Chronic Pain Hurts the Brain: The Pain Physician’s Perspective

Fehér, Gergely; Delia, S.; Rodriguez-Saldana, Joel; Nagy, Ferenc

doi:10.1155/2020/3786562

Cited by 4 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One in five low back pain patients suffered from neuropathic pain and the rate of mixed pain (containing both nociceptive and neuropathic components) was similar. This is in concordance with previous findings, the rate of neuropathic low back pain varied from 16% to 55% [ 5 ].…”

Section: Discussionsupporting

confidence: 94%

“…Chronic pain is a devastating disease, one of the leading causes of disability, which can affect 10–20% of the population [ 4 , 5 ]. Neuropathic pain, which originates from injury or malfunction to the peripheral or central nervous system resulting in maladaptive changes in neurons along the nociceptive pathway can be detected about 30% of chronic pain patients [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neuropathic Low Back Pain and Burnout among Hungarian Workers

Mák

Kapus

Tóth

et al. 2021

IJERPH

View full text Add to dashboard Cite

Burnout is an increasingly prevalent syndrome mainly involving those working in human services. Although it is categorized as an occupational phenomenon and not as a medical condition, it seems to be strongly associated with several diseases such as pain syndromes. However, no studies examined the association between neuropathic low back pain and burnout. This questionnaire-based study was carried out between April 2019 and March 2020 in three main sites among teachers, social workers and healthcare workers. Demographic criteria included age, gender, marital status, number of children, type of work, years spent with work, work schedule, legal relation, secondary employment. Included diseases were diabetes, hypertension, ischemic heart disease, generalized pain (pain involving more than one area of the body) and depression. Low back pain was assessed by the painDETECT questionnaire, burnout was measured with the Maslach Burnout Inventory (MBI) and depression was measured by the Beck Depression Inventory. Dysfunctional attitudes were also recorded. Overall, 1500 questionnaires were successfully delivered and 1141 responses received (response rate of 76%). Three hundred social workers, 399 teachers, 339 paramedics, 35 doctors and 68 medical attendants have completed our survey. In a multivariate analysis including of all factors (demographic criteria, burnout, depression, dysfunctional attitudes, comorbidity etc.) neuropathic low back pain was associated with age > 62 (OR = 3.981, p = 0.01), number of children ≥ 2 (OR = 2.638, p = 0.003), job type (being a social worker) (OR = 6.654, p < 0.001), burnout (OR = 2.577, p < 0.001), current depression (OR = 2.397, p < 0.001), and suffering from generalized pain (OR= 4.076, p < 0.001). This is the first study showing the association of burnout and neuropathic low back pain, which is the most common cause of disability. Based on our results neuropathic low back pain and burnout have similar risk factors and consequences which raises the possibility of similar pathophysiology.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Neuropathic Low Back Pain and Burnout among Hungarian Workers

Mák

Kapus

Tóth

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“… 1 , 2 Representative symptoms of NP include allodynia, hyperalgesia, and spontaneous pain, which adversely affect 10%–20% of the whole population and lead to staggering health care costs. 3 Although many treatments have been developed to treat NP, patients still experience the side effects or tolerance due to long‐term use. 3 , 4 For these patients, neurostimulation techniques such as transcranial magnetic stimulation and deep brain stimulation are required as progressive surgical therapies for the management of malignant pain.…”

Section: Introductionmentioning

confidence: 99%

“… 3 Although many treatments have been developed to treat NP, patients still experience the side effects or tolerance due to long‐term use. 3 , 4 For these patients, neurostimulation techniques such as transcranial magnetic stimulation and deep brain stimulation are required as progressive surgical therapies for the management of malignant pain. 5 , 6 However, only a few regions of the brain, for instance, the motor cortex, anterior cingulate cortex, and thalamus, have been investigated for the clinical trials of brain stimulation in NP, 7 , 8 , 9 and the parameters of brain stimulation are used in various range.…”

Section: Introductionmentioning

confidence: 99%

“…Damaged or dysfunctional nerves due to various causes such as infection or injury can cause the neuropathic pain (NP) 1,2 . Representative symptoms of NP include allodynia, hyperalgesia, and spontaneous pain, which adversely affect 10%–20% of the whole population and lead to staggering health care costs 3 . Although many treatments have been developed to treat NP, patients still experience the side effects or tolerance due to long‐term use 3,4 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Insular cortex stimulation alleviates neuropathic pain via ERK phosphorylation in neurons

et al. 2023

View full text Add to dashboard Cite

Aims The clinical use of brain stimulation is attractive for patients who have side effects or tolerance. However, studies on insular cortex (IC) stimulation are lacking in neuropathic pain. The present study aimed to investigate the effects of IC stimulation (ICS) on neuropathic pain and to determine how ICS modulates pain. Methods Changes in pain behaviors were observed following ICS with various parameters in neuropathic rats. Western blotting was performed to assess molecular changes in the expression levels of phosphorylated extracellular signal‐regulated kinase (pERK), neurons, astrocytes, and microglia between experimental groups. Immunohistochemistry was performed to investigate the colocalization of pERK with different cell types. Results The most effective pain‐relieving effect was induced at 50 Hz–120 μA in single trial of ICS and it maintained 4 days longer after the termination of repetitive ICS. The expression levels of pERK, astrocytes, and microglia were increased in neuropathic rats. However, after ICS, the expression levels of pERK were decreased, and colocalization of pERK and neurons was reduced in layers 2–3 of the IC. Conclusion These results indicated that ICS attenuated neuropathic pain by the regulation of pERK in neurons located in layers 2–3 of the IC. This preclinical study may enhance the potential use of ICS and identify the therapeutic mechanisms of ICS in neuropathic pain.

show abstract