Chronic paradoxical sleep deprivation-induced depression­like behavior, energy metabolism and microbial changes in rats

Ma, Wenting; Song, Jing; Wang, Heran; Shi, Fangyu; Zhou, Nian E.; Jiang, Jiaye; Xu, Ying; Zhang, Lei; Yang, Li; Zhou, Mingmei

doi:10.1016/j.lfs.2019.04.006

Cited by 91 publications

(64 citation statements)

References 91 publications

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“…Some studies have reported that Parabacteroides have immunoregulatory functions. And, greater abundance of the genus Parabacteroides has been found in mice exposed to social stressors and related to abnormalities of depression symptoms and inflammatory cytokines in human . Therefore, we presumed that patients with recurrence enrich the genus Parabacteroides might correlate with behavior impairments.…”

Section: Discussionmentioning

confidence: 96%

Alterations in the human gut microbiome in anti‐N‐methyl‐D‐aspartate receptor encephalitis

Gong

Liu

et al. 2019

Ann Clin Transl Neurol

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Objective To explore the diversity and composition of the fecal microbiota in patients with anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis. Methods We enrolled 10 patients in the acute stage with naïve treatment, seven patients with relapse, 13 patients without relapse in the remission phase, and 12 paired healthy controls. The fecal microbiota in different groups was compared by 16S ribosomal DNA (rDNA) gene pyrosequencing. Results Prominent dysbiosis in the gut microbiome of patients with anti‐NMDAR encephalitis was found. Our primary findings showed that the overall species richness (alpha diversity indexes) of the microbiota was higher in patients than in controls (P < 0.05). Distance‐based community analysis revealed that the microbiota differed substantially within all subgroups of patients and controls (P < 0.05). The relative abundance of species heatmap showed a tendency toward depletion for some commensal genera, such as Prevotella_6, Bifidobacterium, Faecalibacterium, and other short‐chain fatty acid (SCFA)‐producing bacteria. Additionally, our results showed that all subgroups had a distinct bacterial species, with an increase in the genus Fusobacterium in the acute phase group and the genera Streptococcus and Parabacteroides in patients with relapse. However, the genus Bacteroides was very abundant in patients without relapse. Although the findings regarding the Firmicutes/Bacteroidetes (F/B) ratios across the four comparison groups were not statistically significant, the F/B ratio gradually increased in patients from the acute phase group (0.87), to the disease remission group with relapse (1.06), to the group without relapse (1.28), to the healthy group (1.63). Interpretation Patients with anti‐NMDAR encephalitis exhibit a substantial alteration in fecal microbiota composition.

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Section: Discussionmentioning

confidence: 96%

Alterations in the human gut microbiome in anti‐N‐methyl‐D‐aspartate receptor encephalitis

Gong

Liu

et al. 2019

Ann Clin Transl Neurol

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“…Previous studies have been reported that chronic stress could result in the disturbance of gut microbiota and host metabolism, which might contribute to the development of depression 26,27 . Here, we found that the gut microbiota, SCFAs in fecal sample and neurotransmitters in hypothalamus were significantly changed in depressed mice compared to control mice.…”

Section: Discussionmentioning

confidence: 99%

Associations between disordered gut microbiota and changes of neurotransmitters and short-chain fatty acids in depressed mice

et al. 2020

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Mounting evidence suggests that gut microbiota can play an important role in pathophysiology of depression, but its specific molecular mechanisms are still unclear. This study was conducted to explore the associations between changes in neurotransmitters and short-chain fatty acids (SCFAs) and altered gut microbiota in depressed mice. Here, the chronic restraint stress (CRS) model of depression was built. The classical behavioral tests were conducted to assess the depressive-like behaviors of mice. The 16S rRNA gene sequence extracted from fecal samples was used to assess the gut microbial composition. Liquid and gas chromatography mass spectroscopy were used to identify neurotransmitters in hypothalamus and SCFAs in fecal samples, respectively. Finally, 29 differential bacteria taxa between depressed mice and control mice were identified, and the most differentially abundant bacteria taxa were genus Allobaculum and family Ruminococcaceae between the two groups. The acetic acid, propionic acid, pentanoic acid, norepinephrine, 5-HIAA and 5-HT were significantly decreased in depressed mice compared to control mice. Genus Allobaculum was found to be significantly positively correlated with acetic acid and 5-HT. Taken together, these results provided novel microbial and metabolic frameworks for understanding the role of microbiota-gut-brain axis in depression, and suggested new insights to pave the way for novel therapeutic methods.

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“…Furthermore, a study of acute sleep loss (four-hour sleep opportunity) in humans also observed an increase in the F:B ratio, but not a global shift in beta diversity [14]. Recently, a study in rats found marked shifts in the fecal microbiome and urinary metabolites after a seven day severe stress/REM deprivation protocol [90]. Taken with the present results, a link between inadequate sleep and the fecal microbiome appears to be present across species and sleep disruption protocols.…”

Section: Discussionmentioning

confidence: 99%

Repeated sleep disruption in mice leads to persistent shifts in the fecal microbiome and metabolome

et al. 2020

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It has been established in recent years that the gut microbiome plays a role in health and disease, potentially via alterations in metabolites that influence host physiology. Although sleep disruption and gut dysbiosis have been associated with many of the same diseases, studies investigating the gut microbiome in the context of sleep disruption have yielded inconsistent results, and have not assessed the fecal metabolome. We exposed mice to five days of sleep disruption followed by four days of ad libitum recovery sleep, and assessed the fecal microbiome and fecal metabolome at multiple timepoints using 16S rRNA gene amplicons and untargeted LC-MS/MS mass spectrometry. We found global shifts in both the microbiome and metabolome in the sleep-disrupted group on the second day of recovery sleep, when most sleep parameters had recovered to baseline levels. We observed an increase in the Firmicutes:Bacteroidetes ratio, along with decreases in the genus Lactobacillus, phylum Actinobacteria, and genus Bifidobacterium in sleep-disrupted mice compared to control mice. The latter two taxa remained low at the fourth day post-sleep disruption. We also identified multiple classes of fecal metabolites that were differentially abundant in sleep-disrupted mice,

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Chronic paradoxical sleep deprivation-induced depressionlike behavior, energy metabolism and microbial changes in rats

Cited by 91 publications

References 91 publications

Alterations in the human gut microbiome in anti‐N‐methyl‐D‐aspartate receptor encephalitis

Alterations in the human gut microbiome in anti‐N‐methyl‐D‐aspartate receptor encephalitis

Associations between disordered gut microbiota and changes of neurotransmitters and short-chain fatty acids in depressed mice

Repeated sleep disruption in mice leads to persistent shifts in the fecal microbiome and metabolome

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Chronic paradoxical sleep deprivation-induced depression­like behavior, energy metabolism and microbial changes in rats

Cited by 91 publications

References 91 publications

Alterations in the human gut microbiome in anti‐N‐methyl‐D‐aspartate receptor encephalitis

Alterations in the human gut microbiome in anti‐N‐methyl‐D‐aspartate receptor encephalitis

Associations between disordered gut microbiota and changes of neurotransmitters and short-chain fatty acids in depressed mice

Repeated sleep disruption in mice leads to persistent shifts in the fecal microbiome and metabolome

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Chronic paradoxical sleep deprivation-induced depressionlike behavior, energy metabolism and microbial changes in rats