Chronic obstructive pulmonary disease as a risk factor for suicide: A systematic review and meta-analysis

Abstract

Background: Patients living with chronic obstructive pulmonary disease (COPD) commonly present several limitations in their daily activities, high depression rates, and low quality of life, which makes this population a risk group for suicide. This study aims to systematically assess the literature on the association between CPOD and the likelihood of suicide. Methods: The protocol was registered in PROSPERO (CRD42018096618). The Latin-American and Caribbean Health Sciences Literature (LILACS), PubMed, SciELO, Scopus, LIVIVO, Web of Science, and PsychNET databases were used as primary study sources. OpenThesis and OpenGrey were used to partially capture the "grey literature". A manual search was also performed through a systematized analysis of the references of eligible articles. The risk of bias among the studies included was assessed with the Joanna Briggs Institute Critical Appraisal Tools for Systematic Reviews. A random effects meta-analysis was performed to estimate the variation in odds ratio (OR) and 95% confidence intervals (95% CI). Results: The search provided 4762 results, from which only seven met the eligibility criteria and were ultimately included in the qualitative assessment of the review. The studies were published from 2002 to 2015. All studies presented low risk of bias. The total sample included 1390 suicide cases of COPD patients. The meta-analysis, which was based on five eligible case control studies, found that people with history of COPD are more likely to commit suicide (OR = 1.90; 95% CI = 1.27-2.48; p = 0.002). Conclusion: COPD patients are 1.9 times more likely to commit suicide than people without COPD.

Is There Association Between Stress and Bruxism? A Systematic Review and Meta-Analysis

“…The risk of bias was scored as Low when the study reached over 70% of the "yes" score, Moderate when the study reached from 50 to 69% of the "yes" score and High when the study reached up to 49% of "yes" score. Studies characterized as a "high risk of bias" were excluded (20,21). The guidelines of evaluation criteria are described in Supplementary Table 3.…”

Response to letter regarding Tobacco smoking

“…Conversely, indirect markers or proxy measurements for smoking may be found in hospital register. Numerus smoking-related disorders have been linked to suicide [6], for instance, head and neck cancers [7], lung cancer [8] and chronic obstructive pulmonary disease [9]. Interestingly, these disorders were included in the Charlson Comorbidity Index, which was used as an adjusting covariate in our reported findings.…”

Chronic Lung Diseases and the Risk of Depressive Symptoms Based on the China Health and Retirement Longitudinal Study: A Prospective Cohort Study

“…The risk factors of depression over the 40 years of research were cognitive ability and cognitive process; unbearable stressors; certain sociodemographic factors, such as being female and living in a rural area; heredity; and so on (Seedat et al, 2009;Stein et al, 2014;Hammen, 2018). In addition, recent researches have presented that chronic lung disease (CLD) was the independent risk factor for depressive symptoms (Xiao et al, 2018;Sampaio et al, 2019). However, no conclusive evidences were wellestablished; the majority of studies were based on cross-sectional or convenience samples studies (van den Bemt et al, 2009;Crump et al, 2014).…”