Chronic polyneuritis of childhood

Tasker, William; Chutorian, Abe M.

doi:10.1016/s0022-3476(69)80132-0

Cited by 21 publications

(5 citation statements)

References 19 publications

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“…The fact that the diagnosis of this disease may be missed when it presents as a pure peripheral neuropathy is also illustrated by the present cases and by a recent paper on chronic polyneuritis of childhood (Tasker and Chutorian, 1969). Out of 17 cases that are described in that paper no aetiology could be defined in 15, one was found to be due to metachromatic leucodystrophy, and one to Dejerine-Sottas disease.…”

Section: Discussionsupporting

confidence: 50%

“…Although it is known that the peripheral nerves share in the pathological changes that occur in metachromatic leucodystrophy (Greenfield, 1933;Brain and Greenfield, 1950;Thieffry and Lyon, 1959;Hagberg, Sourander, and Thoren, 1962;Webster, 1962) and that these changes may manifest themselves clinically (Hagberg et al, 1962;Hagberg, 1963;Fullerton, 1964), it is not well recognized that peripheral neuropathy may sometimes be the presenting feature of this disease (Yuddell, Gomez, Lambert, and Dockerty, 1967;Tasker and Chutorian, 1969). The purpose of this paper is to report two such patients, seen in one regional unit over the four year period, 1967-71, who presented purely as cases of peripheral neuropathy.…”

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confidence: 99%

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Neuropathy of metachromatic leucodystrophy

Silva

Pearce

1973

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY We describe two patients with metachromatic leucodystrophy who presented with peripheral neuropathy and had no evidence of central nervous system involvement at the time of presentation. Such an occurrence is not well recognized and the diagnosis is usually missed until the other features of the disease manifest themselves. Early recognition of this disease may become of practical importance from the point of view of therapy, judging from recent developments, and is also important from the point of view of genetic counselling. We suggest that cases of peripheral neuropathy in infancy and childhood, should be subjected to peripheral nerve biopsy when the aetiology is not obvious.Although it is known that the peripheral nerves share in the pathological changes that occur in metachromatic leucodystrophy (

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Section: Discussionsupporting

confidence: 50%

mentioning

confidence: 99%

Neuropathy of metachromatic leucodystrophy

Silva

Pearce

1973

Journal of Neurology, Neurosurgery & Psychiatry

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“…The cerebrospinal fluid was not considered specific and the familial component was also rejected in the light of the clinical exploration and electromyographic results performed. On the other hand, it has been said (Tasker and Chutorian, 1969) that a great deal of chronic polyneuritis in infancy remains without defined aetiology. During her stay in hospital the patient showed an evolution towards hypertonus in lower extremities which, together with the change in character, were the symptoms that led us to establish the possibility of leucodystrophy, which was confirmed by the nerve biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…Polyneuropathy in metachromatic leucodystrophy, even at an early stage is now familiar and in recent years has received increasing interest (Yudell et al, 1967;Aziz and Pearce, 1968;Gamstorp, 1968Gamstorp, , 1970Tasker and Chutorian, 1969;De Silva and Pearce, 1973). The electrophysiological study is usually the first test to confirm the polyneuritis, and is therefore of great orientation value.…”

Section: Discussionmentioning

confidence: 99%

Peripheral neuropathy detected on electrophysiological study as first manifestation of metachromatic leucodystrophy in infancy.

Martínez¹,

Ferrer²,

Fueyo³

et al. 1975

Journal of Neurology, Neurosurgery & Psychiatry

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SYNOPSIS A case of infantile metachromatic leucodystrophy is described in which symptoms started at 1 year of age with weakness and hypotonus in the lower extremities. The electrophysiological status was typical of a polyneuropathy, showing fibrillation and a reduction of the nerve conduction velocity to 30%. of the average for normal children of the same age. Clinical signs of a central lesion and mental regression were not evident until a year later. Nerve biopsy showed metachromatic granules in the phagocytes and in the Schwann cells, confirming the diagnosis of metachromatic leucodystrophy. In peripheral neuropathy in infancy without obvious cause, a nerve biopsy is the most appropriate method for diagnosis of the metachromatic leucodystrophy.

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“…Women are more likely to enter a chronic phase than men. In children Guillain-Barre syndrome is often atypical, and may have a chronic course without a typical subacute onset, and without relapse (Tasker & Chutorian 1969). Cases with central manifestations In a few patients there are signs of involvement of the central nervous system.…”

Section: Relapsing Inflammatory Polyradiculoneuropathymentioning

confidence: 99%

Clinical Aspects of Guillain-Barré Syndrome: A Review

Swash

1979

J R Soc Med

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and Strohl published an account of two soldiers, whose nonfatal ascending paralytic illness was similar in many respects to that described in numerous previous publications (see Haymaker & Kernohan 1949), there was already an extensive literature of cases of ascending flaccid paralysis with sensory symptoms. Landry (1859) reviewed 10 patients with a fatal form of ascending paralysis, some with facial paralysis, but Guillain and his colleagues did not accept these as examples of polyradiculoneuritis because oftheir fatal outcome (Guillain et al. 1916, Guillain 1936a). Guillain (1936a, b) was particularly strict in his definition of the syndrome; for example, he preferred to exclude all cases with a fatal outcome, with a febrile onset, with central manifestations, and with a cerebrospinal fluid

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Chronic polyneuritis of childhood

Cited by 21 publications

References 19 publications

Neuropathy of metachromatic leucodystrophy

Neuropathy of metachromatic leucodystrophy

Peripheral neuropathy detected on electrophysiological study as first manifestation of metachromatic leucodystrophy in infancy.

Clinical Aspects of Guillain-Barré Syndrome: A Review

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