The Effect of Experimental Reduction of Kidney Substance Upon the Parathyroid Glands and Skeletal Tissue

Abstract

There are many established facts pointing to a relationship between kidneys and parathyroids.

The Calcium Content of the Kidney as Related to Parathyroid Function

“…Having found that partial nephrectomy leads to a definite increase in the calcium of the remaining kidney tissue, it was of interest to It must be pointed out that the figures for parathyroid volume of normal rats are lower than those reported in previous papers (4,5). The reason for this discrepancy has not been discovered.…”

“…Enlargement of the parathyroid glands is of regular occurrence in human cases of chronic renal disease (1)(2)(3), and may be experimentally induced in rats by reduction of functional kidney tissue (4,5). This enlargement is attended by an increase in circulating parathormone (6).…”

Bright's Disease

“…26 reports that in young rats a reduction in amount of renal tissue regularly results in an increase in size of the parathyroid glands. In the course of a study of the vascular and parenchymal changes in the arteriosclerotic kidney Loomis 2i found adaptive changes in the vessels of Ludwig which bring them into great prominence as compared with their inconspicuousness in the normal kidney.…”

Proceedings: Pathogenesis and Treatment of Renal Osteodystrophy

“…Bone abnormalities have been known to be associated with chronic kidney disease for more than 60 years [1,2]. Renal osteodystrophy is the term used to describe the many different patterns of the skeletal abnormalities that occur in patients with chronic kidney disease.…”