Chronic Periodontitis and the Risk of Tongue Cancer

Tezal, Miné; Sullivan, Maureen; Reid, Mary E.; Marshall, James R.; Hyland, Andrew; Loree, Thorn R.; Lillis, Cheryl; Hauck, Linda; Wactawski‐Wende, Jean; Scannapieco, Frank A.

doi:10.1001/archotol.133.5.450

Cited by 161 publications

(168 citation statements)

References 15 publications

(17 reference statements)

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“…The pathogenesis of the metastasis of malignant tumors to the gingiva is unclear. Following a comprehensive review of the literature, numerous studies were identified that discussed an association between HCC metastasis in particular and chronic periodontitis (20)(21)(22)(23). The patient in the present study had chronic periodontitis before the gingival tumor was observed.…”

Section: A B C Dmentioning

confidence: 77%

Hepatocellular carcinoma metastasis to the gingival soft tissues: A case report and review of the literature

Gong

Zhang

et al. 2015

Oncology Letters

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Abstract. Metastases to the gingival soft tissues are rare in hepatocellular carcinoma (HCC). To the best of our knowledge, only 13 cases have been reported in English literature to date. The present study described the case of a 43-year-old Chinese man who was admitted to Tangdu Hospital (Xi'an, China) due to the presence of a gingival tumor that was initially diagnosed as granulation tissue by a dental surgeon. Examination of the patient's medical history revealed that a solid mass, measuring 1.5 cm in diameter, was identified in the right lobe of the liver 2 years prior to presentation at the current hospital; however, no biopsy was performed. Thus, the tumor was resected and histological examination resulted in an initial diagnosis of atypical squamous cell carcinoma. However, the histopathological characteristics, immunohistochemical features and serum α-fetoprotein expression levels supported a diagnosis of metastatic HCC. In conclusion, the present case study highlights the difficulties in diagnosing metastatic HCC without a history of primary HCC, and the importance of excluding a diagnosis of metastatic tumor when a lesion is identified in the gingival. Furthermore, it was determined that a final diagnosis of gingival metastasis of HCC predominantly depends on pathological characteristics and immunohistochemical features.

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Section: A B C Dmentioning

confidence: 77%

Hepatocellular carcinoma metastasis to the gingival soft tissues: A case report and review of the literature

Gong

Zhang

et al. 2015

Oncology Letters

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“…The correlation of chronic periodontitis with cancer has already been reported in the oral cavity, especially an association with tongue carcinoma and other epithelial head and neck tumors like oral squamous cell carcinoma [78,79].…”

Section: Cancermentioning

confidence: 85%

Human Defensins: Potential Tools for Clinical Applications

Winter

Wenghoefer

2012

Polymers

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As components of the innate immune system, antimicrobial peptides in the form of human defensins play an important role in host defense by serving as the epithelial layer’s biochemical barrier against local infections. Recent studies have shown these molecules to have far more additional cellular functions besides their antimicrobial activity. Defensins play a role in cell division, attraction and maturation of immune cells, differentiation and reorganization of epithelial tissues, wound healing and tumor suppression. This multitude of function makes human defensins appear to be excellent tools for therapeutic approaches. These antimicrobial peptides may be used directly as a remedy against bacterial and viral infections. Furthermore, the application of human defensins can be used to promote wound healing and epithelial reorganization. In particular, human β-defensins have a strong impact on osteoblast proliferation and differentiation. Human β-defensins have already been applied as a vaccination against HIV-1. Another potentially useful characteristic of defensins is their suitability as diagnostic markers in cancer therapy. In particular, α-defensins have already been used for this purpose. Human α-defensin-3, for example, has been described as a tumor marker for lymphocytes. High gene expression levels of α-defensin-3 and -4 have been detected in benign oral neoplasia, α-defensin-6 is considered to be a tumor marker for colon cancer.

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“…Dental profession can play a major role in controlling the oral neoplasms. It is estimated that between 65% and 75% of patients with oral cancer initially present to a dentist (Tezal et al, 2007). About 50% of those who are diagnosed will die within 5 years of diagnosis.…”

Section: Periodontitis and Cancermentioning

confidence: 99%

“…Epidemiological studies have shown a link between periodontal disease and head and neck squamous cell carcinoma. In a case-control study conducted over a period of 6 years to determine the association between periodontal disease and risk of tongue cancers, it was found that each millimetre of alveolar bone loss was associated with a 5.23-fold increase in the risk of tongue cancer (Tezal et al, 2007). In this study, besides periodontitis, other oral health conditions such as dental caries, tooth loss, restorations, and endodontic treatment were also evaluated and the results showed that periodontitis was the only variable that was significantly associated with oral cancer.…”

Section: Periodontitis and Cancermentioning

confidence: 99%

“…Chronic inflammatory processes are frequently associated with the release of large amounts of cytokines, chemokines, growth factors, and other signals that provide an environment for cell survival, proliferation, migration, angiogenesis, and inhibition of apoptosis. This environment may help epithelial cells to accumulate mutations and drive these mutant epithelial cells to proliferate, migrate, and give them a growth advantage (Tezal et al, 2007). The association between periodontal disease and oral neoplasms is biologically plausible and may be explained by the following mechanisms (Tezal et al, 2007).…”

Section: Indirect Effect Through Inflammationmentioning

confidence: 99%

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