Chronic Pancreatitis Is Associated With Disease-Specific Regulatory T-Cell Responses

Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss

“…In chronic pancreatitis, significant increase in CD4 + and CD8 + T-cell infiltration was observed in pancreas of patients with chronic pancreatitis [9]. Moreover, strong IL-10 based T cell response against pancreatitis-associated antigen was found in chronic pancreatitis patients [10]. Further study confirmed that pancreatitis-specific IL-10 responses were mediated by IL-10 + IFN-γ - FoxP3 + regulatory T cells (Tregs).…”

“…Further study confirmed that pancreatitis-specific IL-10 responses were mediated by IL-10 + IFN-γ - FoxP3 + regulatory T cells (Tregs). The expansion of these Tregs helped to suppress conventional T cell response in chronic pancreatitis patients [10]. …”

Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis

“…We wondered whether the observed increase of TNF-α + TCs and TNF-α protein in some CRCs was based on endogenous tumor-specific TC responses in these patients. We therefore assessed the presence of functionally potent, tumor-specific TCs (hereafter referred to as "tumor-reactive") in the blood or bone marrow (which represents a preferred homing site of TA-specific memory TCs) (34-36) from 26 patients with primary CRC by an ex vivo 40-hour short-term IFN-γ ELISPOT assay (15,36,37) and compared the data to the respective amount of TNF-α protein in corresponding tumor tissue. To determine the presence of tumor-reactive TCs, purified CD3 + TCs were stimulated for 40 hours with autologous DCs, which were loaded with 200 μg/ml autologous tumor cell lysate or the same amount of autologous peripheral blood mononuclear cell (PBMC) lysate and/or lysate of autologous normal colonic mucosa as negative control antigen.…”

Simultaneous characterization of pancreatic stellate cells and other pancreatic components within three-dimensional tissue environment during chronic pancreatitis

“…1 Other pancreatic components such as inflammatory cells, blood vessels, and extracellular matrix also play important role in the exocrine pancreatic diseases. [3][4][5] These components are reported to interact with each other and lead to the progression of these diseases conjointly. For example, PSCs respond to inflammatory cytokines, 2 and activated PSCs contribute to the recruitment of inflammatory cells to the inflamed pancreas.…”