Chronic leukemias

Morrison, Vicki A.

doi:10.3322/canjclin.44.6.353

Cited by 15 publications

(6 citation statements)

References 83 publications

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“…CML is a clonal hematopoietic disorder due to an acquired genetic defect in the pluripotential stem cell population. CML accounts for 6 to 15 percent of adult leukemia cases, and has an incidence of 1 to 1.5 per 100,000 per year [17]. CML usually behaves as a biphasic illness.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous spinal epidural hematoma as the initial presentation of leukemia

Nojiri¹,

Kim²,

Tsuji

et al. 2009

Eur Spine J

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We present a case of a 55-year-old male with progressive neurological deficits that appeared dramatically. MRI detected a spinal epidural hematoma at the cervicothoracic junction and blood tests showed leukocytosis, mild anemia, and thrombocytosis. Spontaneous spinal epidural hematoma (SSEH) as the initial presentation of leukemia was diagnosed. Urgent posterior decompression was performed after 28 h from acute onset of backache, and the patient experienced remarkable improvement in neurological findings.

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Section: Discussionmentioning

confidence: 99%

Spontaneous spinal epidural hematoma as the initial presentation of leukemia

Nojiri¹,

Kim²,

Tsuji

et al. 2009

Eur Spine J

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“…The third phase is also known as blast crisis. In blast crisis or phase the peripheral blood is rich in blast cells and immature cells proliferate [6]. More than three fourth of the Patients are diagnosed in chronic phase only.…”

Section: Myeloid Leukemia Vis-a-vis Raktapittamentioning

confidence: 99%

“…This changes the biochemic profile of blood. Blood examination reveals the presence of immature precursors, granulocytes, blast cells, etc [6]. these changes alters the viscosity of blood thus results in hyperviscosity condition.…”

Section: Introductionmentioning

confidence: 99%

Myelo Proliferative Disorder (Myeloid Leukemia) Vis-à-Vis Triyak Raktapitta and its Ayurvedic Management – A Clinico –Theoretical Review

Shukla¹

2012

JCST

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“…It accounts for about 7-15% of all leukemias. 1 Males are more commonly affected than female (14:1). 2 The Philadelphia (ph) chromosome in the malignant cells is found in more than 90% of patients with CML.…”

Section: Introductionmentioning

confidence: 99%

Effect of Chemotherapy on Philadelphia Chromosome in Chronic Myeloid Leukemia (Cml) Patients

2003

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Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder as a resultof neoplastic transformation of the primitive hemopoetic cells. It is well known thatthe Philadelphia chormosome (ph) is a specific abnormality found in 90% of CMLpatients. It has been reported that interferon has better effect on disease control andprognosis. Cytogenetic analysis of ph chromosome plays very important role in theprognosis and monitoring of therapy. In this present study 35 diagnosed patients ofCML were considered, which included untreated patients of various age groups (2-62yrs). The cases were refered from haematology clinic of All India Institute of MedicalSciences (AIIMS). Out of 35 patients only 13 patients were available after six monthof therapy for follow-up cytogenetic analysis. Out of 13 patient, 2 were ph negative, 8were 100% ph positive and 3 were ph positive mosaic before therapy. Of the 3 mosaicpatients, 2 remained unchanged after therapy and one patient became 100% phnegative. Though in general significant reduction in ph% by interferon therapy wasseen but minority patients showed complete cytogenetic remissionKey Words: Chronic myeloid leukemia, chemotherapy, Philadelphia chromosome.

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Chronic leukemias

Cited by 15 publications

References 83 publications

Spontaneous spinal epidural hematoma as the initial presentation of leukemia

Spontaneous spinal epidural hematoma as the initial presentation of leukemia

Myelo Proliferative Disorder (Myeloid Leukemia) Vis-à-Vis Triyak Raktapitta and its Ayurvedic Management – A Clinico –Theoretical Review

Effect of Chemotherapy on Philadelphia Chromosome in Chronic Myeloid Leukemia (Cml) Patients

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