergic disease

Chronic urticaria and atopic disorders: a cross-sectional study of 11 271 patients

“…Atopy is associated with various autoimmune morbidities, similarly CU . IgE sensitization is higher among patients with CU than in the general population, resembling many atopic conditions . Consistently with this, previous epidemiological observations reported an association between CU and atopy .…”

“…Consistently with this, previous epidemiological observations reported an association between CU and atopy . On the other hand, other opposing epidemiological studies reported no such association . Nevertheless, these inconsistent epidemiological studies were mostly limited by relying on small series and restricted paediatric populations, or applied nonvalidated questionnaires.…”

Basophil CD63 expression in chronic spontaneous urticaria: correlation with allergic sensitization, serum autoreactivity and basophil reactivity

“…The allergic sensitization in chronic urticaria patients has been found to be higher than that in healthy subjects. 12,13,18,19 However, the significance of allergic sensitization in the pathogenesis of CSU is still a matter of debate, 13,[18][19][20] and there has been no experimental study to directly address this question. In line with the findings of Vasagar et al, our results also showed a significant increase in CD63 expression on the surface of circulating basophils in both the CSU and atopic groups.…”

Evaluation of Autologous Serum Skin Test and Skin Prick Test Reactivity to House Dust Mite in Patients with Chronic Spontaneous Urticaria

“…However, the significance of mite sensitization in the pathogenesis of CSU is still in dispute [13], [14], [15], [17], [18], [19], [25]. Theoretically, it is possible that HDM induce urticarial reactions via entering the body through inhalation or through the epidermis [20], [26].…”