Chronic Lymphocytic Leukaemia/ Small-Cell Lymphocytic Lymphoma of the Lacrimal Sac: A Case Series

Krishna, Yamini; Irion, Luciane; Karim, Sozan; Dharmsena, Aruna; McCormick, Austin; Coupland, Sarah E.

doi:10.1159/000455148

Cited by 12 publications

(10 citation statements)

References 10 publications

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“…Enlargement of the lacrimal ducts and surrounding bone compression could also be observed. Though not as commonly as in epithelial malignancies, bony destruction could be observed in LSLs [25] . MRI is more helpful in the differential diagnosis of LSTs since MRI could provide better tumor definition and determination of the cystic or solid nature of the masses.…”

Section: Discussionmentioning

confidence: 89%

Lacrimal sac lymphoma: a case series and literature review

Meng¹,

Yuan²,

Zhang³

et al. 2022

Int J Ophthalmol

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AIM: To study the clinical and pathological characteristics of the lacrimal sac lymphoma, which is rare but it is the major type of non-epithelial malignant tumor in the lacrimal sac region. METHODS: Sixty-four cases of malignant lacrimal sac tumors in our hospital from 1986 to 2020 were retrospectively reviewed. Eight cases of lacrimal sac lymphoma were carefully reviewed. RESULTS: There were five mucosal-associated lymphoid tissue (MALT) lymphomas, one diffused large B-cell lymphoma, one NK/T cell lymphoma, and one mantle cell lymphoma. All eight patients represented symptoms of epiphora with swelling in the lacrimal sac for a certain period of time and showed no signs of systemic involvement at the first time of clinical visits. They had received either chemotherapy or radiotherapy after surgery. Long-term follow-up (from 11 to 220mo) showed that, except one patient with MALT lymphoma died for unknown reasons at 104mo after surgery, the other 7 patients were all alive with no signs of local recurrence, neither in other organs. CONCLUSION: Non-epithelial malignant tumors of the lacrimal sac are rare and lymphoma is the major subtype.

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Section: Discussionmentioning

confidence: 89%

Lacrimal sac lymphoma: a case series and literature review

Meng¹,

Yuan²,

Zhang³

et al. 2022

Int J Ophthalmol

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“…They present with symptoms of dacryocystitis and epiphora. There are reports which describe 3 lacrimal sac Leukaemia/Small-Cell Lymphocytic Lymphoma cases [19]. Some authors found only 3 cases of adenocarcinoma among 74 malignant lacrimal sac tumors, and others reported 4 adenocarcinomas among 115 lacrimal sac neoplasms [5,6].…”

Section: Discussionmentioning

confidence: 99%

Acquired Nasolacrimal Duct Obstruction: Clinical and Histological Findings of 275 Cases

Makselis

Petroška

Kadziauskiene

et al. 2021

Preprint

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Background: Acquired nasolacrimal duct obstruction is a blockage of the lacrimal outflow system usually caused by a local non-specific inflammation of the lacrimal sac and the nasolacrimal duct. However, cases exist where the primary nasolacrimal system obstruction was caused by malignancies. Our aim was to investigate lacrimal sac pathologies in patients with acquired nasolacrimal duct obstruction and compare its clinical manifestations. Methods: The retrospective clinical study included 275 cases with acquired nasolacrimal duct obstruction who underwent external dacryocystorhinostomy and lacrimal sac biopsy. Cases were classified into tumor or non-specific pathology groups subdivided according to the level of inflammation. Histological and clinical data were analyzed.Results: Three tumors (1.1%) (adenoid cystic carcinoma, eccrine spiradenoma and small B cell lymphoma) were diagnosed. Chronic non-granulomatous inflammation was the most common histological finding, corresponding to 194 cases (70.5%). Other 81 (29.5%) were subacute, chronic forms of non-granulomatous inflammation, tumor and fibrosis cases. Epiphora with continuous purulent discharge was the most common clinical sign reported by 144 (52.4%) patients, two (0.7%) patients had a palpable mass near the medial canthal tendon, which were identified as an eccrine spiradenoma and small B cell lymphoma. There was no significant difference in the clinical symptoms, its’ duration or case history between the non-specific pathology and the tumor groups (p = 0.292). Conclusions: Chronic non-granulomatous inflammation of the lacrimal sac was the most frequent etiology of acquired nasolacrimal duct obstruction. There were no associations between the histological findings and clinical presentation. The authors recommend a lacrimal sac biopsy only in cases when a tumor is clinically suspected.

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“…TA is an uncommon lesion, with a prevalence of 0.056 to 0.03 in every 1000 births, described as a single arterial stem emerging from the heart, which in turn gives rise to the pulmonary trunk in various ways. [4][5][6][7][8] TA belongs to the group of ectomesenchymal tissue migration anomalies caused by the aberrant migration of neural crest cells through the branchial arch vessels during cardiogenesis. 9,10 Chromosomal abnormalities are detectable in 8.7% of cases of TA.…”

Section: Discussionmentioning

confidence: 99%

Favorable Postoperative Evolution after Late Surgical Repair of Truncus Arteriosus Type 1: A Case Report

Toma

Şuteu

Togănel

2018

Journal of Interdisciplinary Medicine

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Truncus arteriosus communis (TA) is a rare cyanotic congenital heart defect, in which the aorta and the pulmonary artery have not been separated during the normal development of the fetal heart, so a single truncal artery is arising from the base of the heart. Most patients with TA present within the first weeks of life with heart failure. This anomaly is an important cause of pulmonary arterial hypertension. Corrective surgery is indicated in the first 3 months of life, to avoid the development of severe pulmonary arterial hypertension. We report the case of a 12-month-old male infant diagnosed by echocardiography with truncus arteriosus type 1 in whom, based on hemodynamic data, surgical treatment could be performed at the age of 1 year.

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Chronic Lymphocytic Leukaemia/ Small-Cell Lymphocytic Lymphoma of the Lacrimal Sac: A Case Series

Cited by 12 publications

References 10 publications

Lacrimal sac lymphoma: a case series and literature review

Lacrimal sac lymphoma: a case series and literature review

Acquired Nasolacrimal Duct Obstruction: Clinical and Histological Findings of 275 Cases

Favorable Postoperative Evolution after Late Surgical Repair of Truncus Arteriosus Type 1: A Case Report

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