Chronic neuropathic pain severity is determined by lesion level in aquaporin 4-antibody-positive myelitis

Tackley, George; Vecchio, Domizia; Hamid, Shahd; Juryńczyk, Maciej; Kong, Yazhuo; Gore, Rosie; Mutch, Kerry; Woodhall, Mark; Waters, Patrick; Vincent, Angela; Leite, Maria Isabel; Tracey, Irene; Jacob, Anu; Palace, Jacqueline

doi:10.1136/jnnp-2016-314991

Cited by 38 publications

(42 citation statements)

References 14 publications

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“…### p < 0.001 vs. control group, ***p < 0.01, vs. SCI group and vehicle, $ p < 0.05, $$$ p < 0.001 vs. laser group. ¥¥¥ p < 0.001 vs. hADSc group studies showed the upregulation of AQP4 could also lead to neuropathic pain [68][69][70][71]. In the present study, AQP4 expression is significantly increased in SCI group.…”

Section: Discussionsupporting

confidence: 51%

Co-administration of human adipose-derived stem cells and low-level laser to alleviate neuropathic pain after experimental spinal cord injury

et al. 2019

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Background: Evidence has suggested that human adipose-derived stem cells (hADSCs) and low-level laser has neuroprotective effects on spinal cord injury (SCI). Therefore, the combined effect of the hADSCs and laser on neuregeneration and neuropathic pain after SCI was investigated. Methods: Forty-eight adult male Wistar rats with 200-250 g weight were used. Thirty minutes after compression, injury with laser was irritated, and 1 week following SCI, about 1 × 10 6 cells were transplanted into the spinal cord. Motor function and neuropathic pain were assessed weekly. Molecular and histological studies were done at the end of the fourth week. Results: The combined application of hADSCs and laser has significantly improved motor function recovery (p = 0.0001), hyperalgesia (p < 0.05), and allodynia (p < 0.05). GDNF mRNA expression was significantly increased in hADSCs and laser+hADSC-treated animals (p < 0.001). Finally, co-administration of hADSCs and laser has enhanced the number of axons around cavity more than other treatments (p < 0.001). Conclusions: The results showed that the combination of laser and ADSCs could significantly improve the motor function and alleviate SCI-induced allodynia and hyperalgesia. Therefore, using a combination of laser and hADSCs in future experimental and translational clinical studies is suggested.

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Section: Discussionsupporting

confidence: 51%

Co-administration of human adipose-derived stem cells and low-level laser to alleviate neuropathic pain after experimental spinal cord injury

et al. 2019

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“…A previous study reported a similar incidence of fatigue in NMOSD and MS patients, with a strong correlation between depression and fatigue [9]. On the other hand, chronic pain is a common symptom causing deterioration of activities of the daily living in patients with MS and NMOSD [15][16][17]. However, the relationship between fatigue and pain has not been fully investigated, particularly in NMOSD patients.…”

Section: Introductionmentioning

confidence: 96%

Difference in fatigue and pain between neuromyelitis optica spectrum disorder and multiple sclerosis

et al. 2020

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ObjectiveTo investigate the difference of fatigue and pain in patients with neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). MethodsData from the Modified Fatigue Impact Scale (MFIS) and Pain Effects Scale (PES) were compared between 51 NMOSD and 85 MS patients. Each score was compared in each disease group with or without clinical abnormalities. Since almost no MS patients are without brain magnetic resonance imaging abnormalities, volumetry analysis by the Lesion Segmentation Tool and statistical parametric mapping 12 were added to obtain total lesion volume and intracranial volume in MS patients, and the correlations between total lesion volume/intracranial volume and each score were investigated. ResultsCompared to the MS group, the NMOSD group showed a higher PES score (median, 15.0 vs. 7.0, P = 0.045), no difference in MFIS, and an increased percentage of patients with extended spinal cord lesions (58.8% vs. 8.2%, P < 0.001). Moreover, NMOSD and MS patients with extended spinal cord lesions tended to demonstrate higher PES scores than those without. A positive correlation between MFIS and PES were found in patients with NMOSD and MS. On the other hand, MS patients showed a higher percentage of brain abnormalities (80.4% vs. 97.6%, P = 0.001) and a positive correlation between total lesion volume/intracranial volume and MFIS (Spearman's ρ = 0.50, P = 0.033). ConclusionsThe origin of fatigue may be associated with spinal cord lesions causing pain in NMOSD patients, but with brain lesions in MS patients.

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“…Expression of the water channel aquaporin-4 (AQP4) is induced in spinal cord astrocytes after spinal cord injury in rats 51 and nerve injury in humans 108 . The specific role of AQP4 in animal models of neuropathic pain remains to be determined.…”

Section: Introductionmentioning

confidence: 99%

Astrocytes in chronic pain and itch

2019

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Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence suggests that a number of neurological and neuropsychiatric disorders, including chronic pain, may result from astrocyte 'gliopathy'. Indeed, in recent years there has been substantial progress in our understanding of how astrocytes can regulate nociceptive synaptic transmission via neuronal-glial and glial-glial cell interactions, as well as the involvement of spinal and supraspinal astrocytes in the modulation of pain signaling and the maintenance of neuropathic pain. A role of astrocytes in the pathogenesis of chronic itch is also emerging. These developments suggest that targeting the specific pathways that are responsible for astrogliopathy may represent a novel approach to develop therapies for chronic pain and chronic itch.

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Chronic neuropathic pain severity is determined by lesion level in aquaporin 4-antibody-positive myelitis

Cited by 38 publications

References 14 publications

Co-administration of human adipose-derived stem cells and low-level laser to alleviate neuropathic pain after experimental spinal cord injury

Co-administration of human adipose-derived stem cells and low-level laser to alleviate neuropathic pain after experimental spinal cord injury

Difference in fatigue and pain between neuromyelitis optica spectrum disorder and multiple sclerosis

Astrocytes in chronic pain and itch

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