Chronic lead intoxication affects glial and neural systems and induces hypoactivity in adult rat

Elucidation of mechanisms underlying the protective effects of olive leaf extract against lead-induced neurotoxicity in Wistar rats

“…Moreover studies have shown that rats exposed to low levels of Pb during the first postnatal month have deficits in memory and long-term potentiation that persist in the adult age (Murphy and Regan, 1999). Finally, several studies indicate that Pb affects the activity of the monoaminergic system during development of the CNS (Devi et al, 2005, Sansar et al, 2011. In one hand, some evidence indicates that Pb affects monoamine levels in the brain including serotonin (Leret et al, 2002), which is widely distributed throughout the brain and, in particular, in regions associated with anxiety (Linthorst, 2005).…”

Changes in rat urinary porphyrin profiles predict the magnitude of the neurotoxic effects induced by a mixture of lead, arsenic and manganese

“…While each one of the tested metals, Pb, As and Mn, may trigger neurotoxicity via diverse mechanisms (Halatek et al, 2009;Health Canada, Water, Air & Climate Change Bureau, 2008;Sansar et al, 2011), all are known to affect heme synthesis, which per se has been associated with neurotoxicity (Kauppinen, 2005). Accordingly, we explored whether combinations of changes in urinary porphyrin levels may predict the severity of neurotoxic effects induced by metal-mixture exposure.…”

“…Even low Pb levels (Sansar et al, 2011) induce cognitive and behavioral disorders (Patrick, 2006;Reddy et al, 2003), as well as motor deficits (Reckziegel et al, 2011). Chronic neurotoxic effects of As include memory, cognition and personality alterations, along with motor dysfunction (Dhatrak and Nandi, 2009;Halatek et al, 2009).…”

Lead Exposure and Environmental Health

“…Lead is described as a classic chronic toxin (Sansar et al, 2011). Few adverse health effects are observed following acute exposure to relatively low levels.…”