Chronic recurrent multifocal osteomyelitis

Acikgoz, Gunsel; Averill, Lauren W.

doi:10.1097/mnm.0000000000000126

Cited by 37 publications

(14 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pathogenesis and etiology of this condition is currently unknown [13,14]. Some reports suggest an infectious origin; suspected organisms include Staphyloccocus aureus, Mycoplasma hominis, Propionibacterium acnes and Chlamydia [15–17].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic recurrent multifocal osteomyelitis - case report of two patients and review of literature

Schwarzkopf

Agaram

et al. 2019

Int. J. Clin. Rheumatol

View full text Add to dashboard Cite

Background Chronic Recurrent Multifocal Osteomyelitis (CRMO) is an autoinflammatory skeletal disease characterized by unifocal or multifocal nonbacterial inflammatory bone lesions in the metaphysis of long bones. Common sites of CRMO are tibia, pelvis, proximal femur, clavicle, calcaneum and vertebrae. However, unifocal presentation or presentation in adults, atypical locations, and absence of recurrence have also been reported. Methods and Findings We describe two cases of female patients with unifocal presentation of nonbacterial inflammatory bone lesions in the upper and lower extremity. Furthermore, a review of literature is presented. Conclusion Although CRMO is seen primarily in children and adolescents, and usually occurs in a multifocal pattern, our cases illustrate that this disease can arise in adult patients and in a single location. The diagnosis of CRMO should be made in a multi-disciplinary approach amongst orthopedic surgeons, radiologists and pathologists.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Typically, patients present with unspecific complaints including pain, tenderness, swelling or limited range of motion [6]. The lesions can be unifocal or multifocal, bilateral involvement is common [1,13]. The mean age at onset of symptoms is 10 years [26,27], but it has been reported in older patients up to the age of 55 years [16,19].…”

Section: Discussionmentioning

confidence: 99%

Chronic recurrent multifocal osteomyelitis - case report of two patients and review of literature

Schwarzkopf

Agaram

et al. 2019

Int. J. Clin. Rheumatol

View full text Add to dashboard Cite

show abstract

“…This association has not previously been reported. While clavicular involvement in CRMO may be seen in up to 25% of cases, most lesions start medially and spare the sternoclavicular joint [62]. The aggressive appearance and soft tissue inflammation in this case, as well as involvement of the sternoclavicular joint raised concerns for a malignant process.…”

Section: Discussionmentioning

confidence: 99%

Retinal vasculitis with Chronic Recurrent Multifocal Osteomyelitis: a case report and review of the literature

et al. 2019

View full text Add to dashboard Cite

Background Concurrent presentation of retinal vasculitis with mixed sclerotic and lytic bone lesions is rare. Case presentation We present the case of a 37-year old woman with a several year history of episodic sternoclavicular pain who presented for rheumatologic evaluation due to a recent diagnosis of retinal vasculitis. We review the differential diagnosis of retinal vasculitis, along with the differential diagnosis of mixed sclerotic and lytic bone lesions. Ultimately, bone marrow biopsy confirmed diagnosis of chronic recurrent multifocal osteomyelitis (CRMO). Concurrent presentation of CRMO with retinal vasculitis is extremely rare but important to recognize. The patient demonstrated clinical response to prednisone and tumor necrosis factor-alpha inhibition (TNF-i). Conclusion This case reports and unusual presentation of CRMO spectrum disease involving the sternum and sternoclavicular joint with concurrent retinal vasculitis.

show abstract

“…Symptoms of CRMO might be varied - from asymptomatic single-bone involvement to chronic, recurrent, multifocal inflammation with systemic symptoms such as weakness, febrile states and weight loss [2]. Bone lesions are located in various skeletal sites, mainly in long bones metaphyses (tibia, thigh, arrow), pelvic bones, spine, clavicle or mandible [3]. A diagnostic path is complicated and includes laboratory tests and variation of imaging examinations.…”

Section: Introductionmentioning

confidence: 99%

A complicated path to the CRMO diagnosis – case of a 9 year old girl whose story comes full circle

Świdrowska-Jaros

Smolewska

2019

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background Chronic recurrent multifocal osteomyelitis (CRMO) is a rare idiopathic autoinflammatory bone disease that mostly affects children and adolescents. It is a diagnosis of exclusions since no clinical signs and symptoms are pathognomonic. Radiological tests are often essential, but bone biopsy may be needed in unclear cases. Case presentation A 9-year-old Caucasian girl with a history of bone pain. The data from the history and results of laboratory tests suggested osteomyelitis, but no adequate response to the treatment was observed. A number of imaging tests did not confirm the diagnosis, therefore a bone biopsy was necessary. Conclusions Differential diagnosis of CRMO is challenging and it is based on exclusions. Since it might be misdiagnosed or mistreated, bone biopsy should be considered in patients reporting bone pain who are unresponsive to treatment.

show abstract

Chronic recurrent multifocal osteomyelitis

Cited by 37 publications

References 29 publications

Chronic recurrent multifocal osteomyelitis - case report of two patients and review of literature

Chronic recurrent multifocal osteomyelitis - case report of two patients and review of literature

Retinal vasculitis with Chronic Recurrent Multifocal Osteomyelitis: a case report and review of the literature

A complicated path to the CRMO diagnosis – case of a 9 year old girl whose story comes full circle

Contact Info

Product

Resources

About