2018
DOI: 10.1111/pde.13717
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Bullous pemphigoid in adolescence

Abstract: Bullous pemphigoid (BP) is the most common autoimmune blistering disease affecting the elderly but is quite rare in childhood. The majority of pediatric cases have been reported during early childhood. Adolescence is divided into three phases: early (10‐13 years), middle (14‐17), and late (18‐21). This review aimed to identify BP cases in adolescence and demonstrate their clinical features and course. Our literature search was performed in Medline with the terms “bullous pemphigoid in childhood and adolescence… Show more

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Cited by 16 publications
(17 citation statements)
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References 20 publications
(32 reference statements)
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“…Of the nine reported cases in early adolescence, six had generalised eruptions, one was localised to the vulva, and four had mucosal involvement. The lesions in the middle adolescence group tended to be more generalised with no mucosal involvement reported prior to our case study 1 …”
Section: Discussionsupporting
confidence: 50%
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“…Of the nine reported cases in early adolescence, six had generalised eruptions, one was localised to the vulva, and four had mucosal involvement. The lesions in the middle adolescence group tended to be more generalised with no mucosal involvement reported prior to our case study 1 …”
Section: Discussionsupporting
confidence: 50%
“…Late adolescents are often classified as adults so any unique features in this group are unknown. It is very rare in early and middle adolescence with only nine cases in early adolescence and five cases in middle adolescence reported in the literature 1 . Of the nine reported cases in early adolescence, six had generalised eruptions, one was localised to the vulva, and four had mucosal involvement.…”
Section: Discussionmentioning
confidence: 99%
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“…Lebensjahr) betrifft . In sehr seltenen Fällen kann es auch Kinder und in extrem seltenen Fällen auch Jugendliche betreffen; insgesamt wurden bislang nur 9 Fälle publiziert, in denen das BP in einem Alter zwischen 10–13 Jahren erstmals auftrat .…”
Section: Kommentarunclassified
“…1 Its incidence and prevalence during childhood is unknown, being extremely rare with only nine reports of cases occurred during early adolescence. [2][3][4] Autoimmune bullous disorders are due to autoantibodies generated against target antigens; in this way one typical serologic characteristic of BP is the presence of circulating autoantibodies against BP180 (collagen XVII) and BP230. 5 BP180 is a 180 kDa transmembrane glycoprotein with a 16th non-collagenous domain, and BP230 is an intracellular constituent of the hemidesmosomal plaque which belongs to the spectraplakin family.…”
mentioning
confidence: 99%