Chronic non-cancer pain in adolescents: a narrative review

Silva, Carlos; Oliveira, Dora Lúcia Leidens Corrêa de; Pestana-Santos, Márcia; Portugal, Francisco; Capelo, Paula

doi:10.1016/j.bjane.2021.04.033

Cited by 8 publications

(15 citation statements)

References 79 publications

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“…A large proportion of youth in the US suffer from chronic pain that can be debilitating. The highest predictors for adult chronic pain are the occurrence of adolescent obesity and chronic pain [30]. Little is known about the etiology of this phenomenon despite the deleterious impact.…”

Section: Discussionmentioning

confidence: 99%

Lipid signatures of chronic pain in female adolescents with and without obesity

et al. 2022

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Background Chronic pain in adolescence is associated with diminished outcomes, lower socioeconomic status in later life, and decreased family well-being. Approximately one third of adolescents with chronic pain have obesity compared to the general population. In obesity, lipid signals regulate insulin sensitivity, satiety, and pain sensation. We determined whether there is a distinct lipid signature associated with chronic pain and its co-occurrence with obesity in adolescents. Methods We performed global lipidomics in serum samples from female adolescents (N = 67, 13–17 years old) with no pain/healthy weight (Controls), chronic pain/healthy weight (Pain Non-obese), no pain/obesity (Obese), or chronic pain/obesity (Pain Obese). Results The Pain Non-obese group had lipid profiles similar to the Obese and Pain Obese groups. The major difference in these lipids included decreased lysophosphatidylinositol (LPI), lysophosphatidylcholine (LPC), and lysophosphatidylethanolamine (LPE) in the three clinical groups compared to the Control group. Furthermore, ceramides and sphingomyelin were higher in the groups with obesity when compared to the groups with healthy weight, while plasmalogens were elevated in the Pain Obese group only. Conclusions Serum lipid markers are associated with chronic pain and suggest that specific lipid metabolites may be a signaling mechanism for inflammation associated with co-occurring chronic pain and obesity.

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Section: Discussionmentioning

confidence: 99%

Lipid signatures of chronic pain in female adolescents with and without obesity

et al. 2022

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“…Хроническое воспаление -фон, вызывающий постоянную активацию и сенситизацию периферических нервных окончаний ноцицептивных нейронов. Следствием этого становится периферическая сенситизация (ПС) -процесс, обусловленный активацией (открытием) ряда потенциал-и лиганд-зависимых трансмембранных ионных (Na + , K + , Ca 2+ ) каналов, что способствует снижению мембранного потенциала и потенциала действия ноцицептора [27][28][29][30].…”

Section: хнбс: патофизиологические аспекты связанныеunclassified

“…задних рогов спинного мозга (ЗРСМ) [29,30]. Повторные эпизоды деполяризации мембран нейронов создают условия для накопления в перисинаптическом пространстве нейромедиаторов и нейротрофинов.…”

Section: хнбс: патофизиологические аспекты связанныеunclassified

Chronic back pain as a spinal osteoarthritis manifestation: rationale and practice of symptomatic slow acting drugs for osteoarthritis use

Karateev¹

2022

Sovremennaâ revmatologiâ

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Chronic non-specific back pain (CNBP) is the most common pathology of the musculoskeletal system, affecting from 10 to 60% of the adult population in the world, causing severe suffering, disability and a significant deterioration in the quality of life. Osteoarthritis (OA) should be considered as one of the main reasons of the development of CNBP – inflammatory and degenerative changes in the facet and sacroiliac joints, as well as the spinal column itself (in particular, osteitis of the Modic 1 type). Spinal OA is accompanied by biomechanical disturbances, nociplastic (peripheral and central sensitization) and psycho-emotional changes that form a complete picture and various CNBP phenotypes.Recognizing the leading role of OA as the cause of CNBP, it is advisable to use the same therapeutic approaches in this syndrome as in OA of peripheral joints. In particular, it is necessary to consider the use of symptomatic slow acting drugs for osteoarthritis (SYSADOA) in CNBP as the main pathogenetic therapy.Alflutop is one of the most popular parenteral SYSADOA widely used in Russian practice. This drug has a good evidence base: this review presents data from 12 clinical trials of Alflutop in CNBP (n=1479), which confirmed its efficacy and safety.

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“…There are different hypotheses around the rationale for this inequality: one is sex-linked factors, like hormones and reproductive factors (20)(21)(22), another is it related to discrepancies in the social and cultural experiences between genders (23)(24)(25), leading to forms of gendered stress. While systematic reviews have attested to the unequal distribution of CP in childhood and adolescence (26,27) and older age (13,17,18,(28)(29)(30)(31)(32), the evidence is less clear about the prevalence of CP by sex at mid-life -a period with distinct social and physical challenges where growth is balanced with decline (33), related to heightened socioeconomic responsibilities and physiological changes, like the menopause. CP prevalence increases with age (19,34), yet some evidence shows that the burden of pain is increasing for increasingly younger cohorts (35).The mid-life is a potentially sensitive period that may provide an arena for prevention and management interventions to decrease the burden of CP later in life.…”

Section: Introductionmentioning

confidence: 99%

Differences In Chronic Pain Prevalence Between Men And Women At Mid-Life: A Systematic Review Protocol

Borra

Hardy

2021

Preprint

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Background: Epidemiological literature has revealed differences in chronic pain (CP) prevalence in men and women. Women have been found to be more likely to develop CP compared to men at different points of the life-course, such as childhood and old age. Less is known about differences in prevalence by sex during mid-life. While CP is most prevalent later in life, biological and physical changes in mid-life may predispose to an earlier differentiation in CP distribution – for example due to the menopause. The aim of this study is to describe the prevalence of CP at midlife in men and women, and to identify how these differences relate to results pertaining to other periods in the life-course. Methods: This systematic review follows PRISMA guidelines. An electronic search will identify appropriate studies in the following databases: MEDLINE, to be accessed through Web of Science; and EMBASE, AMED and PSYCHinfo to be accessed through OVID. Two reviewers will independently screen each title and abstract and subsequently each full text following the inclusion criteria outlined in this protocol. The reference lists of eligible papers will also be screened to identify any further eligible studies. Any inconsistencies between reviewer decisions will be resolved through discussion. Studies eligible for data extraction will report estimates of CP prevalence, of prevalence for each sex, and difference in prevalence between sexes. Two reviewers will conduct data extraction using a standardised data extraction form. Quality assessment will be conducted using a risk of bias assessment tool for prevalence studies. The findings will be reported in a narrative synthesis and will comment on expected heterogeneity, following the Social Research Council Methods Programme guidelines. A random effects meta-analysis will be conducted where the reviewers can justify combining results.Discussion: This review will summarise the prevalence of CP in men and women at mid-life, based on existing evidence. It is expected that the results will identify gaps in knowledge and areas for further research.Systematic review registration: PROSPERO: CRD42021295895

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Chronic non-cancer pain in adolescents: a narrative review

Cited by 8 publications

References 79 publications

Lipid signatures of chronic pain in female adolescents with and without obesity

Lipid signatures of chronic pain in female adolescents with and without obesity

Chronic back pain as a spinal osteoarthritis manifestation: rationale and practice of symptomatic slow acting drugs for osteoarthritis use

Differences In Chronic Pain Prevalence Between Men And Women At Mid-Life: A Systematic Review Protocol

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