Lacrimal sac lymphoma: a case series and literature review

Abstract

AIM: To study the clinical and pathological characteristics of the lacrimal sac lymphoma, which is rare but it is the major type of non-epithelial malignant tumor in the lacrimal sac region. METHODS: Sixty-four cases of malignant lacrimal sac tumors in our hospital from 1986 to 2020 were retrospectively reviewed. Eight cases of lacrimal sac lymphoma were carefully reviewed. RESULTS: There were five mucosal-associated lymphoid tissue (MALT) lymphomas, one diffused large B-cell lymphoma, one NK/T cell lymphoma, and one mantle cell lymphoma. All eight patients represented symptoms of epiphora with swelling in the lacrimal sac for a certain period of time and showed no signs of systemic involvement at the first time of clinical visits. They had received either chemotherapy or radiotherapy after surgery. Long-term follow-up (from 11 to 220mo) showed that, except one patient with MALT lymphoma died for unknown reasons at 104mo after surgery, the other 7 patients were all alive with no signs of local recurrence, neither in other organs. CONCLUSION: Non-epithelial malignant tumors of the lacrimal sac are rare and lymphoma is the major subtype.

Primary lacrimal sac lymphoma: a case-based retrospective study in a Chinese population

“…But some other results have been reported. Meng et al [9] retrospectively analyzed 8 Chinese patients with primary dacryocystoid lymphomas, including five MALT lymphoma, one DLBCL, one NK/T-cell lymphoma, and one mantle cell lymphoma. Although Singh and Ali [4] found more reports of primary than secondary lacrimal sac lymphoma, there could have been a possible publication bias.…”

“…Although lymphoma patients typically have systemic symptoms, lacrimal sac lymphoma manifests as an isolated ocular appendage lesion [5] . Primary lacrimal sac lymphoma refers to a lesion that originates from the lacrimal sac without systemic lesions, or the early stage of disease when there is no systemic disease [5] Previous studies have characterized populations with lacrimal sac lymphoma in Europe [5] , the United States [8] , Japan [7] , and China [9] . No literature has been found to assess tumor markers Int J Ophthalmol, Vol.…”

Predicting the prognosis of primary orbital lymphoma by clinical characteristics and imaging features

“…Taking into consideration the findings of this study, the previous literature, and the poor treatment effects of only surgery for lymphoma, the treatment methods in this study were categorized into 4 groups, i.e., only surgery group, radiotherapy or surgery + radiotherapy group, chemotherapy or surgery + chemotherapy group, and chemoradiotherapy or surgery + chemoradiotherapy group. DISCUSSION B-cell lymphoma is the dominant primary orbital lymphoma type, accounting for more than 90% of all primary orbital lymphomas [1][2][3][6][7] . In the present study, there were 70 patients with B-cell lymphoma, accounting for 97.2% of all tumors.…”

“…L ymphomas involving orbit include primary and secondary lymphomas, where the former refer to pathologically proven orbital lymphoma that is not accompanied by lymphoma of other sites or with no history of lymphoma before orbit involvement. Primary orbit lymphoma rarely occurs, accounting for approximately 5%-10% of all extranodal lymphomas [1][2] . Non-Hodgkin's lymphoma is the major pathological subtype of primary orbital lymphoma, whose dominant type is B-cell lymphoma [1][2][3][4] .…”

“…Primary orbit lymphoma rarely occurs, accounting for approximately 5%-10% of all extranodal lymphomas [1][2] . Non-Hodgkin's lymphoma is the major pathological subtype of primary orbital lymphoma, whose dominant type is B-cell lymphoma [1][2][3][4] . In recent years, primary orbital lymphoma has gradually increased, especially in people with immunosuppression or immune hyperfunction, and early diagnosis and standard treatments are major factors influencing the outcomes of those patients [3] .…”