Chronic Obstructive Pulmonary Disease Predicts Chronic Rhinosinusitis without Nasal Polyps: A Population-Based Study

Wang

et al. 2016

Sci Rep

Self Cite

Few studies have investigated the relationship between chronic rhinosinusitis (CRS) and erectile dysfunction (ED). This case-control study aimed to investigate the association between CRS and the risk of ED in a large national sample. Tapping Taiwan’s National Health Insurance Research Database, we identified people 30 years or older with a new primary diagnosis of CRS between 1996 and 2007. The cases were compared with sex- and age-matched controls. We identified 14 039 cases and recruited 140 387 matched controls. Both groups were followed up in the same database until the end of 2007 for instances of ED. Of those with CRS, 294 (2.1%) developed ED during a mean (SD) follow-up of 3.20 (2.33) years, while 1 661 (1.2%) of the matched controls developed ED, mean follow up 2.97 (2.39) years. Cox regression analyses were performed adjusting for sex, age, insurance premium, residence, hypertension, hyperlipidemia, diabetes, obesity, coronary heart disease, chronic kidney disease, chronic obstructive pulmonary disease, asthma, allergic rhinitis, arrhythmia, ischemic stroke, intracerebral hemorrhage, and medications. CRS was revealed to be an independent predictor of ED in the fully adjusted model (HR = 1.51; 95% CI = 1.33–1.73; P < 0.0001).

Section: Methodsmentioning

confidence: 99%

Chronic Rhinosinusitis Associated with Erectile Dysfunction: A Population-Based Study

Wang

et al. 2016

Sci Rep

Self Cite

The Journal of Allergy and Clinical Immunology: In Practice

“…13,17 A Taiwan population-based study also demonstrated that chronic obstructive pulmonary disease (COPD) is independently associated with CRSsNP. 18 …”

Section: Phenotypes and Endotypesmentioning

confidence: 99%

Chronic Rhinosinusitis without Nasal Polyps

Cho

Kim

Gevaert

2016

Chronic rhinosinusitis without nasal polyps (CRSsNP) is more prevalent than chronic rhinosinusitis with nasal polyps (CRSwNP). Certain diseases predispose to whereas others are associated with CRSsNP. Predisposing diseases include allergic and non-allergic upper and lower airway diseases, epithelial cell disorders, immunodeficiencies, autoimmune diseases, and some infectious diseases. Additionally, environmental and host factors, examples of which include smoking, a higher incidence of abnormal biofilms, and innate immune defects play a role in the pathogenesis of this disease. CRSsNP is characterized by histologic abnormalities, including basement membrane thickening (fibrosis) and goblet cell hyperplasia. Neutrophils and several chemokines, TGF-β and CXCL-8, play a role in CRSsNP remodeling. However, there are conflicting data about CRSsNP endotypes, e.g., whether it is characterized by neutrophilia or eosinophilia or both. In spite of advancements and the understanding of the pathogenesis of this disease, additional study is necessary to better comprehend its underlying mechanisms, endotypes, and evidence based treatment strategies.

“…Cases and controls were followed for both CRSwNP and CRSsNP as outcomes. Following previous studies, ICD‐9‐CM codes for CRS were 473, 473.0, 473.1, 473.2, 473.3, 473.8, and 473.9. Those for CRSwNP and CRSsNP were 471, 471.0, 471.1, 471.8, and 471.9.…”

Section: Methodsmentioning

confidence: 99%

Asthma associated with chronic rhinosinusitis: a population‐based study

Chen

Chien

Int Forum Allergy Rhinol

et al. 2016

Self Cite