Chronic liver and renal diseases differently affect structure of human serum albumin

Ivanov, Andrei I.; Korolenko, E. A.; Королик, Е. В.; Firsov, S. P.; Zhbankov, R. G.; Marchewka, M.K.; Ratajczak, H.

doi:10.1016/s0003-9861(02)00533-7

Cited by 45 publications

(35 citation statements)

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“…[28] It is well known that human serum albumin (HSA) is a principal extracellular transport protein, present in a high concentration (∼40 mg/ml) in blood plasma. [29] This protein is a globular molecule which contains 17 disulfide bridges that produce Raman bands in the region of S-S stretching vibration at 480-600 cm −1 . [29,30] The band located at ∼577 cm −1 is assigned to the trans-gauche-trans (tgt) configurations of disulfide bridges.…”

Section: Raman and Sers Spectra Of Hsmentioning

confidence: 99%

“…[29] This protein is a globular molecule which contains 17 disulfide bridges that produce Raman bands in the region of S-S stretching vibration at 480-600 cm −1 . [29,30] The band located at ∼577 cm −1 is assigned to the trans-gauche-trans (tgt) configurations of disulfide bridges. [31] Meanwhile, HSA is known to be rich in α-helix structure, which can be confirmed by a Raman band due to the amide I at ∼1660 cm −1 [32] (Fig.…”

Section: Raman and Sers Spectra Of Hsmentioning

confidence: 99%

“…Meanwhile, the Raman Amide I band of HSA was also characterized by another weaker component at ∼1615 cm −1 . [29] The Fermi-resonance band of tyrosine (Tyr) doublet was present at 800-860 cm −1 ; [29] in addition, the 880 cm −1 Raman bands are also responsible for Tyr vibration. The 1326 cm −1 band is the microenvironment-sensitive region of tryptophan (Trp) vibration, [33] and the band at 1440 cm −1 is also assigned to Trp vibration of proteins in HS.…”

Section: Raman and Sers Spectra Of Hsmentioning

confidence: 99%

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Surface‐enhanced Raman scattering study of human serum on PVAAg nanofilm prepared by using electrostatic self‐assembly

Liu

Xing-fa

Kang

et al. 2011

J Raman Spectroscopy

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Polyvinyl alcohol (PVA)-protected silver nanoarchitecture (PVA-Ag nanofilm) on the surface of the glass substrate was prepared by using electrostatic self-assembly at a proper voltage. The two-dimensional morphology of the PVA-Ag nanofilm has been examined by scanning electron microscopy (SEM). The surface-enhanced Raman scattering (SERS) spectra of human serum (HS) on PVA-Ag nanofilms were recorded. The results show that the Raman scattering of HS can be enhanced efficiently based on these PVA-Ag nanofilms. However, it also can be seen that the effect of sodium citrate (SC) acting as anticoagulant on the SERS spectrum of HS is unnegligible, which has not been discussed adequately in the previous reports. To discuss the effect of SC on the SERS spectrum of HS, we have studied the normal Raman spectra of solid SC and the SERS spectra of 1.0×10 −3 mol/l aqueous solution of SC adsorbed on the PVA-Ag nanofilms. Meanwhile, Raman wavenumbers of the SC molecule were calculated by using the method of DFT-B3LYP/6-31G * , and the dominant assignations of the calculated wavenumbers were performed. It was found that the density functional theory (DFT) calculation of SC Raman spectrum matches well with the experimental results. With the perfect reproducibility and high SERS activity, this method will be useful in the development of HS detection methods.

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Section: Raman and Sers Spectra Of Hsmentioning

confidence: 99%

Section: Raman and Sers Spectra Of Hsmentioning

confidence: 99%

Section: Raman and Sers Spectra Of Hsmentioning

confidence: 99%

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Surface‐enhanced Raman scattering study of human serum on PVAAg nanofilm prepared by using electrostatic self‐assembly

Liu

Xing-fa

Kang

et al. 2011

J Raman Spectroscopy

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“…14,15 Patients with chronic liver disease tend to have lower serum albumin, and it has been suggested that conformational changes in the molecule and may cause diminished binding ability and a change in body distribution of albumin. 21 Impaired renal function with advanced liver disease and hemorrhagic risk is a multifactorial relationship. Chronic hepatitis is associated with glomerulonephritis, albuminuria, and progression of existing renal disease, as well as places patients at risk for acute kidney injury because of physiological changes that affect the circulation and kidney perfusion, 22 and hepatorenal syndrome is a complication of advanced liver disease.…”

Section: Discussionmentioning

confidence: 99%

Stratifying the Risks of Oral Anticoagulation in Patients With Liver Disease

Efird

Mishkin

Berlowitz

et al. 2014

Circ: Cardiovascular Quality and Outcomes

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Background— Chronic liver disease presents a relative contraindication to warfarin therapy, but some patients with liver disease nevertheless require long-term anticoagulation. The goal is to identify which patients with liver disease might safely receive warfarin. Methods and Results— Among 102 134 patients who received warfarin from the Veterans Affairs from 2007 to 2008, International Classification of Diseases -Ninth Revision codes identified 1763 patients with chronic liver disease. Specific diagnoses and laboratory values (albumin, aspartate aminotransferase, alanine aminotransferase, creatinine, and cholesterol) were examined to identify risk of adverse outcomes, while controlling for available bleeding risk factors. Outcomes included percent time in therapeutic range, a measure of anticoagulation control, and major hemorrhagic events, by International Classification of Diseases -Ninth Revision codes. Patients with liver disease had lower mean time in therapeutic range (53.5%) when compared with patients without (61.7%; P <0.001) and more hemorrhages (hazard ratio, 2.02; P <0.001). Among patients with liver disease, serum albumin and creatinine levels were the strongest predictors of both outcomes. We created a 4-point score system: patients received 1 point each for albumin (2.5–3.49 g/dL) or creatinine (1.01–1.99 mg/dL), and 2 points each for albumin (<2.5 g/dL) or creatinine (≥2 mg/dL). This score predicted both anticoagulation control and hemorrhage. When compared with patients without liver disease, those with a score of zero had modestly lower time in therapeutic range (56.7%) and no increase in hemorrhages (hazard ratio, 1.16; P =0.59), whereas those with the worst score (4) had poor control (29.4%) and high hazard of hemorrhage (hazard ratio, 8.53; P <0.001). Conclusions— Patients with liver disease receiving warfarin have poorer anticoagulation control and more hemorrhages. A simple 4-point scoring system using albumin and creatinine identifies those at risk for poor outcomes.

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“…Спектр исследований, помимо общепринятых тестов, включал определение эффективной концентрации альбумина (ЭКА) [4], кроме того, спектр маркеров интоксикации был рас ширен за счет исследований концентраций среднемолекуляр ных пептидов (СМП), β 2 микроглобулина (β 2 МГ) [5] и ин тактного паратиреоидного гормона (иПТГ).…”

Section: материал и методыunclassified

The Elimination of Low-Molecular-Weight Proteins in Patients with Isolated Acute Renal Failure

Ямпольский¹,

Заболотских²,

Ямпольский³

2010

rmt

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Изолированная острая почечная недостаточность (иОПН) незаслуженно обделена вниманием исследова телей, как в России, так и за рубежом. Обычно рассмат ривается острая почечная недостаточность в составе по лиорганной недостаточности или сепсиса, что приводит к некорректному анализу тяжести состояния больных с различными группами осложнений и не позволяет вы членить необходимые данные для разработки комплек са лечебных мероприятий, их эффективности, структу ры летальности [1]. Изолированная острая почечная не достаточность может быть результатом первичного воз действия, в результате которого, в основном, возникло почечное повреждение, в то время как другие органы не были значительно вовлечены в патологический про цесс. Другой группой обычно являются пациенты с раз вившимися осложнениями уже на поздних этапах лече ния иОПН и трансформацией иОПН в синдром ПОН, но этот период в лечении больного реально существо вал и, возможно, именно отсутствие точных представле ний о характере лечения и привело к развитию цепи ос ложнений. Последняя группа больных -это пациенты с изначально развившейся ПОН, по истечении некото рого периода времени регрессировавшей в иОПН. В то Objective: to study the effectiveness of some types of semipermeable dialysis membranes and replacement therapy tech niques in patients with isolated acute renal failure (iARF). Subjects and methods: Eighty nine patients aged 24 to 67 years, who received intensive and replacement/maintenance therapy, were examined. The patients were divided into 3 groups in accordance with their condition rated by the APACHE III scale, from the used dialysis membranes and renal replace ment/maintenance therapy options. Results. By varying the permeability of a membrane, its area and the volume of convec tion, we can control the rate of substance elimination, which is similar to that of test markers having a molecular weight of 100 to 15000 Da. Conclusion. Adequate replacement therapy for iARF is possible only when high flux, high permeability dia lyzers are applied. The indices of hemodialysis/hemodiafiltration adequacy in terms of urea cannot be determinants in patients with iARF. The achievement of elimination of low molecular weight proteins -markers of uremic intoxication to 30-35% and/or an increase in effective albumin concentrations as a summary marker of toxicity by 16-20% is of much more importance.

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Chronic liver and renal diseases differently affect structure of human serum albumin

Cited by 45 publications

References 46 publications

Surface‐enhanced Raman scattering study of human serum on PVAAg nanofilm prepared by using electrostatic self‐assembly

Surface‐enhanced Raman scattering study of human serum on PVAAg nanofilm prepared by using electrostatic self‐assembly

Stratifying the Risks of Oral Anticoagulation in Patients With Liver Disease

The Elimination of Low-Molecular-Weight Proteins in Patients with Isolated Acute Renal Failure

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