Chronic renal destruction and parathyroid hyperplasia

Magnus, Hugo; Scott, Ronald Bodley

doi:10.1002/path.1700420312

Cited by 14 publications

(2 citation statements)

References 12 publications

(2 reference statements)

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“…Skin biopsies of affected areas fail to show granulomatous inflammation or fibri noid necrosis, demonstrating instead, when appropriately stained, medial calcinosis usually accompanied by inti mai proliferation and ischemic epidermolysis [2,5,15,[20][21][22]24], Stains for immunoglobulins and complement arc also negative [2], The peripheral gangrene frequently leads to surgical amputation of one or more extremities, or, in lesions of terminal phalanges, to eschar formation, demarcation and eventually self-amputation. In addition to acral gangrene and ischemic necrosis of skin and sub cutaneous fat tissue, the most characteristic clinical man ifestations, myopathy, fever, hypotension, dementia, and central nervous system dysfunction, cerebral, myocardial and bowel infarction have also been described [8,22,26,33]. The course of the disease is frequently rapidly pro gressive and sepsis, resulting from secondary infection of skin lesions, refractory hypotension and cerebrovascular accidents arc the leading causes of death.…”

Section: Discussionmentioning

confidence: 99%

Systemic Calciphylaxis Revisited

Adrogué¹,

Frazier

Zeluff³

et al. 1981

Am J Nephrol

103

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A syndrome characterized by rapidly progressive ischemic necrosis involving large areas of the skin and muscle, and by peripheral gangrene associated with extensive vascular calcifications was observed in a patient with end-stage renal failure on chronic hemodialysis. In an effort to control the disease, parathyroidectomy was performed which resulted in rapid improvement of tissue perfusion. However, the patient eventually died from sepsis within 2 months after admission. This case presents the typical features of the syndrome of systemic calciphylaxis. The literature is reviewed searching for similar cases of this poorly recognized, but life-threatening, clinical syndrome. The pathogenesis, clinical manifestations, and therapy of this unusual and rapidly progressive, but potentially reversible, condition are reviewed with emphasis on its prompt recognition and appropriate management.

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Section: Discussionmentioning

confidence: 99%

Systemic Calciphylaxis Revisited

Adrogué¹,

Frazier

Zeluff³

et al. 1981

Am J Nephrol

103

View full text Add to dashboard Cite

show abstract

“…1. MacCallum (1), Bergstrand (2), Hubbard and Wentworth (3), Pollack and Siegal (4), Magnus and Scott (5), have demonstrated the occurrence of parathyroid hyperplasia in individual cases of chronic nephritis. Pappenheimer and Wilens (6) have shown that such enlargement occurs regularly, and is proportional to the degree of renal damage.…”

mentioning

confidence: 99%