Chronic Morphine Treatment Induces Hypersensitivity to Testosterone-Negative Feedback in Castrated Male Rats

Gabriel, Steven M.; Simpkins, James W.; Kalra, Satya P.; Kalra, Pushpa S.

doi:10.1159/000124049

Cited by 34 publications

(21 citation statements)

References 29 publications

(47 reference statements)

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“…Also, it may be due to decreased secretion of GnRH by the hypothalamus, or failure of the anterior pituitary to respond to GnRH stimulation. According to Carou et al [30], administration of camphor in rats caused slight reduction in levels of LH, FSH, and (GnRH) in vitro, while similar findings have also been reported in rats following morphine [31][32][33][34], and alcohol exposures [35,36].…”

Section: Discussionsupporting

confidence: 53%

Effect of edible camphor administrations on levels of steroid and thyroid hormones in male wistar rats

Somade¹,

Ugbaja²,

Adebayo³

2017

Am J Res Med Sci

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Background: Edible camphor (EC) is one of the ingredients in the preparation of local infusion for the management and treatment of pile, back pain, and erectile dysfunction, which are practices commonly in the south-western part of Nigeria. Conversely, 2 and 4 g/kg EC significantly increased the serum level of FT3 but was significantly reduced by 6 g/kg EC, and finally, EC administrations did not have any significant effect on serum PSA. Methods: Thirty rats were used for the study, and were divided into six groups of five rats each. Group I animals served as normal control, group II animals served as vehicle control and were orally administered 6 mL/kg corn oil, while groups III, IV, V, and VI animals were orally administered 1, 2, 4, and 6 g/kg EC for seven days. Results: Following EC administrations, there was significant (p < 0.05) decrease in serum total cholesterol (TCHOL) by 4 and 6 g/kg body weight EC. Furthermore, luteinizing hormone (LH), testosterone (TST), and thyroid stimulating hormone (TSH) levels were significantly reduced by the various doses. Conversely, 2 and 4 g/kg EC significantly increased the serum level of free triiodothyronine (fT3), but was significantly reduced by 6 g/kg EC, and lastly, EC administrations did not have any significant effect on serum prostate specific antigen (PSA). Conclusion:We therefore concluded that the use of EC should be with caution, and may contribute to thyroid and hormonal disruption in rats. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 53%

Effect of edible camphor administrations on levels of steroid and thyroid hormones in male wistar rats

Somade¹,

Ugbaja²,

Adebayo³

2017

Am J Res Med Sci

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“…Studies showed that morphine decreased LH and also testosterone secretion while morphine antagonists like Naltrexone and Naloxone relieved this effects, but after a chronic treatment, a high level of testosterone along with the fact that morphine enhanced sensitivity of the hypothalamus to negative feedback by testosterone could induce a negative effect on male reproductive system in morphine abused subject treated with Naloxone (4,5).…”

Section: Introductionmentioning

confidence: 99%

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Moradi¹,

Mahmoodi²,

Raoofi³

et al. 2015

BLL

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Abstract:Background: Knowledge about harmful effects of morphine on hormone secretion seems to be necessary. The aim of the present study was to evaluate the effect of pentoxifylline on side effects derived by morphine on hypophyso-gonadal hormones of male rats. Methods: 32 male rats were divided into the 4 groups of OSS: control (received 40 g Sucrose/l drinking water and intraperitoneal injection of 1 l/kg normal saline), OMS: morphine group (received 0.4 mg/l + 40 g Sucrose/l in drinking water and intraperitoneal injection of 1 l/kg normal saline), NMS: morphine+naltrexane group (received 0.4 mg/l + 40 g Sucrose/l in drinking water and IP injection dose of 10 mg/kg/ml/day Naltrexane) and PMS: morphine + pentoxifylline group (received 0.4 mg/dl + 40 g Sucrose/l in drinking water and IP injection dose of 12 mg/kg/ml/day Pentoxifylline) for 56 days, respectively. Results: Serum levels of testosterone, LH, FSH hormones were measured. Pentoxifylline increased serum levels of testosterone, LH, FSH hormones compared to control, morphine and morphine-naltrexane groups. Conclusion: Pentoxifylline has a signifi cant effi cacy for increasing serum levels of sexual hormones. Considering that Pentoxifylline is safe and cheap, with easy application, we suggest for the usage of this drug for improving semen parameter's quality before performing ART for the treatment of morphine addicts (Fig. 1, Ref. 31). Text in PDF www.elis.sk.

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“…The castra tion-induced decline in sexual activity is associated with in creased dopaminergic activity in the POA-AH. Testos terone and morphine each can decrease POA-AH dopa minergic activity, and yet, in contrast to this neurochemical effect and the synergistic effect of testosterone and mor phine on gonadotropin secretion in castrate male rats [27,28], testosterone and morphine exert opposite effects on co pulatory behavior. Finally, the decline in sexual activity seen in rats receiving chronic morphine appears to be due primarily to a decrement in sexual interest and not in erec tile ability.…”

Section: Discussionmentioning

confidence: 97%

Chronic Morphine and Testosterone Treatment

Clark¹,

Gabriel

Simpkins

et al. 1988

Neuroendocrinology

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The effects of sustained delivery of morphine and/or testosterone (T) on male rat copulatory behavior, penile reflexes and dopaminergic metabolism in selected brain regions were examined. Castration was followed by (1) a decrease in the number of male rats exhibiting intromissive and ejaculatory behavior in mating tests, (2) decreased erections in ex copula tests, and (3) increases in dopamine and dihydroxyphenylacetic acid (DOPAC) concentrations in the mediobasal hypothalamus (MBH) and the preoptic area-anterior hypothalamus (POA-AH). The decreased incidence of copulatory behavior and penile reflexes seen after castration was effectively prevented by a 4-day treatment with 5-mm T-containing Silastic capsules. Chronic morphine implants, conversely, accentuated the castration-induced decrements in copulatory behavior and prevented the 5-mm-T-induced facilitation, but did not alter the number of animals displaying erection (although the number of erections displayed by testosterone-treated rats was reduced) in ex copula tests. Treatment of castrated rats with 5 mm T, but not morphine alone, nor the combination of 5 mm T plus morphine, significantly reduced dopamine and DOPAC levels in the MBH. In the POA-AH, 5 mm T was without effect, whereas morphine, alone or in combination with 5 mm T, reduced the levels of dopamine and DOPAC. These data suggest that (1) the decline in sexual behavior induced by chronic morphine is primarily due to a failure of sexual arousal, and not of erectile ability, and (2) although the decline in sexual activity seen after castration is associated with alterations in dopaminergic metabolism, the effects of morphine and testosterone on sexual activity are opposite and dissociated from alterations in dopaminergic metabolism.

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Chronic Morphine Treatment Induces Hypersensitivity to Testosterone-Negative Feedback in Castrated Male Rats

Cited by 34 publications

References 29 publications

Effect of edible camphor administrations on levels of steroid and thyroid hormones in male wistar rats

Effect of edible camphor administrations on levels of steroid and thyroid hormones in male wistar rats

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Chronic Morphine and Testosterone Treatment

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