Chronic kidney disease–mineral bone disorder: an update on the pathology and cranial manifestations

Raubenheimer, Erich J.; Noffke, C E E; Hendrik, Hilde D.

doi:10.1111/jop.12176

Cited by 12 publications

(9 citation statements)

References 20 publications

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“…The ESRD patient also presents an immunodeficient state caused by altered cellular immunity associated with malnutrition, susceptibility to bacterial infection, and a diminished ability to produce antibodies [ 14 ].…”

Section: Esrd and Dialysismentioning

confidence: 99%

Dental Care for Patients with End-Stage Renal Disease and Undergoing Hemodialysis

Costantinides

Castronovo

Vettori

et al. 2018

International Journal of Dentistry

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Chronic renal failure is a progressive disease characterized by a gradual destruction of nephrons and a consequent reduction of kidney function. End-stage renal disease (ESRD) necessitates renal replacement therapy as peritoneal dialysis, hemodialysis, or transplantation. Patients affected by ESRD or in hemodialysis are at risk for developing a number of comorbidities including hypertension, anemia, risk of bleeding, susceptibility to infection, medication side effects, and oral manifestations associated with the disease itself and with hemodialysis treatment. In this context, oral diseases represent a potential and preventable cause of poor health outcomes in people with ESRD due to their relation to infection, inflammation, and malnutrition. The aim of this article was to review ESRD and hemodialysis-associated manifestations and to describe the dental operative protocols for patients awaiting kidney transplantation in light of the most recent literature.

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Section: Esrd and Dialysismentioning

confidence: 99%

Dental Care for Patients with End-Stage Renal Disease and Undergoing Hemodialysis

Costantinides

Castronovo

Vettori

et al. 2018

International Journal of Dentistry

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“…Therapy may be conservative (e.g., pharmacological or fluid restrictions and changes in the diet) or more aggressive, including dialysis and kidney transplantation. 3 In the last few years, great interest in the literature has been directed to the treatment of patients suffering from CRF and the oral manifestations of renal diseases. Increases in kidney transplantation and chronic long-term therapy in these patients have resulted in more frequent requests for dental therapies.…”

Section: Introductionmentioning

confidence: 99%

Oral manifestations in chronic uremia patients

et al. 2015

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The incidence of chronic renal failure (CRF) is approximately 200 cases per million people in different Western countries. Recent data indicate that the incidences of these pathologies are increasing. Ninety percent of patients with CRF report oral signs and symptoms that affect both the bone and soft tissues. A broad range of lesions may be observed in chronic uratemia patients, including the following: gingival hyperplasia, enamel hypoplasia, petechiae, gingival bleeding, and others lesions. These patients require various types of treatment ranging from dietary and lifestyle changes to dialysis and kidney transplantation. CRF often leads to multiple oral manifestations that are difficult for dentists to manage. The present study examined the characteristics of this disease, the existing therapeutic options and the relevant considerations for dental professionals.

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“…Subject and methods. Salivary levels of MMP-8 and OPG were studied in 76 children divided into four equal groups: group 1, children with stage 1-2 CKD receiving a drug treatment; group 2, children with end-stage CKD receiving renal replacement therapy with hemodialysis; group 3, children one year after the kidney transplantation; and group 4 (comparison group), children введение Хроническая болезнь почек (ХБП) у детей сопровождается развитием системного нарушения минерального и костного метаболизма и изменениями зубочелюстной системы (ЗЧС) [1,2]. Исходом нарушенного минерального обмена у пациентов с ХБП является почечная остеодистрофия, которая служит причиной развития осложнений и неблагоприятных исходов у пациентов с терминальной стадией ХБП [3,4].…”

Section: Changes In Mineral Homeostasis Cause Bone Disorders Of the Dentition In Children With Chronic Kidney Disease (Ckd) And May Develunclassified

Matrix metalloproteinase-8 and osteoprotegerin in saliva of children with chronic kidney disease

Морозова¹,

Захарова²,

Лакомова³

et al. 2021

Nauchno-Prakticheskii Zhurnal «Patogenez»

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Изменения минерального гомеостаза являются причиной костных нарушений зубочелюстной системы (ЗЧС) при хронической болезни почек (ХБП) у детей и могут развиваться задолго до появления клинических проявлений уремической токсинемии на 2-й стадии ХБП. В последние годы большое внимание уделяется неинвазивным методам диагностики патологии полости рта у детей. Наиболее известными индикаторами нарушения костного метаболизма считают матриксную металлопротеиназу 8 (ММР-8) и остеопротогерин (OPG). Цель исследования - установить закономерности изменения содержания ММР-8 и OPG в слюне детей с различной тяжестью ХБП. Объект и методы. Проведено исследование содержания ММР-8 и OPG в слюне у 76 детей, которые были разделены на равные группы по 19 человек: 1 группа - дети с ХБП 1-2 степени, получающие медикаментозное лечение; 2 группа - дети с терминальной стадией ХБП, получающие заместительную почечную терапию в объёме гемодиализа; 3 группа - дети через год после перенесённой трансплантации почки; 4 группа (группа сравнения) - дети с малой хирургической патологией, не имеющие патологии почек. Сбор слюны осуществлялся абсорбционным методом до медикаментозной коррекции основного заболевания утром до приема пищи. Исследование ММР-8 и OPG проводили методом твердофазного иммуноферментного анализа. Результаты. Установлено, что содержание ММР-8 и OPG в слюне у детей с различной степенью ХБП было значительно выше по отношению к группе сравнения. Максимальные значения ММР-8 регистрировались во 2-й группе у детей с терминальной ХБП, находящихся на гемодиализе. Повышение содержания OPG в слюне отмечалось в 1 группе детей с ХБП 1-2-й степени и 3-й группе пациентов, через год после перенесённой трансплантации почки. Заключение. Полученные результаты показывают возможность использования слюны в качестве биологической жидкости для диагностики доклинических этапов нарушения костного метаболизма у детей с ХБП, а ММР-8 и OPG в слюне могут рассматриваться в качестве предиктивных и прогностических маркеров. Changes in mineral homeostasis cause bone disorders of the dentition in children with chronic kidney disease (CKD) and may develop long before the onset of clinical manifestations of uremic toxemia in stage 2 CKD. In recent years, much attention has been paid to noninvasive methods for diagnosing oral pathology in children. The most common indicators of metabolic bone disorders are matrix metalloproteinase-8 (MMP-8) and osteoprotogerin (OPG). The aim of the study was to establish the patterns of changes in salivary concentrations of MMP-8 and OPG in children with various severity of CKD. Subject and methods. Salivary levels of MMP-8 and OPG were studied in 76 children divided into four equal groups: group 1, children with stage 1-2 CKD receiving a drug treatment; group 2, children with end-stage CKD receiving renal replacement therapy with hemodialysis; group 3, children one year after the kidney transplantation; and group 4 (comparison group), children with a minor surgical pathology without a kidney pathology. Saliva samples were collected by the absorption method before administration of drugs for the underlying disease, one hour before the morning meal. Salivary concentrations of MMP-8 and OPG were measured by enzyme-linked immunosorbent assay. Results. Salivary levels of MMP-8 and OPG were significantly higher in children with various severity of CKD than in the comparison group. The highest values of MMP-8 were observed in group 2 children with end-stage CKD on hemodialysis. Increased salivary OPG was noted in group 1 children with stage 1-2 CKD and in group 3 patients one year after the kidney transplantation. Conclusion. Saliva can be used as a biological fluid for diagnosis of preclinical stages of bone metabolism disorders in children with CKD, and salivary MMP-8 and OPG can be considered as predictive and prognostic markers.

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Chronic kidney disease–mineral bone disorder: an update on the pathology and cranial manifestations

Cited by 12 publications

References 20 publications

Dental Care for Patients with End-Stage Renal Disease and Undergoing Hemodialysis

Dental Care for Patients with End-Stage Renal Disease and Undergoing Hemodialysis

Oral manifestations in chronic uremia patients

Matrix metalloproteinase-8 and osteoprotegerin in saliva of children with chronic kidney disease

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