Chronic persistent cough in the community: a questionnaire survey

Everett, Caroline F.; Kastelik, Jack A.; Thompson, Rachel H.; Morice, Alyn H.

doi:10.1186/1745-9974-3-5

Cited by 98 publications

(113 citation statements)

References 14 publications

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“…Everett et al [19] also found that chronic cough was associated with a significant adverse impact on physical, psychological and social wellbeing of subjects. The strength of our study in contrast to Everett et al [19] participants with chronic cough registered with a research company via e-mail. The recruitment of volunteers from a research company database is likely to have introduced a selection bias.…”

Section: Discussionmentioning

confidence: 96%

“…Few surveys have specifically assessed the impact of chronic cough in detail. Everett et al [19] surveyed 373 subjects with chronic cough in the community based in the UK that responded initially to a radio broadcast. Everett et al [19] also found that chronic cough was associated with a significant adverse impact on physical, psychological and social wellbeing of subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Everett et al [19] surveyed 373 subjects with chronic cough in the community based in the UK that responded initially to a radio broadcast. Everett et al [19] also found that chronic cough was associated with a significant adverse impact on physical, psychological and social wellbeing of subjects. The strength of our study in contrast to Everett et al [19] participants with chronic cough registered with a research company via e-mail.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Impact of Chronic Cough: A Cross-Sectional European Survey

Chamberlain

Garrod

Douiri

et al. 2015

Lung

198

193

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of Chronic Cough: A Cross-Sectional European Survey

Chamberlain

Garrod

Douiri

et al. 2015

Lung

198

193

View full text Add to dashboard Cite

“…A UK postal survey found that the majority of people reporting cough were distressed, angry, anxious and depressed, and 64% felt the cough interfered with their social and family life [97,98]. However, the relationship between health status and cough reflex sensitivity, as defined by inhalational challenge, is weak.…”

Section: Cough In Other Diseasesmentioning

confidence: 99%

“…For patients, having a diagnosis of CHS and realising that there is a pathophysiological basis for their symptoms is of considerable benefit. Removing the ''nothing is wrong with them'' response improves psychological well-being and quality of life [97].…”

Section: Cough In Other Diseasesmentioning

confidence: 99%

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

et al. 2014

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In 2011, a European Respiratory Society Task Force embarked on a process to determine the position and clinical relevance of the cough hypersensitivity syndrome, a disorder characterised by troublesome coughing often triggered by low levels of thermal, mechanical or chemical exposure, in the management of patients with chronic cough. A 21-component questionnaire was developed by an iterative process supported by a literature review. 44 key opinion leaders in respiratory medicine were selected and interviewed as to their opinions.There was a high degree of unanimity in the responses obtained, with all opinion leaders supporting the concept of cough hypersensitivity as a clinically useful paradigm. The classic stratification of cough into asthmatic, rhinitic and reflux-related phenotypes was supported. Significant disparity of opinion was seen in the response to two questions concerning the therapy of chronic cough. First, the role of acid suppression in reflux cough was questioned. Secondly, the opinion leaders were split as to whether a trial of oral steroids was indicated to establish a diagnosis of eosinophilic cough.The cough hypersensitivity syndrome was clearly endorsed by the opinion leaders as a valid and useful concept. They considered that support of patients with chronic cough was inadequate and the Task Force recommends that further work is urgently required in this neglected area. @ERSpublications Cough hypersensitivity syndrome was clearly endorsed by opinion leaders as a valid and useful concept

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From bench to bedside: The role of cough hypersensitivity in chronic cough

Drake

McGarvey

Morice

2023

Clinical & Translational Med

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BackgroundChronic cough is a burdensome condition characterized by persistent cough lasting longer than 8 weeks. Chronic cough can significantly affect quality of life, physical function and productivity, with many people troubled with a cough that lasts for months or even years. People with chronic cough commonly report a persistent urge to cough with frequent bouts of coughing triggered by innocuous stimuli, which has led to the concept of cough hypersensitivity.Main bodyBoth central and peripheral neural pathways regulate cough, and although mechanisms driving development of cough hypersensitivity are not fully known, sensitization of these neural pathways contributes to excessive cough triggering in cough hypersensitivity. Effective therapies that control chronic cough are currently lacking. Recent therapeutic development has focused on several ion channels and receptors involved in peripheral activation of cough (e.g., transient receptor potential channels, P2 × 3 receptors and voltage‐gated sodium channels) or central cough processing (e.g., neurokinin‐1 [NK‐1] receptors and nicotinic acetylcholine receptors).ConclusionThese targeted therapies provide novel insights into mechanisms underlying cough hypersensitivity and may offer new treatment options for people with chronic cough. In this review, we explore preclinical and clinical studies that have improved our understanding of the mechanisms responsible for chronic cough and discuss the most promising targeted approaches to date, including trials of P2 × 3‐receptor antagonists and NK‐1–receptor antagonists.

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Chronic persistent cough in the community: a questionnaire survey

Cited by 98 publications

References 14 publications

The Impact of Chronic Cough: A Cross-Sectional European Survey

The Impact of Chronic Cough: A Cross-Sectional European Survey

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

From bench to bedside: The role of cough hypersensitivity in chronic cough

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