Chronic leg ulcers in sickle cell disease patients in Zaria, Nigeria

Hassan, Abdulaziz; Dogara, Livingstone Gayus; Ibrahim, Abdulrasheed; Musa, A.A.; Ismail, Dahiru L; Babadoko, Ahmadu Aliyu

doi:10.4103/2278-9596.146405

Cited by 14 publications

(27 citation statements)

References 2 publications

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“…4 It is a common manifestation of SCD in Nigeria with a reported prevalence of 1.7% to 29.4%. [15][16][17][18] Leg ulcers are said to be more common in men with a male-to-female ratio of 1.3:1, 17 which is exactly what was obtained in this study.…”

Section: Discussionsupporting

confidence: 88%

“…28 Although platelet count was higher in SWLU than SNLU, it was not statistically significant. Similarly, sP-selectin, which is a marker of platelet activation with increased expression in patients with SCD, 17 was also slightly higher in SWLU than in Table 4. Multiple regression of the statistically significant values in Table 3 CFA SNLU, but this was also not statistically significant.…”

Section: Discussionmentioning

confidence: 83%

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Intima-media thickness of the common femoral artery as a marker of leg ulceration in sickle cell disease patients

Ayoola

Bolarinwa²,

Onakpoya³

et al. 2018

Blood Advances

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Leg ulceration is a debilitating chronic complication of sickle cell disease (SCD) the pathogenesis of which is yet to be fully elucidated. We hypothesized that SCD patients with histories of previous leg ulcers would have intima hyperplasia of the common femoral artery (CFA). We enrolled 44 SCD patients and 33 age-matched and sex-matched controls with hemoglobin AA. Anthropometric measurements, biochemical parameters, and sonographic intima-media thickness (IMT) of the CFA were determined. The median CFA IMT in SCD limbs with history of leg ulcers (SWLU) was 1.0 mm, whereas it was 0.7 mm in SCD limbs with no history of leg ulcer (SNLU) and 0.60 mm in controls (P < .001). Among the SNLU, 70.3% had CFA IMT <0.9 mm, whereas only 29.7% had CFA IMT ≥0.9 mm. Conversely, only 20.8% of SWLU had CFA IMT <0.9 mm, whereas the remaining 79.2% had CFA IMT ≥0.9 mm. All the controls had CFA IMT <0.9 mm. Binary logistic regression to determine the odds of having leg ulcer among SCD limbs with CFA IMT of ≥0.9 mm yielded an odds ratio of 9, indicating that SCD limbs with CFA IMT ≥0.9 mm had a 9 times greater risk of having leg ulcer compared with those with CFA IMT <0.9 mm. There is a significant increase in the CFA IMT of SCD limbs with ulcer compared with controls and SCD limbs without ulcer, suggesting that arterial vasculopathy plays a major role in the formation of these ulcers.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 83%

Intima-media thickness of the common femoral artery as a marker of leg ulceration in sickle cell disease patients

Ayoola

Bolarinwa²,

Onakpoya³

et al. 2018

Blood Advances

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“…Nolan et al 14 and Hassan et al 18 found that patients with leg ulcers had higher WBCs as is the case in this study. The majority of the patients with leg ulcers had elevated WBC counts at the beginning of the study.…”

Section: Discussionsupporting

confidence: 79%

Haematological indices of sickle cell patients with chronic leg ulcers on compression therapy

Babalola

Ogunkeyede

Odetunde

et al. 2020

African Journal of Laboratory Medicine

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Background Recurrent chronic leg ulcers and its are morbidities associated with sickle cell anaemia (SCA). Compression therapy increases the rate of healing of these ulcers and also decreases the rate of recurrence. Objective This study evaluated the haematological parameters of patients with SCA and chronic leg ulcers placed on high compression bandaging to provide data for improved ulcer management and prevention. Methods Eighteen patients with SCA and chronic leg ulcers were recruited for treatment by compression therapy in Ibadan, Nigeria, from March to June 2015. Eighteen SCA patients with no history of chronic leg ulcers were age and sex matched and recruited as controls. Blood samples, wound biopsies and swabs were collected at different time points for full blood count, microbiology, culture and antimicrobial susceptibility tests. Haemoglobin variants were quantified by high performance liquid chromatography. Fasting blood sugar was tested for leg ulcer patients to determine diabetic status. Results Ulcers ranged from 0.5 cm 2 to 416 cm 2 (median: 38.4 cm 2 ). Post-intervention ulcer size ranged from 0.0 cm 2 to 272 cm 2 (median: 18.6 cm 2 , p < 0.001); four ulcers completely healed. Compared to the control group, haematological indices at commencement of treatment were more severe in leg ulcer patients ( p = 0.02). No patients with chronic leg ulcer was diabetic. Microorganisms isolated from the leg ulcers include Pseudomonas aeruginosa, Staphylococcus aureus, Proteus sp., Escherichia coli and Klebsiella oxytoca . Conclusion Measures to improve haematological parameters during leg ulcer treatment in SCA patients should be taken to aid wound healing.

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“…The prevalence and incidence of leg ulcers varies geographically, with age and with the type of disease 6 . The results of a study carried out in Nigeria portrayed these variations and found an incidence of 0.45% and a prevalence of 3.1% 7 .…”

Section: Perfil De Mujeres Con úLcera De La Pierna Consecuente De Enfmentioning

confidence: 97%

Profile of Women With Leg Ulcers Due to Sickle Cell Disease

Andrade

Spira

Borges

et al. 2021

ESTIMA, Braz. J. Enterostomal Ther.

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Objective: to characterize the profile of women with leg ulcers resulting from sickle cell disease treated at a public health institution in Brazil. Method: historical cohort study conducted in the outpatient sector with a sample of women with sickle cell disease and leg ulcer, followed from 1998 to 2014. The data were extracted from the medical record and included sociodemographic, clinical and ulcer-related variables, and underwent descriptive statistical analysis. Results: of the 17 women, 64.7% were cured, 58.8% were aged between 30 and 39 years, 64.7% declared themselves brown, 70.6% were without partners, 41.2% had incomplete elementary education, 52, 9% had an income of 2 to 3 minimum wages, 70.6% were eutrophic and 82.4% used vitamin supplements. Women had a total of 29 ulcers, 52.9% had a single ulcer, 41.4% were located in the malleolar region, 55.17% were between 2 and 36 months, all classified as stage 3. The treatment was with coverings and Unna’s boot. Conclusion: the women received care from specialist nurses and most were cured with up to eight months of follow-up, which required a nursing consultation, including clinical evaluation, topical treatment and application of compression therapy.

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Chronic leg ulcers in sickle cell disease patients in Zaria, Nigeria

Cited by 14 publications

References 2 publications

Intima-media thickness of the common femoral artery as a marker of leg ulceration in sickle cell disease patients

Intima-media thickness of the common femoral artery as a marker of leg ulceration in sickle cell disease patients

Haematological indices of sickle cell patients with chronic leg ulcers on compression therapy

Profile of Women With Leg Ulcers Due to Sickle Cell Disease

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