Basophil CD63 expression in chronic spontaneous urticaria: correlation with allergic sensitization, serum autoreactivity and basophil reactivity

Abstract

The increased CD63 expression in basophils from CSU patients may correlate with allergen sensitization, autoreactivity of serum and basophil reactivity. Our results suggest that CD63 may contribute new insight into the pathogenesis of CSU.

Natural course and prognostic factors of chronic urticaria in Korean children: A single center experience

“…26 Furthermore, higher expression of CD63 was observed in basophils from patients with CSU, suggesting that spontaneous basophil activation may contribute to the relationship between CU and allergic sensitization. 29 The presence of inducible factors and/or autoimmune antibodies have been considered poor prognostic factors in previous studies of patients with CU, although this is still controversial. 15,22,23 We found a trend for an association between the presence of inducible factors and remission without statistical significance in the multivariable analysis.…”

Different expression patterns of plasma Th1‐, Th2‐, Th17‐ and Th22‐related cytokines correlate with serum autoreactivity and allergen sensitivity in chronic spontaneous urticaria

“…21,22 The allergens of SPT included the house dust mites Dermatophagoides farinae and Dermatophagoides pteronyssinus, cockroach allergen, mugwort pollen, humulus pollen, fish (catfish), shrimp, crab, egg, cow milk and peanut. 21,22 The allergens of SPT included the house dust mites Dermatophagoides farinae and Dermatophagoides pteronyssinus, cockroach allergen, mugwort pollen, humulus pollen, fish (catfish), shrimp, crab, egg, cow milk and peanut.…”

“…10 A complex network of cytokines released by the Th cells is involved in various autoimmune and allergic responses. 15 IL-22 is synthesized and released by Th22, and both IL- 22 and Th22 have been confirmed to play important roles in atopic diseases. 12 The imbalance between Th1 and Th2 has long been considered as a possible mechanism in urticaria.…”

“…15 IL-22 is synthesized and released by Th22, and both IL- 22 and Th22 have been confirmed to play important roles in atopic diseases. 22 This study was aimed to analyse the association of distinct responses with ASST and/or SPT in CSU patients with different immune status and cytokine profile. Skin prick test (SPT) can provide useful evidence of allergen sensitivity.…”

“…13,14 Th17 cells, which produce IL-17, IL-17F, IL-21, transforming growth factor (TGF)-b and IL-23, are thought to contribute to autoimmune and allergic diseases. 15 IL-22 is synthesized and released by Th22, and both IL- 22 and Th22 have been confirmed to play important roles in atopic diseases. 16 Autologous serum skin test (ASST) is a simple and effective procedure to test serum autoreactivity in patients with CSU.…”