Spontaneous spinal epidural hematoma as the initial presentation of leukemia

Nojiri, Hidetoshi; Kim, Sung-Do; Tsuji, Takaaki; Uta, Soichi

doi:10.1007/s00586-008-0863-y

Cited by 14 publications

(9 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 It is usually isointense on T1-weighted and hyperintense on T2-weighted MRI in the first 24 hours following symptom onset, and hyperintense on both T1-weighted and T2-weighted MRI after 24 hours. 1,13,[24][25][26] Enhanced MRI is not essential but may help exclude other epidural lesions. Spinal CT scans, especially three-dimensional CT scans, can also be useful where MRI is contradicted or unavailable.…”

Section: Discussionmentioning

confidence: 98%

Spontaneous spinal epidural hematoma

Zhong

Chen

You

et al. 2011

Journal of Clinical Neuroscience

103

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

Spontaneous spinal epidural hematoma

Zhong

Chen

You

et al. 2011

Journal of Clinical Neuroscience

103

View full text Add to dashboard Cite

“…Chronic myeloid leukemia has been reported rarely as a cause of spontaneous hematoma in various sites, i.e., chest wall [ 12 ], soft tissue [ 13 ], retroperitoneal spontaneous iliac psoas muscle [ 14 ], mediastinal hematoma and hemothorax [ 15 ], spontaneous epidural hematoma [ 16 ], and following bone marrow biopsy [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Antiplatelet Therapy and Spontaneous Retroperitoneal Hematoma: A Case Report and Literature Review

et al. 2017

View full text Add to dashboard Cite

Patient: Male, 66Final Diagnosis: Spontaneous retroperitoneal hematoma seconday dual antiplatelet therapySymptoms: Anemia • knee joint painMedication: —Clinical Procedure: NoneSpecialty: CardiologyObjective:Rare diseaseBackground:Dual antiplatelet therapy has proven efficacy in primary and secondary prevention of coronary artery disease with a relatively good safety profile. Review of the literature revealed 8 cases of spontaneous retroperitoneal hematoma secondary to antiplatelet treatment.Case Report:We report the case of a 66-year-old male with a flare of acute gout secondary to uncontrolled chronic myeloid leukemia. The patient was started on dual antiplatelet treatment following a drug-eluted stent placement for symptomatic coronary artery disease. He suffered from an unexplained acute drop of five grams of hemoglobin from 10.4 to 5.8 g/dL and symptomatic anemia. The initial labs excluded occult GI bleeding, hemolysis, and bone marrow suppression. However, an abdominal CT scan showed an approximately 7.2×4.7×6.7 cm spontaneous retroperitoneal hematoma involving the left iliacus muscle. The patient was successfully treated conservatively by discontinuing antiplatelet therapy and supportive measures.Conclusions:A spontaneous retroperitoneal hematoma often presents without localizing signs and symptoms and therefore should be considered in any case of unexplained blood loss in patients on antiplatelet therapy. CT without contrast is the modality of choice to diagnose retroperitoneal hematoma.

show abstract

“…Three of the patients had a haematological malignancy. Two had chronic myelogenous leukaemia with elevated immature white cell and platelet counts [3,5] and the other had multiple myeloma in the spine with normal blood parameters but had received prophylactic low molecular weight heparin prior to onset of haematoma [2]. The authors suspected that the tumour may have caused epidural inflammation and epidural venous plexus fragility resulting in the haematoma.…”

Section: Spontaneous Spinal Epidural Haematomamentioning

confidence: 98%

“…Malignancy as a cause has only been described four times before [2][3][4][5]. Three of the patients had a haematological malignancy.…”

Section: Spontaneous Spinal Epidural Haematomamentioning

confidence: 99%

“…A number of potential causes for SSEH have been identified including anticoagulant and antiplatelet use, bleeding diatheses, vascular malformations and hypertension but there have only been four previously described cases where an underlying malignancy has been responsible [2][3][4][5]. Three of those cases were haematological malignancies, the fourth metastatic bronchial adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Metastatic thymoma presenting as spontaneous epidural lumbar haematoma

2015

View full text Add to dashboard Cite

We report the case of a 44-year-old man who was found to have metastatic thymoma to his lumbar spine presenting as a spontaneous epidural haematoma. The man presented with back pain and cauda equina like symptoms in the absence of trauma, antiplatelet or anticoagulant agents. Following a laminectomy and excision of the epidural collection he made a full neurological recovery. Histopathology of the haematoma demonstrated metastatic thymoma. To the best of our knowledge, this is the first such case of metastatic thymoma to the lumbar spine presenting as a spontaneous epidural collection. We believe, in all patients with spontaneous spinal epidural haematoma and a background of malignancy, histopathological analysis should be sought.

show abstract

Spontaneous spinal epidural hematoma as the initial presentation of leukemia

Cited by 14 publications

References 18 publications

Spontaneous spinal epidural hematoma

Spontaneous spinal epidural hematoma

Antiplatelet Therapy and Spontaneous Retroperitoneal Hematoma: A Case Report and Literature Review

Metastatic thymoma presenting as spontaneous epidural lumbar haematoma

Contact Info

Product

Resources

About