Chronic pesticides exposure on the farmers in Tanjung Wangi Village: Focus on Alpha-Synuclein as a Biomarker of Parkinson-sporadic

Abstract

The study aim was to analyze the effect of chronic pesticide exposure on farmers in Tanjung Wangi village. Observational study with male adult farmer as respondents. 100 questionnaires were given to farmers and 56 returned. The average age of respondents was 46.5 years, education was primary school, length of work/day was 4-6 hours, length as farmer was more than 10 years. The results were no respondents have Parkinson symptoms with a median score were 57, 61, and 67.5 on 1 to 5, 5 to10, and more than 10 years pesticide exposure respectively. From 56 respondents selected 30 persons randomly for physical examination (PE) and blood examination Parameters measured were PE, concentration of glutathione-total and alpha-synuclein in erythrocyte membranes. Data analysis was performed with IBM SPSS 21. The results were no respondents have digestive and balance disorders. Alpha-synuclein concentrations were not significantly different between the length of exposure as well as total glutathione concentrations. PE significant correlation with alpha-synuclein (rho=0.366, p=0.044). Pesticides cause oxidative stress in erythrocytes. Alpha-synuclein has the potential as a biomarker for Parkinson-sporadic disease.