Chronic Nasal Instillation of Residual-Oil Fly Ash (ROFA) Induces Brain Lipid Peroxidation and Behavioral Changes in Rats

Zanchi, Ana Claudia; Venturini, Carina Duarte; Saiki, M.; Saldiva, Paulo Hilário Nascimento; Barros, Helena Maria Tannhauser; Rhoden, Cláudia Ramos

doi:10.1080/08958370802009060

Cited by 27 publications

(10 citation statements)

References 32 publications

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“…Interestingly, upregulation of pro-inflammatory markers such as COX 2 and IL1-β, as well as the CD-14 marker for innate immune cells, were localized in frontal cortex, substantia nigra and vagus nerves 27. Further, animal studies have also shown that air pollution causes cytokine production 29, 30, increases in MAP kinase signaling through JNK 30, neurochemical changes 31, lipid peroxidation 32, behavior changes 32, and enhanced NFκβ expression 29. Together, these studies clearly indicate that air pollution has CNS effects.…”

Section: Air Pollution and Cns Diseasementioning

confidence: 99%

Air pollution: mechanisms of neuroinflammation and CNS disease

Block

Calderón‐Garcidueñas

2009

Trends in Neurosciences

1,236

953

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Emerging evidence implicates air pollution as a chronic source of neuroinflammation, reactive oxygen species (ROS), and neuropathology instigating central nervous system (CNS) disease. Stroke incidence, and Alzheimer’s and Parkinson’s disease pathology are linked to air pollution. Recent reports reveal that air pollution components reach the brain. Further, systemic effects known to impact lung and cardiovascular disease also impinge upon CNS health. While mechanisms driving air pollution-induced CNS pathology are poorly understood, new evidence suggests that activation of microglia and changes in the blood brain barrier may be key to this process. Here, we summarize recent findings detailing the mechanisms through which air pollution reaches the brain and activates the resident innate immune response to become a chronic source of pro-inflammatory factors and ROS culpable in CNS disease.

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Section: Air Pollution and Cns Diseasementioning

confidence: 99%

Air pollution: mechanisms of neuroinflammation and CNS disease

Block

Calderón‐Garcidueñas

2009

Trends in Neurosciences

1,236

953

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“…The locomotor activity was measured when the animal puts all four paws in each quadrant. All other events like rearing and grooming were assessed (Zanchi et al 2010). After each trial, the open field was cleaned with 70 % ethanol solution.…”

Section: Open-field and Elevated Plus-maze Testsmentioning

confidence: 99%

Brain DNA damage and behavioral changes after repeated intermittent acute ethanol withdrawal by young rats

et al. 2015

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“…Environmental chemicals present currently or historically in coal, coal extraction, and coal processingincluding phthalates, alkylphenols, polychlorinated biphenyls (PCBs), polychlorinated dibenzodioxins, bisphenol A, lead, mercury, zinc, aluminum, and cadmiumare known to impact cognitive development and function (Gladen et al, 1988;Jacobson and Jacobson, 1996;Koger, Schettler and Weiss (2005;Patandin et al, 1999;Schantz and Widholm, 2001;Zanchi et al, 2008). Three mechanistic explanations have been proposed for impaired cognitive development and learning capacity: (1) interference with the endocrine system (Schantz and Widholm, 2001;Bloom et al, 2009;Stefanidou, Maravelias, and Spiliopoulou, 2009);…”

Section: Introductionmentioning

confidence: 98%

Learning Outcomes among Students in Relation to West Virginia Coal Mining: an Environmental Riskscape Approach

Cain

Hendryx

2010

Environmental Justice

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Children who live in coal mining areas are subject to environmental and socioeconomic risks for poor cognitive developmental outcomes. To assess the potential impact of the coal mining environmental riskscape on cognitive development in West Virginian children, we examined the associations between coal mining and learning outcomes among students in West Virginia public schools for the years 2005-2008. The study used a retrospective, natural field experiment design to test pass rates on standardized school performance tests in counties in West Virginia with and without coal mining activity. SUDAAN regression models controlled for a set of other risk variables on test performance. Proficiency rates for schools in coalmining counties versus non-coal mining counties were significantly lower in all subject areas partly in relation to socioeconomic disadvantage, and remained significantly lower (p < .0008 or better) after adjusting for county high school education rates, percent of low-income students, percent of highly qualified teachers, number of students tested, and county smoking rates. Disparities in educational performance in mining areas reflect multiple environmental riskscape disadvantages. Adjusted differences in school test performance may reflect unmeasured confounds, environmental contaminants of the coal mining industry, or some combination thereof.

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Chronic Nasal Instillation of Residual-Oil Fly Ash (ROFA) Induces Brain Lipid Peroxidation and Behavioral Changes in Rats

Cited by 27 publications

References 32 publications

Air pollution: mechanisms of neuroinflammation and CNS disease

Air pollution: mechanisms of neuroinflammation and CNS disease

Brain DNA damage and behavioral changes after repeated intermittent acute ethanol withdrawal by young rats

Learning Outcomes among Students in Relation to West Virginia Coal Mining: an Environmental Riskscape Approach

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