Chronic recurrent multifocal osteomyelitis: spinal involvement and radiological appearances

Martin, J. C.; Desoysa, R.; O’Sullivan, Margaret; Sdlverstone, E.; Williams, Heather

doi:10.1093/rheumatology/35.10.1019

Cited by 35 publications

(25 citation statements)

References 5 publications

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“…King et al [6] described 3 diagnostic criteria that need to be fulfilled: multifocal (у2) bone lesions; a prolonged course (16 months) with patients remaining healthy between acute episodes of pain; and lack of response to antibiotic therapy for у1 month. CRMO most commonly affects the metaphyseal regions of long bones, such as the distal tibia, femur, and clavicle, as well as the mandible and spine [7]. Radiographic findings are often suggestive of osteomyelitis, but the diagnosis of CRMO is usually confirmed by isotope bone scanning and MRI.…”

Section: Patientmentioning

confidence: 99%

“…A 99mTc bone scan commonly reveals multiple, often asymptomatic, foci of high uptake, and MRI shows lytic lesions surrounded by sclerotic areas and variable amounts of bone and soft tissue edema. MRI is the most sensitive method of determining the extent of bony and spinal involvement [7]. It has been suggested that typical MRI features can distinguish bacterial osteomyelitis from CRMO [8], although biopsy remains essential to exclude infections or tumors, such as Ewing's sarcoma.…”

Section: Patientmentioning

confidence: 99%

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Chronic Recurrent Multifocal Osteomyelitis: Two Cases of Sacral Disease Responsive to Corticosteroids

Holden

David

2005

Clinical Infectious Diseases

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Chronic recurrent multifocal osteomyelitis is a rare inflammatory form of osteomyelitis of unknown etiology. It affects children and adolescents, and signs and symptoms include recurrent episodes of bone pain, tenderness, possible constitutional upset, and increased inflammatory markers. We present 2 patients with cases of chronic recurrent multifocal osteomyelitis affecting the sacrum who responded dramatically to treatment with corticosteroids.

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Section: Patientmentioning

confidence: 99%

Section: Patientmentioning

confidence: 99%

Chronic Recurrent Multifocal Osteomyelitis: Two Cases of Sacral Disease Responsive to Corticosteroids

Holden

David

2005

Clinical Infectious Diseases

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“…Although bone scintigraphy is an excellent tool for identifying symptomatic sites as well as clinically silent lesions, a few authors have reported slightly reduced sensitivity of the technique compared with MRI in the evaluation of spinal, pelvic, and femoral lesions [8,26,27]. Morbach et al [27] compared whole-body bone scintigraphy with MRI in 32 patients by performing wholebody MRI in 14 patients and localized MRI in the other 18 patients.…”

Section: Imaging Findingsmentioning

confidence: 99%

Chronic recurrent multifocal osteomyelitis

Acikgoz

Averill

2014

Nuclear Medicine Communications

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Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease of unknown etiology. It affects children and adolescents predominantly and occurs mostly in the female population. It is characterized by the insidious onset of pain and swelling, with a fluctuating clinical course of relapses and remissions. Typically, several bones are affected, either synchronously or metachronously, and bilateral involvement is common. CRMO most commonly affects the metaphysis of long bones, especially the tibia, femur, and clavicle. The spine, pelvis, ribs, sternum, and mandible may also be affected. Although lesions are mostly multiple, patients may present with a single symptomatic focus. Radiographic findings may be negative early in the course of the disease. Bone scintigraphy is useful in determining the presence of abnormality and the extent of disease. The imaging and clinical features of CRMO overlap with those of infectious osteomyelitis, bone malignancy, and inflammatory arthritis. Nonetheless, CRMO can be confidently diagnosed with the recognition of typical imaging patterns in the appropriate clinical setting. This article reviews imaging findings with special emphasis on bone scintigraphy and specific disease sites.

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“…MRI has been reported to be more specific and sensitive than plain radiography or isotope bone scan also in defining the extent of spinal lesions (Martin, Desoysa et al 1996). Recently, whole body evaluation by MRI has been used to characterize all active CNO lesions at disease onset, and to systematically evaluate radiological treatment response (Beck, Morbach et al 2010).…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Chronic Non-Bacterial Osteitis/Chronic Recurrent Multifocal Osteomyelitis

Miettunen¹

2012

Osteomyelitis

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Chronic recurrent multifocal osteomyelitis: spinal involvement and radiological appearances

Cited by 35 publications

References 5 publications

Chronic Recurrent Multifocal Osteomyelitis: Two Cases of Sacral Disease Responsive to Corticosteroids

Chronic Recurrent Multifocal Osteomyelitis: Two Cases of Sacral Disease Responsive to Corticosteroids

Chronic recurrent multifocal osteomyelitis

Chronic Non-Bacterial Osteitis/Chronic Recurrent Multifocal Osteomyelitis

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