Chronic restraint stress alters rat behavior depending on sex and duration of stress

Pansarim, Vítor; Leite-Panissi, Christie R.A.; Schmidt, Andréia

doi:10.1016/j.beproc.2023.104856

Cited by 2 publications

(2 citation statements)

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“…CRS refers to a restraint stimulus that is repeated at regular consecutive intervals. In the elevated plus‐maze (EPM) test, males exposed to CRS for 11 days showed higher anxiety‐related behaviors than males exposed to CRS for 22 days, but the same behavior was not observed in females 22 . Meanwhile, chronic stress impairs hippocampal function as evidenced by poor spatial ability in male rats but not in females 23 .…”

Section: Current Animal Models Of Anxietymentioning

confidence: 99%

“…In the elevated plus‐maze (EPM) test, males exposed to CRS for 11 days showed higher anxiety‐related behaviors than males exposed to CRS for 22 days, but the same behavior was not observed in females. 22 Meanwhile, chronic stress impairs hippocampal function as evidenced by poor spatial ability in male rats but not in females. 23 It is possible that females are more resistant to the harmful effects of restraint stress on anxiety.…”

Section: Current Animal Models Of Anxietymentioning

confidence: 99%

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Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms

Zhao,

Zhou,

Liu

et al. 2023

Anim Models and Exp Med

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Anxiety disorders have become one of the most severe psychiatric disorders, and the incidence is increasing every year. They impose an extraordinary personal and socioeconomic burden. Anxiety disorders are influenced by multiple complex and interacting genetic, psychological, social, and environmental factors, which contribute to disruption or imbalance in homeostasis and eventually cause pathologic anxiety. The selection of a suitable animal model is important for the exploration of disease etiology and pathophysiology, and the development of new drugs. Therefore, a more comprehensive understanding of the advantages and limitations of existing animal models of anxiety disorders is helpful to further study the underlying pathological mechanisms of the disease. This review summarizes animal models and the pathogenesis of anxiety disorders, and discusses the current research status to provide insights for further study of anxiety disorders.

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Section: Current Animal Models Of Anxietymentioning

confidence: 99%

Section: Current Animal Models Of Anxietymentioning

confidence: 99%