A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults

Abstract

Objective: The purpose of the study was to evaluate the anti-aging effect of NMN and its safety in a double-blind, parallel, randomised controlled clinical trial.Methods: The study was carried out on 66 healthy subjects between the ages of 40 and65 years, instructed to take two capsules (each containing 150 mg. of NMN or starch powder) once a day after breakfast for 60 days.Results: At day 30, NAD+/NADH levels in the serum showed a noteworthy increase, i.e., by 11.3%, whereas the placebo group had shown no change at all. At the end of the study, i.e., day 60, the NAD+/NADH levels were increased further by 38% compared to baseline, against a mere 14.3% in the placebo group. In the case of SF 36, at day 60, the Uthever group showed a rise of 6.5%, whereas the placebo group was merely raised by 3.4%. At the end of the study, the mean HOMA IR Index showed a rise of 0.6% among the Uthever group and 30.6% among the Placebo group from baseline.Conclusion: The rise in the levels of NAD+/NADH at day 30 and day 60 illustrated the potential of Uthever to raise the levels of NAD+ in the cells, which is linked to higher energy levels and an anti-aging effect. Increased sensitivity to insulin has also been linked to anti-aging. There was no noteworthy change in HOMA score, in the Uthever group whereas there was a noteworthy rise in the placebo group, demonstrating the anti-aging effect of Uthever as in its absence, the parameters worsened.Clinical Trial Registration: (clinicaltrials.gov), identifier (NCT04228640 NMN).

Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo‐controlled, double‐blind study

“…Several clinical studies examining the effects of NMN in humans have already been reported 9,11–15 . Both single supplementation of NMN at 100–500 mg 11 and its daily administration at 250–300 mg/day 9,12,13 increased NMN metabolites, including NAD + .…”

“…Previous studies examined other phenotypes of the effects of NMN on humans by evaluating the quality‐of‐life using the SF‐36 scale in healthy participants, 12 sleep quality using the Pittsburgh Sleep Quality Index and subjective fatigue using a questionnaire in older adults 14 . The favorable effect of NMN was observed on a few indicators, but the impact was unclear in the overall evaluation.…”

“…Several clinical studies examining the effects of NMN in humans have already been reported. 9,[11][12][13][14][15] Both single supplementation of NMN at 100-500 mg 11 and its daily administration at 250-300 mg/day 9,12,13 increased NMN metabolites, including NAD + . Increased intracellular NAD + levels can enhance mitochondrial function, and insulin signaling and sensitivity in skeletal muscles.…”

Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan

“…NMN supplementation has had numerous benefits, ranging from cardiovascular to neurodegenerative disease contexts, and proper uptake and resulting biosynthesis of NAD+ is observed in varying tissue types [ 70 , 71 , 72 ]. A successful increase in intracellular NAD+/NADH ratio was evident in a clinical trial in adults aged 40 to 65 years over 60 days at a dosage of 300 mg daily, providing key safety and efficacy data to support the use of NMN Uthever TM as a valid interventional approach to increase NAD+ in a safe manner [ 73 ]. NMN supplementation has also been shown to target one of the hallmarks of aging, telomere attrition.…”

Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan

“…NMN supplementation has had numerous benefits, ranging from cardiovascular to neurodegenerative disease contexts, and proper uptake and resulting biosynthesis of NAD+ is observed in varying tissue types [60][61][62]. Successful increase in intracellular NAD+/NADH ratio was evident in a clinical trial in adults aged 40 to 65 over 60 days at a dosage of 300 mg, providing key safety and efficacy data to support the use of NMN Uthever TM as a valid interventional approach to increase NAD+ in a safe manner [63]. NMN supplementation has also been shown to target one of the hallmarks of aging, telomere attrition; short-term supplementation of NMN in pre-aging mice and humans, ages 45 to 60, showed a significant increase in telomere length in peripheral blood mononuclear cells, as well as altered faecal microbiota towards the benefit of immune and metabolic pathways [64], where specific administration in mice has been shown to increase the ratio of beneficial to harmful gut bacteria strains [65].…”