The Impact of Chronic Cough: A Cross-Sectional European Survey

In 2011, a European Respiratory Society Task Force embarked on a process to determine the position and clinical relevance of the cough hypersensitivity syndrome, a disorder characterised by troublesome coughing often triggered by low levels of thermal, mechanical or chemical exposure, in the management of patients with chronic cough. A 21-component questionnaire was developed by an iterative process supported by a literature review. 44 key opinion leaders in respiratory medicine were selected and interviewed as to their opinions.There was a high degree of unanimity in the responses obtained, with all opinion leaders supporting the concept of cough hypersensitivity as a clinically useful paradigm. The classic stratification of cough into asthmatic, rhinitic and reflux-related phenotypes was supported. Significant disparity of opinion was seen in the response to two questions concerning the therapy of chronic cough. First, the role of acid suppression in reflux cough was questioned. Secondly, the opinion leaders were split as to whether a trial of oral steroids was indicated to establish a diagnosis of eosinophilic cough.The cough hypersensitivity syndrome was clearly endorsed by the opinion leaders as a valid and useful concept. They considered that support of patients with chronic cough was inadequate and the Task Force recommends that further work is urgently required in this neglected area. @ERSpublications Cough hypersensitivity syndrome was clearly endorsed by opinion leaders as a valid and useful concept

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“…81% reported a limitation of activities they would like to do. 91% felt fed up or depressed because of their cough [100].…”

Section: Cough Engagement Question 21mentioning

confidence: 99%

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

et al. 2014

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“…There is some controversy if these conditions are aggravants or causes of cough. What is more, many people have a cough reflex sensitivity and their cough cannot be expalined [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…What is more, people are more depressed, feel anxienty or social embarrassment of their cough. It can dissturb not only work and activity but also family members and friends [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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AbstractBackground: Cough is the most common presenting symptom in primary practice.[1] Chronic, exhausted cough has a significant impact on the quality of life [2]. Cough questionnaire was developed to evaluate the quality of life for patients with chronic cough.

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confidence: 99%

“…There is some controversy if these conditions are aggravants or causes of cough. What is more, many people have a cough reflex sensitivity and their cough cannot be expalined [2,3].Patients with chronic cough suffer physical and psychological morbidity. Long lasting chronic cough can affect the quality of life interfering with physical symptoms as chest pain, syncope, incontinence, sore throat and headaches.…”

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confidence: 99%

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Reliability and Validity of a Lithuanian version of Leicester Cough Questionnaire

Merkyte¹,

Biekšienė²,

Vaguliene³

et al. 2016

JLPRR

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Background: Cough is the most common presenting symptom in primary practice.[1] Chronic, exhausted cough has a significant impact on the quality of life [2]. Cough questionnaire was developed to evaluate the quality of life for patients with chronic cough. Unfortunatelly, such kind of health status measurement do not exist in Lithuania yet. Methods:The translation of Leicester Cough Questionnaire (LCQ) was made using all methods that are required, following a forward-backward translation procedure. The Questionnaire and Visaul Analogue Scale (VAS) was completed by 53 patients with chronic cough (duration of cough > 8 weeks).The Questionnaire was divided into three domains: physical, psychological and social. To validate LCQ we tested three different aspects, i.e. the concurrent validity, the internal consistency and the repeatability.Results: A strong correlation was established among the domains of the questionnaire and a statistically significant correlation established between the questionnaire and VAS. Cronbach`s alpha coefficients for the internal consistency were from 0,787 to 0,927. The intraclass correlation coefficient (ICC) of the testretest reliability was 0,89 (p<0,0001). Conclusion:The Lithuanian version of Leicester Cough Questionnaire is ready, compatible with original and understandable for patients. Leicester Cough Questionnaire appears to be valid, reliable and highly responsive. BackgroundCough is one of the most common causes of presentation to general practice. Cough that has been persisted longer than three weeks is subacute (three to eight weeks) or chronic (more than eight weeks) About 15 precentages of non smoking people complain about the chronic cough [1].Chronic cough is the most common complain during the visit to a pulmonologist. Cough is described as a protective reflex that removes excessive secretions and inhaled foreign bodies from the respiratory tract. The anatomy of respiratory tract which is plentiful of cough receptors is the reason, that the most frequently causes of chronic cough are upper airway disorders, asthma and gastroesophageal reflux. There is some controversy if these conditions are aggravants or causes of cough. What is more, many people have a cough reflex sensitivity and their cough cannot be expalined [2,3].Patients with chronic cough suffer physical and psychological morbidity. Long lasting chronic cough can affect the quality of life interfering with physical symptoms as chest pain, syncope, incontinence, sore throat and headaches. What is more, people are more depressed, feel anxienty or social embarrassment of their cough. It can dissturb not only work and activity but also family members and friends [2-6].To effectively evaluate the impact of chronic cough on quality of life, it is important to have valid measurement tools. A number of measurment tools including questionnaires, cough diaries, visual analogue scales, electronic recordings, and human counts are available to assess the impact of quality of life for people with chronic cough. However...

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Atypical Activation of Laryngeal Somatosensory-Motor Cortex During Vocalization in People With Unexplained Chronic Cough

Misono,

Xu,

et al. 2023

JAMA Otolaryngol Head Neck Surg

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ImportanceUnexplained chronic cough is common and has substantial negative quality-of-life implications, yet its causes are not well understood. A better understanding of how peripheral and central neural processes contribute to chronic cough is essential for treatment design.ObjectiveTo determine if people with chronic cough exhibit signs of abnormal neural processing over laryngeal sensorimotor cortex during voluntary laryngeal motor activity such as vocalization.Design, Setting, and ParticipantsThis was a cross-sectional study of a convenience sample of participants with chronic cough and healthy participants. Testing was performed in an acoustically and electromagnetically shielded chamber. In a single visit, electroencephalographic (EEG) signals were recorded from participants with chronic cough and healthy participants during voice production. The chronic cough group participants presented with unexplained cough of 8 weeks or longer duration with prior medical evaluation including negative results of chest imaging. None of the participants had a history of any neurologic disease known to impair vocalization or swallowing. Data collection for the healthy control group occurred from February 2 to June 28, 2018, and for the chronic cough group, from November 22, 2021, to June 21, 2022. Data analysis was performed from May 1 to October 30, 2022.ExposureParticipants with or without chronic cough.Main Outcome MeasuresEvent-related spectral perturbation over the laryngeal area of somatosensory-motor cortex from 0 to 30 Hz (ie, θ, α, and β bands) and event-related coherence as a measure of synchronous activity between somatosensory and motor cortical regions.ResultsThe chronic cough group comprised 13 participants with chronic cough (mean [SD] age, 63.5 [7.8] years; 9 women and 4 men) and the control group, 10 healthy age-matched individuals (mean [SD] age, 60.3 [13.9] years; 6 women and 4 men). In the chronic cough group, the typical movement-related desynchronization over somatosensory-motor cortex during vocalization was significantly reduced across θ, α, and β frequency bands when compared with the control group.Conclusions and RelevanceThis cross-sectional study found that the typical movement-related suppression of brain oscillatory activity during vocalization is weak or absent in people with chronic cough. Thus, chronic cough affects sensorimotor cortical activity during the asymptomatic voluntary activation of laryngeal muscles.

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The Impact of Chronic Cough: A Cross-Sectional European Survey

Cited by 209 publications

References 23 publications

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

Reliability and Validity of a Lithuanian version of Leicester Cough Questionnaire

Atypical Activation of Laryngeal Somatosensory-Motor Cortex During Vocalization in People With Unexplained Chronic Cough

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