Chronic nonhereditary blistering disease in children

Bean, Samuel F.

doi:10.1001/archderm.110.6.941

Cited by 22 publications

(11 citation statements)

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“…In early adolescence, we identified nine BP cases (six women, two men; in one, sex was not reported). [5][6][7][8][9][10][11][12] Mucosa were affected in 5 of 9 cases. Treatment consisted of systemic prednisone (8/9), in combination with dapsone (2/9), azathioprine (2/9), or erythromycin/ nicotinamide (1/9).…”

Section: Resultsmentioning

confidence: 99%

“…6 The first case of bullous pemphigoid in childhood, in an 11-yearold, was diagnosed by immunofluorescence findings by Bean et al in 1970. 5 Since then, 8 cases of BP in early adolescence have been described ( Table 1). The clinical features of BP in this age range include a pruritic generalized bullous eruption, similar to the adult BP, with frequent involvement of the oral mucosa.…”

Section: Discussionmentioning

confidence: 99%

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Bullous pemphigoid in adolescence

Patsatsi

Kyriakou

Werth

2018

Pediatric Dermatology

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Bullous pemphigoid (BP) is the most common autoimmune blistering disease affecting the elderly but is quite rare in childhood. The majority of pediatric cases have been reported during early childhood. Adolescence is divided into three phases: early (10‐13 years), middle (14‐17), and late (18‐21). This review aimed to identify BP cases in adolescence and demonstrate their clinical features and course. Our literature search was performed in Medline with the terms “bullous pemphigoid in childhood and adolescence,” “childhood bullous pemphigoid,” “juvenile bullous pemphigoid,” and “autoimmune blistering and autoimmune bullous diseases in childhood.” The data extraction for late adolescence was limited by the fact that this age group is included in adult BP registries. We identified nine cases in early adolescence. Mucosa were affected in 5 of 9 cases. Treatment consisted of systemic prednisone (8/9), in combination with dapsone (2/9), azathioprine (2/9), or erythromycin/nicotinamide (1/9). Relapses were reported in 3 of 9 cases. We identified five cases occuring in middle adolescence. Mucosa were not affected. Treatment consisted of systemic prednisone (5/5), in combination with dapsone (3/5), azathioprine (2/5), doxycycline/nicotinamide (1/5), or mycophenolate mofetil (1/5). Relapses were reported in two of five cases. No case of BP in the late adolescence was included in the results, as only one case met the search criteria, and overlapped with pemphigus vulgaris. With only 14 cases found in our review, BP in adolescence appears even rarer than in earlier childhood. Despite its low prevalence, BP should be included in the differential diagnosis of autoimmune blistering diseases in adolescents.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bullous pemphigoid in adolescence

Patsatsi

Kyriakou

Werth

2018

Pediatric Dermatology

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“…The question is posed as to whether these latter patients will eventually develop pemphigus, or are they suffering from some other, as yet unclassifiable, bullous disease ? They may have a condition analagous to chronic non-hereditary bullous disease in childhood (Bean et al, 1971). This widespread bullous eruption simulates juvenile bullous pemphigoid closely but is characterized by the presence of eosinophils in the epidermis and upper dermis with repeatedly negative direct and indirect immunofluorescence.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic spongiosis. A CLINICAL HISTOLOGICAL AND IMMUNOFLUORESCENT CORRELATION

1976

Clin Exp Dermatol

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Summary This report gives an account of nine patients, all females, with the histological finding of eosinophilic spongiosis. Six of them had positive intercellular antibodies on direct immunofluorescence but only two had circulating pemphigus antibodies. The clinical presentations of those with proven pemphigus resembled bullous pemphigoid in one, dermatitis herpetiformis in another, whereas the remainder were more typical of pemphigus foliaceus or vulgaris. Three patients had negative immunofluorescence. They may still develop pemphigus or alternatively could have some unclassifiable bullous dermatosis.

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“…The eruption usually appears after the age of 6, mainly on the knees, elbows, buttocks and scalp (Ackerman & Tolman, 1969); oral lesions are rare . As in adults, there is a dramatic response to treatment with dapsone or sulphapyridine Jablonska et al, 1971;Bean & Jordon, 1974;Chorzelski et al, 1975). In a recent study of children with dermatitis herpetiformis, HLA B8 was found in five out of seven cases (Thune et al, 1978).…”

Section: Dermatitis Herpetiformismentioning

confidence: 99%

The chronic acquired bullous diseases of childhood

Marsden¹,

Skeete²,

Black³

1979

Clin Exp Dermatol

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Due to their rarity, the chrotiic acquired bullous diseases of childhood have not yet beeti studied in detail. Constant changes in terminology and classification have so far achieved little apart from confusing clinicians. We have attempted, therefore, to interpret the literature, to define the diseases in question and have included some case reports of patients seen recently at St John's Hospital for Diseases of the Skin. The pemphigus groupWhen pemphigus occurs in children, the disease is chtiically, histologically and immunologically similar to that in adults. Beutner & Chorzelski (1976) reviewed 234 cases of pemphigus and found that the disease began before the age of 10 in four cases and between 11 and 20 years in nine. Eleven of these cases were female, an incidence 5-5 times higher than in other age groups, where the sexes are equally affected. This female preponderance in children with pemphigus has been noted elsewhere (Jordon et al, 1976). It is of interest that a much larger proportion of affected children had pemphigus foliaceus or erythematosus (sis out of thirteen cases) compared with adults (twenty-seven out of 221 cases).

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Chronic nonhereditary blistering disease in children

Cited by 22 publications

References 0 publications

Bullous pemphigoid in adolescence

Bullous pemphigoid in adolescence

Eosinophilic spongiosis. A CLINICAL HISTOLOGICAL AND IMMUNOFLUORESCENT CORRELATION

The chronic acquired bullous diseases of childhood

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