Chronic sialadenitis with pleomorphic adenoma of the parotid: coincidental or causal?

Ratan, Simmi K.; Bhardwaj, Mukesh; Gambhir, Ajay; Sen, Arya

doi:10.1007/s003830200013

Cited by 3 publications

(2 citation statements)

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“…Two cases of chronic nongranulomatous sialadenitis alongside salivary pleomorphic adenomas have been reported, the authors suggesting that chronic sialadenitis may result in progressive sialectasis (with stasis and acinar destruction), and that this inflammation later leads to development of neoplasia. 4,5 A recent histological study of 40 major and minor salivary glands identified areas of inflammation in the peritumoral area, pseudocapsule, and in the connective tissue stroma in 95% of the examined specimens. 6…”

Section: Discussionmentioning

confidence: 99%

Chronic Granulomatous Dacryoadenitis Associated With Pleomorphic Adenoma

Vahdani

Luthert

Rose

2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Chronic granulomatous inflammation occurs rarely alongside pleomorphic adenomas of the major salivary glands but would not appear to have been reported with lacrimal gland adenomas. We describe the clinical features, imaging and histopathology for 4 patients (3 female) who had granulomatous inflammation alongside lacrimal gland adenomas—the patients being with age 39, 44, 48, and 53 years at time of surgery. One patient had an asymptomatic lesion found on imaging, and the other 3 had symptoms for between 3 years and several decades. Conjecturally, this rare phenomenon might arise from an inflammatory response to leakage of secretions from the ductular components of the glands.

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Section: Discussionmentioning

confidence: 99%

Chronic Granulomatous Dacryoadenitis Associated With Pleomorphic Adenoma

Vahdani

Luthert

Rose

2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…It is possible that the long standing presence of a Warthin tumor may give rise to chronic obstructive sialadenitis in the surrounding gland. [21][22][23] Long standing chronic sialadenitis can give rise to ductal metaplasia, then dysplasia, followed by carcinoma. 24,25 Warthin tumor is boggy on physical examination because of fluid filled cystic spaces.…”

Section: Synchronous Ipsilateral Warthin Tumormentioning

confidence: 99%

Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: A case report and review of the literature

Srivastava

Nadelman

2009

Diagnostic Cytopathology

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Fine-needle aspiration (FNA) is a cost effective and low morbidity procedure in the initial assessment of salivary gland tumors. However, cytological assessment of ipsilateral synchronous tumors (which make up less than 0.3% of all salivary gland neoplasms) may pose diagnostic challenges. Therefore, a wholesome approach, including FNA with clinical and radiological correlation, is of utmost importance. Here, we report a unique case of Warthin tumor encased by a separate high-grade mucoepidermoid carcinoma that was first diagnosed on FNA. Another striking feature seen was the presence of chronic sialadenitis in the surrounding nonneoplastic salivary gland. The presence of two different neoplasms in the background of chronic sialadenitis raises the question of a possible causal relationship. Traditionally, there has been diagnostic difficulty when dealing with synchronous tumors of the salivary gland and the background of chronic sialadenitis may further complicate the diagnosis. FNA is very helpful and can give important cues to the diagnosis.

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