2021
DOI: 10.21203/rs.3.rs-455083/v1
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Abstract: Preclinical studies have revealed that the elevation of nicotinamide adenine dinucleotide (NAD+) levels on administration of an NAD+ precursor, nicotinamide mononucleotide (NMN), can mitigate aging-related disorders; however, human data are sparse. Therefore, we aimed to investigate whether the chronic oral supplementation of NMN can elevate blood NAD+ levels and alter physiological dysfunctions, including muscle weakness, in healthy elderly participants. We administered 250 mg NMN per day to aged men for 6 or… Show more

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“…The initial results from this study seem to be signalling in the positive direction, but further large-scale trials with an increase in dose and duration of treatment are required to establish distinctive conclusions with statistical significance. This study opens up whole new horizons for trying NMN in areas like aging reversal, specific organ regeneration based on anti-aging and age-reversing effects, reversal of metabolic disorders, and even NMN’s effect on cancer prevention ( Knip et al, 2000 ; Hwang and Song, 2020 ; Igarashi et al, 2021 ).…”
Section: Discussionmentioning
confidence: 95%
“…The initial results from this study seem to be signalling in the positive direction, but further large-scale trials with an increase in dose and duration of treatment are required to establish distinctive conclusions with statistical significance. This study opens up whole new horizons for trying NMN in areas like aging reversal, specific organ regeneration based on anti-aging and age-reversing effects, reversal of metabolic disorders, and even NMN’s effect on cancer prevention ( Knip et al, 2000 ; Hwang and Song, 2020 ; Igarashi et al, 2021 ).…”
Section: Discussionmentioning
confidence: 95%